Malignancies

Mark George
Quiz by Mark George, updated more than 1 year ago
Mark George
Created by Mark George over 5 years ago
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Description

Pathophysiology and pharmacology of malignancies lecture

Resource summary

Question 1

Question
Which of the following are features of cancer cells?
Answer
  • autonomic & immortal
  • static & aplastic
  • transformational & variable
  • anaplastic & lacking apoptosis

Question 2

Question
Which of the following can act as tumor markers?
Answer
  • proteins
  • vitamins
  • hormones
  • antibodies
  • antigens

Question 3

Question
Tumor markers can confirm diagnosis of some cancers.
Answer
  • True
  • False

Question 4

Question
Which of the statements below is FALSE?
Answer
  • Pheochromocytoma is a tumor of the adrenal medulla.
  • Adrenaline can act as a tumor marker.
  • PSA is a tumor marker specifically for prostate cancer
  • Tumor markers can be found in blood, urine and CSF.

Question 5

Question
Gene mutations can result in...... (Select the INCORRECT answer)
Answer
  • Repeated division of telomeres.
  • Activation of tumor suppression genes.
  • Cancer cells stimulating angiogenesis
  • Stimulation of growth promotion pathways
  • Transformation of proto-oncogenes into oncogenes.

Question 6

Question
Regarding the contribution of obesity to cancer, which of the following statements are true?
Answer
  • BMI greater than 30 linked to cancer.
  • The endocrine and metabolic activity of adipose tissue is thought to contribute to cancer development
  • The increased release of FFA and TNF is thought to contribute to cancer development
  • Increased levels of insulin is also linked to cancer development.

Question 7

Question
Which of the following sets of factors all increase the risk of cancer development?
Answer
  • CHronic inflammation, over-exertion, poor diet and television.
  • Viruses, bacteria, chronic inflammation and environmental factors
  • smoking, radiation, alcohol and shopping
  • Ulcerative colitis, chronic asthma, physical inactivity and Epstein Barr Virus

Question 8

Question
Select the true statements regarding pharmacological management of cancer.
Answer
  • Narcotic analgesics act to inhibit the release of substance P
  • Adverse effects of narcotic analgesics include diarrhoea, psychological disturbances and vomiting
  • Fentanyl is slow to act but has a long half life.
  • Accumulation of morphine can result in coma
  • Buprenorphine and azathioprine are used in the treatment of terminal cancer pain

Question 9

Question
Select the cytotoxic agents
Answer
  • Calcium channel blockers
  • Antiarbitrucins
  • Antimetabolites
  • Alkylating agents
  • Hormonal agonists
  • Hormonal inhibitors

Question 10

Question
Chlorambucil and Carboplatin target the mechanism for cell division
Answer
  • True
  • False

Question 11

Question
The antiandrogenic drug Flutamide is administered to prostate cancer sufferers.
Answer
  • True
  • False

Question 12

Question
5-fluorouacil (5-FU) is an hormonal inhibitor that acts by blocking synthesis of pyramidine nucleotides
Answer
  • True
  • False

Question 13

Question
Side effects common to alkylating agents, antibiotic-type agents and antimetabolites include
Answer
  • Bone marrow suppression
  • GI disturbances
  • mouth ulcers
  • impaired fertility
  • bleeding
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