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Quiz

L39 Insulins for optimal therapy

Gelöschter Nutzer 12 Fragen Aktualisiert am 26 Mai 2019

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Fragen in diesem Quiz (12)

  1. 1The goal of all insulin treatment is to mimic the healthy pancreas’ way of secreting insulin to the blood stream.
    1. ARichtig
    2. BFalsch
  2. 2Which of these is not a limitation of regular human insulin?
    1. ASlower onset of activity that requires injections to be given 30 to 45 minutes before meals
    2. BPatient inconvenience
    3. CSafety concerns if the meal is not eaten when scheduled
    4. DDifficult to culture and produce
  3. 3Insulins are first injected as hexamers, but become dimers and monomers which can enter the blood.
    1. ARichtig
    2. BFalsch
  4. 4Insulins are categorized first by length of action.
    1. Rapid-Fast acting Insulin: begins to work approximately [blank_start]15[blank_end] min after injection, peaks in about 1 hour, and continues to work for 2 to 4 hour.
    This is usually taken directly prior to a [blank_start]meal[blank_end] and in addition to a [blank_start]long[blank_end]-acting insulin.
    2. Short-Regular acting Insulin: reaches the bloodstream [blank_start]30[blank_end]min to an hour after injection, peaks anywhere from 2 to 3 hours after Injection, and is effective for approximately 6-8 hours.
    It is usually given before a meal and in addition to a long-acting
    insulin.
    3. Intermediate acting Insulin: generally reaches the bloodstream about [blank_start]2 to 4[blank_end] hours after injection, peaks 4 to 8 hours later and is effective for about 12 to 18 hours.
    It is usually taken [blank_start]twice[blank_end] a day and in addition to a [blank_start]rapid- or short[blank_end] acting insulin.
    4. Long acting Insulin: starts working several hours after injection and works for approximately [blank_start]24[blank_end] hours.
    If necessary, it is often used in combination with rapid- or short acting insulin.
    1. A15
    2. Bmeal
    3. Clong
    4. D30
    5. E2 to 4
    6. Ftwice
    7. Grapid- or short
    8. H24
  5. 5Choose the incorrect statement.
    1. ABeing in a hot environment or having a temperature will increase the speed of insulin absorption.
    2. BAn abdominal injection will be absorbed slower than a thigh injection if both are subcut.
    3. CThe absorption from the buttocks is slower that the abdomen, but faster than the thigh, if all are subcut.
    4. DMassage of the injection site will increase the speed of insulin absorption.
    5. EA thicker layer of subcutaneous fat gives a slower absorption of insulin.
  6. 6Rapid insulins are lispro, aspart, and glulisine.
    • Lispro - a human analogue which works [blank_start]more[blank_end] quickly than soluble human insulin because the insulin molecule has been changed slightly. Through [blank_start]recombinant[blank_end] DNA technology, the final lysine and proline residues on the C-terminal end of the [blank_start]B[blank_end]-chain are reversed. This modification does not alter receptor binding, but blocks the re-formation of insulin [blank_start]dimer and hexamers[blank_end]. It is sold under the brand name [blank_start]Humalog[blank_end].
    • Aspart - a human analogue which also works [blank_start]faster[blank_end] than soluble human insulin because of a substitution which reduces the tendency of the
    insulin to form [blank_start]hexamers[blank_end]. Sold under the brand name [blank_start]Novolog[blank_end].
    1. Amore
    2. Brecombinant
    3. CB
    4. Ddimer and hexamers
    5. EHumalog
    6. Ffaster
    7. Ghexamers
    8. HNovolog
  7. 7Which of these is not a short acting regular human insulin brand?
    1. AActrapid
    2. BHumulin R
    3. CActshort
  8. 8Humulin N and Novolin N are the most common brands of NPH insulin, which is intermediate acting.
    1. ARichtig
    2. BFalsch
  9. 9The delayed release of insulin from protamine complexes causes NPH insulin to last longer than soluble human insulin.
    1. ARichtig
    2. BFalsch
  10. 10Insulin glargine, marketed under the brand name [blank_start]Lantus[blank_end], is a human insulin analogue. After injection, micro-[blank_start]crystals[blank_end] slowly release insulin for about 24
    hours. It uses pH reactions to form micro-precipitates under the skin,
    which create the time-release action.
    Insulin glargine differs from human insulin by replacing asparagine with
    [blank_start]glycine[blank_end] in position 21 of the [blank_start]A[blank_end]-chain, and by carboxy-terminal extension of
    [blank_start]B[blank_end]-chain by 2 [blank_start]arginine[blank_end] residues. The arginine amino acids shift the isoelectric point from a pH of 5.4 to 6.7, making the molecule more soluble at an [blank_start]acidic[blank_end] pH and less soluble at [blank_start]physiological[blank_end] pH.
    This allows for the subcutaneous injection of a [blank_start]clear[blank_end] solution with [blank_start]peakless[blank_end] dissolution and absorption for at least 24 hours.
    1. ALantus
    2. Bcrystals
    3. Cglycine
    4. DA
    5. EB
    6. Farginine
    7. Gacidic
    8. Hphysiological
    9. Iclear
    10. Jpeakless

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Der Nutzer hat seine Fachbereichs-Information gelöscht. Quiz am L39 Insulins for optimal therapy, erstellt von Gelöschter Nutzer am 26/05/2019.
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Gelöschter Nutzer
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English
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Erstellt am 26 Mai 2019 · aktualisiert am 26 Mai 2019
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