Quiz
DF16 Drug Partioning
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Fragen in diesem Quiz (4)
1Partioning is the distribution of solutes between [blank_start]immiscible[blank_end] solvents — S(water) ⇄ S(oil).
The solute distributes in a [blank_start]definite concentration ratio[blank_end] known as the [blank_start]partition coefficient[blank_end]. (K or P)
K = [blank_start][oil]eq[blank_end] / [blank_start][water]eq[blank_end]- Aimmiscible
- Bdefinite concentration ratio
- Cpartition coefficient
- D[oil]eq
- E[water]eq
2The partition coefficient indicates the relative lipophilic/hydrophilic character of a compound. Low K indicates a [blank_start]hydrophilic[blank_end] compound, high K indicates a [blank_start]lipophilic[blank_end] compound.
- Ahydrophilic
- Blipophilic
3True partition coefficient (K): the coefficient when all drug is in the [blank_start]unionised[blank_end] form (pH independent!)
Apparent partition coefficient (K’): the coefficient that applies when some of the drug in the [blank_start]aqueous[blank_end] phase is [blank_start]ionised[blank_end] as a result of the pH- Aunionised
- Baqueous
- Cionised
4Preservatives as an example:
Preservatives prevent growth of microorganisms in the [blank_start]aqueous[blank_end] phase, and are often weak electrolytes. The problem is that preservatives [blank_start]partition[blank_end] between the aqueous and the oil phase. We therefore want to keep it in the [blank_start]unionised[blank_end] form so it is active.- Aaqueous
- Bpartition
- Cunionised
Informationen
- Beschreibung
- PHCY211 (Formulation) Quiz am DF16 Drug Partioning, erstellt von Mer Scott am 30/04/2018.
- Autor
- Mer Scott
- Sprache
- English
- Aufrufe
- 6
- Schlagwörter
- Bewertung
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