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L12 Menopause and hormone replacement therapy

Gelöschter Nutzer 11 Fragen Aktualisiert am 2 Okt 2019

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  1. 1Perimenopause
    • Transition period – hormonal and biological changes begin to occur.
    • [blank_start]2 to 8[blank_end] years prior to menopause, [blank_start]irregular[blank_end] menstrual cycles and decrease in cycle [blank_start]length[blank_end].
    • Physical [blank_start]symptoms[blank_end] begin during this period.

    Menopause
    • Permanent cessation of menses (periods) following loss of [blank_start]ovarian follicular[blank_end] function.
    (•Lower ovarian follicular function, [blank_start]less[blank_end] oestrogen and progesterone produced = FSH and LH concentrations [blank_start]increase[blank_end])
    • Diagnosis – amenorrhea for [blank_start]12[blank_end] consecutive months.
    • Occurs typically between ages of 40 and 58 years, median age = [blank_start]52[blank_end] years
    1. A2 to 8
    2. Birregular
    3. Clength
    4. Dsymptoms
    5. Eovarian follicular
    6. Fless
    7. Gincrease
    8. H12
    9. I52
  2. 2Select ALL the COMMON symptoms of menopause.
    1. ADyspareunia (difficult or painful sexual intercourse)
    2. BVaginal dryness
    3. CVulvovaginal atrophy
    4. DNight sweats
    5. EHot flushes
    6. FMood swings
    7. GDepression
    8. HUrinary frequency
    9. IDecreased libido
  3. 3Vasomotor symptoms such as hot flushes and night sweats are possibly due to reduced hormones increasing the hypothalamus’ [blank_start]sensitivity[blank_end] to changes in a body temperature.([blank_start]Small[blank_end] increase in body temperature can result in a hot flush.) Common (≈[blank_start]70[blank_end]%), but not all women get these, and they vary in [blank_start]severity[blank_end]. Overtime, hot flushes diminish and then disappear completely. Median duration [blank_start]5.2[blank_end] years.
    1. Asensitivity
    2. BSmall
    3. C70
    4. Dseverity
    5. E5.2
  4. 4Lowest dose for the shortest duration is the general guideline for HRT.
    1. ARichtig
    2. BFalsch
  5. 5Which of these conditions would not have increased risk for the patient on HRT?
    1. ABreast cancer
    2. BEndometrial cancer
    3. COvarian cancer
    4. DVTE
    5. EStroke
    6. FCHD
    7. GColon cancer
  6. 6Addition of progesterone to estrogen HRT is needed if woman has a uterus, to prevent endometrial hyperplasia and increased cancer risk.
    1. ARichtig
    2. BFalsch
  7. 7Drug treatments:
    1. Different forms of oestrogen: Oestradiol can be given [blank_start]orally[blank_end] as micronized oestradiol, oestradiol valerate, estrone, estriol or conjugated equine oestrogen.
    • [blank_start]Topical[blank_end] vaginal administration is used for localised symptoms
    2. Progesterone: (combined with oestrogen)
    • Levonorgestrel- releasing intrauterine system ([blank_start]Mirena[blank_end])
    3. [blank_start]Bazedoxifene[blank_end] – selective oestrogen receptor modulator (SERM) can be used if progesterone is unsuitable.
    4. [blank_start]Tibolone[blank_end] – synthetic steroid - has weak oestrogen, androgen and progesterone actions – can be used as HRT.
    1. Aorally
    2. BTopical
    3. CMirena
    4. DBazedoxifene
    5. ETibolone
  8. 8Premature menopause is:
    1. AMenopause under 45 years of age
    2. BMenopause under 40 years of age
  9. 9Premature menopausal women:
    • Have [blank_start]earlier[blank_end] onset CVD episodes and osteoporosis.
    • Have [blank_start]reduced[blank_end] breast cancer risk cf. menstruating peers.
    • Are strongly advised to consider HRT until age of [blank_start]50[blank_end]
    1. Aearlier
    2. Breduced
    3. C50
  10. 10Adverse effects of HRT
    • Irregular [blank_start]bleeding[blank_end] with combined regimens
    • Nausea and breast [blank_start]tenderness[blank_end]
    • These adverse effects [blank_start]usually[blank_end] decrease over time, if not lowering dose of HRT may be needed.
    1. Ableeding
    2. Btenderness
    3. Cusually

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Beschreibung
Der Nutzer hat seine Fachbereichs-Information gelöscht. Quiz am L12 Menopause and hormone replacement therapy, erstellt von Gelöschter Nutzer am 02/10/2019.
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Gelöschter Nutzer
Sprache
English
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112
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Erstellt am 2 Okt 2019 · aktualisiert am 2 Okt 2019
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