Endometrial polyps are a common cause of dysfunctional uterine bleeding and typically occur in post-menopausal pre-pubertal pre-menopausal( post-menopausal, pre-pubertal, pre-menopausal ) women.
The peak incidence of endometrial carcinoma is 50-60 years 30-40 years 70-80 years( 50-60 years, 30-40 years, 70-80 years ). It is uncommon for endometrial carcinoma to present in those under 40 over 65( under 40, over 65 )
Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is a hereditary malignant syndrome which leaves the individual highly susceptible to other forms of cancer. HNPCC is also known as Syndrome
Lynch Syndrome, as well as predisposing the individual to colorectal cancer (HNPCC), also leaves the individual at high risk of which three of the following cancers?
Endometrial cancer
Breast cancer
Ovarian cancer
Vulval cancer
Lung cancer
Oesophageal cancer
Which two of the following are Type I Endometrial Carcinomas?
Endometrioid
Serous
Clear Cell
Mucinous
Which two of the following are Type II Endometrial Carcinomas?
❌ Endometrial Carcinomas are associated with unopposed Oestrogen and atypical hyperplasia ❌ Endometrial Carcinomas are associated with TP53 mutation
A serous endometrial carcinoma is associated with unopposed oestrogen
Atypical hyperplasia is a precursor to clear cell endometrial carcinoma
The precursor to endometrioid carcinoma is atypical hyperplasia.
Mucinous Endometrial Carcinomas are associated with TP53 mutation
Mucinous Endometrial Carcinomas are associated with unopposed oestrogen.
Which of the following are associated with Microsatellite Instability?
Endometrioid Endometrial Carcinoma
Mucinous Endometrial Carcinoma
Serous Endometrial Carcinoma
Clear Cell Endometrial Carcinoma
Which condition is defined as the following?
"Germline mutation of DNA mismatch repair genes"
Obesity is a highly substantial risk factor for endometrial carcinoma
Obesity is a risk factor for endometrial carcinoma as fat cells called adipocytes express an enzyme called which converts ovarian androgens into oestrogens, thus promoting endometrial proliferation.
Lynch Syndrome has an autosomal inheritance pattern
One of the characteristic traits of Lynch Syndrome is a lack of Microsatellite Instability
Type II Endometrial Carcinomas (Serous and Clear Cell) are more aggressive than Type I cancers as they spread along the fallopian tube mucosa allowing extrauterine presentation.
Which of the following Type II Endometrial Carcinomas is known to spread to the peritoneum early in the disease process?
Endometrioid carcinoma has good prognosis as it is usually confined to the uterus at presentation
Uterine Leiomyomas are also called Uterine
