Uterine Cancer

Matthew Coulson
Quiz by Matthew Coulson, updated more than 1 year ago
Matthew Coulson
Created by Matthew Coulson over 2 years ago
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2

Description

Endometrial carcinomas

Resource summary

Question 1

Question
Endometrial polyps are a common cause of dysfunctional uterine bleeding and typically occur in [blank_start]post-menopausal[blank_end] women.
Answer
  • post-menopausal
  • pre-pubertal
  • pre-menopausal

Question 2

Question
The peak incidence of endometrial carcinoma is [blank_start]50-60 years[blank_end]. It is uncommon for endometrial carcinoma to present in those [blank_start]under 40[blank_end]
Answer
  • under 40
  • over 65
  • 50-60 years
  • 30-40 years
  • 70-80 years

Question 3

Question
Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is a hereditary malignant syndrome which leaves the individual highly susceptible to other forms of cancer. HNPCC is also known as [blank_start]Lynch[blank_end] Syndrome
Answer
  • Lynch

Question 4

Question
Lynch Syndrome, as well as predisposing the individual to colorectal cancer (HNPCC), also leaves the individual at high risk of which three of the following cancers?
Answer
  • Endometrial cancer
  • Breast cancer
  • Ovarian cancer
  • Vulval cancer
  • Lung cancer
  • Oesophageal cancer

Question 5

Question
Which two of the following are Type I Endometrial Carcinomas?
Answer
  • Endometrioid
  • Serous
  • Clear Cell
  • Mucinous

Question 6

Question
Which two of the following are Type II Endometrial Carcinomas?
Answer
  • Endometrioid
  • Mucinous
  • Serous
  • Clear Cell

Question 7

Question
[blank_start]Type I[blank_end] Endometrial Carcinomas are associated with unopposed Oestrogen and atypical hyperplasia [blank_start]Type II[blank_end] Endometrial Carcinomas are associated with TP53 mutation
Answer
  • Type II
  • Type I

Question 8

Question
A serous endometrial carcinoma is associated with unopposed oestrogen
Answer
  • True
  • False

Question 9

Question
Atypical hyperplasia is a precursor to clear cell endometrial carcinoma
Answer
  • True
  • False

Question 10

Question
The precursor to endometrioid carcinoma is atypical hyperplasia.
Answer
  • True
  • False

Question 11

Question
Mucinous Endometrial Carcinomas are associated with TP53 mutation
Answer
  • True
  • False

Question 12

Question
Mucinous Endometrial Carcinomas are associated with unopposed oestrogen.
Answer
  • True
  • False

Question 13

Question
Which of the following are associated with Microsatellite Instability?
Answer
  • Endometrioid Endometrial Carcinoma
  • Mucinous Endometrial Carcinoma
  • Serous Endometrial Carcinoma
  • Clear Cell Endometrial Carcinoma

Question 14

Question
Which condition is defined as the following? "Germline mutation of DNA mismatch repair genes" [blank_start]Lynch Syndrome[blank_end]
Answer
  • Lynch Syndrome

Question 15

Question
Obesity is a highly substantial risk factor for endometrial carcinoma
Answer
  • True
  • False

Question 16

Question
Obesity is a risk factor for endometrial carcinoma as fat cells called adipocytes express an enzyme called [blank_start]aromatase[blank_end] which converts ovarian androgens into oestrogens, thus promoting endometrial proliferation.
Answer
  • aromatase

Question 17

Question
Lynch Syndrome has an autosomal [blank_start]dominant[blank_end] inheritance pattern
Answer
  • dominant

Question 18

Question
One of the characteristic traits of Lynch Syndrome is a lack of Microsatellite Instability
Answer
  • True
  • False

Question 19

Question
Type II Endometrial Carcinomas (Serous and Clear Cell) are more aggressive than Type I cancers as they spread along the fallopian tube mucosa allowing extrauterine presentation.
Answer
  • True
  • False

Question 20

Question
Which of the following Type II Endometrial Carcinomas is known to spread to the peritoneum early in the disease process?
Answer
  • Serous Endometrial Carcinoma
  • Clear Cell Endometrial Carcinoma

Question 21

Question
Endometrioid carcinoma has good prognosis as it is usually confined to the uterus at presentation
Answer
  • True
  • False

Question 22

Question
Uterine Leiomyomas are also called Uterine [blank_start]Fibroids[blank_end]
Answer
  • Fibroids
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