Quiz
PK Exam 1 Review (Karla)
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Fragen in diesem Quiz (12)
1Which of the following are factors affecting GI absorption?
- AVarying regional pH of GI and the pKa of the drug
- BGastric Emptying
- CFood
- DIntestinal motility or small intestine transit time (SIT)
- EAll of the above
2During absorption, the longer the concentration of the drug is maintained the smaller the volume of distribution of the drug
- ARichtig
- BFalsch
3Which of the following is NOT a physiologic or physical factor that governs the movement of drug through the membrane
- APerfusion
- BNature of the membrane
- CFirst-pass metabolism
- DSize fo the drug molecule
- EpH
4Low pH of stomach increases the concentration of unionized weakly acidic drugs and high pH of intestine forms un-ionized weakly basic drugs.”
- ARichtig
- BFalsch
5For acidic drugs:
Unionized/ionized= 10^ ([blank_start]pKa[blank_end]-[blank_start]pH[blank_end])- ApKa
- BpH
- CpH
- DpKa
6For basic drugs:
Unionized/Ionized= 10^ ([blank_start]pH[blank_end]-[blank_start]pKa[blank_end])- ApH
- BpKa
- CpKa
- DpH
7What effect does food have on gastric emptying?
- AFood does not have an effect on gastric emptying
- BFood slows down gastric emptying
- CFood speeds up gastric emptying
- DFood rich in carbohydrates empty slower than foods rich in fat
8It is recommended to take drugs with food if rapid onset of action is desired.
- ARichtig
- BFalsch
9It is not advisable to administer proteins and polypeptide drugs orally because of the presence of proteolytic enzymes in the GI tract lead to toxicity.
- ARichtig
- BFalsch
10If the concentration of a drug is much greater than the km value, the volume of distribution equals Vmax.
- ARichtig
- BFalsch
11What produces plasma proteins?
- AMast cells
- BHaemoglobin
- CRenal enzymes
- DHepatocytes
- ENone of the above
12Which statement(s) is/are true based on the rate of metabolism equation below:
V= Vmax Cd/Km + Cd- AWhen conc. of the drug (Cd) is much smaller than Km, rate of metabolism follows first-order kinetics.
- BWhen Cd is much higher than Km, rate follows zero-order kinetics.
- CWhen Cd is much higher than Km V= Vmax
- DWhen conc. of the drug (Cd) is much smaller than Km, rate of metabolism follows zero-order kinetics.
- EWhen Cd is much higher than Km, rate follows first-order kinetics.
Informationen
- Beschreibung
- Lecture 1-3
- Autor
- Stephanie Reid
- Sprache
- English
- Aufrufe
- 1
- Verlauf
- Erstellt am 7 Feb 2020 · aktualisiert am 7 Feb 2020
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