Prediction of Solubility

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Need to know structure and properties of solute and solvent

Speculation of a good solvent based on the "like dissolves like" principle:

-Polar solutes dissolve in polar solvents

-Non-polar solutes dissolve in non-polar solvents

Polarity depends on polar groups attached, polar molecules have a higher dipole moment

Physiochemical Prediction of Solubility

Attractive forces between polar molecules are much stronger than those between non-polar molecules

Polar solute forces of attraction are too great to facilitate separation by the insertion of a non-polar molecule as solute-solvent forces will be relatively weak