11493573
Beschreibung
Quiz von Michael Jardine, aktualisiert more than 1 year ago
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Erstellt von Michael Jardine
vor mehr als 6 Jahre
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Frage 1
Frage
Atheroma starts as fatty and cellular infiltration of the endothelium. Later becomes larger, [blank_start]__________[blank_end] and [blank_start]__________[blank_end] and may block 80% of the XS of parts of the coronary arteries. (put them in alphabetic order)
Antworten
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Calcified
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Fibrosed
Frage 2
Frage
What’s responsible for the drastically reduced force output in EARLY ischaemic failure?
Antworten
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Changes in pH
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Changes in Pi
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Failure of excitation-contaction coupling
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Low ATP
Frage 3
Frage
True or false: ROS = Reactive Oxygen Species.
Antworten
- True
- False
Frage 4
Frage
Why does early reperfusion cause complete recovery whereas late reperfusion does not?
Antworten
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On reperfusion damage mitochondria produce Reactive Oxygen Species (ROS) from O2, which damage membrane and contractile proteins
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Coupled exchanger theory causes Ca2+ overload which activates Ca2+-activated proteases and causes cell damage
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Both of the above
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[none of the above]
Frage 5
Frage
True or false: ROS can cause damage through protein modification whereby –SH groups are oxidised into –S-S- groups.
Antworten
- True
- False
Frage 6
Frage
True or false: ROS can cause damage through protein modification whereby –S-S- groups are oxidised into –SH groups.
Antworten
- True
- False
Frage 7
Frage
Excess ROS leads to specific mitochondrial damage in which the MPTP opens. MPTP = ??
Antworten
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Mitochondrial Permeability Transition Pore
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Modification of Protein Transition Pore
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Mitochondrial Pore Transition Permeability
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Mitochondrial Pore Transition Protein
Frage 8
Frage
When the MPTP opens, Oxidative phosphorylation [blank_start]__________[blank_end], mitochondrial contents leak out, and the cell will eventually die by necrosis.
Antworten
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Stops
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Starts
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Increases
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Decreases
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