Karteikarten
Inflammation Flash cards
Karten in diesem Stapel (32)
- 1What are the main cells involved in acute inflammation?polymorph neutrophils, PMNs, and mast cells
- 2What are the main cells involved with chronic inflammation?lymphocytes and plasma cells
- 3What are the cardinal signs of local, acute inflammation?swelling
redness
warmth
pain - 4Immediate vascular response is mediated by mast cells releasing ____?histamine
- 5What mediator is responsible for permeability of post-capillary venules?histamine
- 6This extravascular fluid is characterized by the following: hypocellular protein poor low specific gravity due to increased hydrostatic pressure, lymphatic obstruction, or decreased oncotic pressuretransudate
- 7This extravascular fluid is characterized by the following: cellular protein rice high specific gravity due to increased permeability and inflammationexudate
- 8What are the 6 steps upon neutrophil arrival?1. margination
2. rolling
3. adhesion
4. transmigration
5. chemotaxis
6. phagocytosis - 9Diapedesis is mediated by what?PECAM-1
- 10What are 3 endogenous chemotactic factors?leukotriene B4, complement 5a, interleukin-8, Bacterial products
- 11Name two opsoninsC3b, IgG
- 12This disorder is due to impaired phagolysosome fusion due to a microtubular defectchediak higashi syndrome
- 13Rolling on endothelial cells is mediated by what?E-selectin and P-selectin "speed bumps"
- 14Tight binding by endothelial cells are mediated by________?ICAM-1
VCAM-1 - 15ight binding by leukocytes is mediated by __________?LFA-1 (integrin)
- 16ICAM-1 and VCAM-1 (involved with tight binding in endothelial cells) are upregulated by _________?TNF and IL-1
- 17Integrin (involved with tight binding in leukocytes) is upregulated by______?C5a and LTB
- 18What 2 mechanisms do leukocytes use to phagocytose microorganisms and tissue debris?-reactive oxygen species
-reactive nitrogen species - 19A deficiency in ____ yields in ability to produce hypochlorous acid and puts one at greater risk for candida infectionsMPO (myeloperoxidase)
- 20Poor oxygen dependent killing results in what disease?chronic granulomatous disease
- 21Shut down of inflammatory process occurs by what 2 mediators?IL-10 and TGF-B(By M2 Macrophages
- 22This plasma derived mediator is especially important for pain sensation and vasodilationbradykinin
- 23These 3 proteins indicate an acute phase reaction and are produced by______C reactive protein
fibrinogen
serum amyloid A (SAA)
Liver - 24Increased _________serum acute phase reactant protein can be used to assess risk of myocardial inflammation and atherosclerotic coronary artery disease.CRP
- 25What are 4 distinctive appearances of inflammation that are determined by the type of tissue and agent involved?serous
fibrinous
suppurative
pseudomembranous - 26This appearance of inflammation is marked by abundance fibrinogen which polymerizes into a thick fibrin coatingfibrinous inflammation
- 27What protein on the leukocyte helps with rolling?sialylated lewis X glycoproteins
- 28If injury persists, how does acute inflammation go on to chronic inflammation?macrophages present antigen to activate CD4 helper T cells, which secrete cytokines that promote chronic inflammation
- 29What are the 4 plasma mediator systems triggered by activation of factor XII (Hageman factor)-kinin cascade
-clotting (coagulation) cascade
-fibrinolytic system
-complement cascade - 30types of scarringhypertrophic
keloid
exuberant/excessive granulation
formation of contractures - 31Differentiate keloid from hypertrophied scar?
- 32Enumerate functions of macrophage in inflammation
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- Der Nutzer hat seine Fachbereichs-Information gelöscht. Karteikarten am Inflammation Flash cards, erstellt von Gelöschter Nutzer am 24/02/2020.
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