1308146
Beschreibung
Quiz von Peter Seymour, aktualisiert more than 1 year ago
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Erstellt von Peter Seymour
vor mehr als 9 Jahre
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Frage 1
Frage
A rapidly dividing cell will have a greater abundance of which nucleotide?
Antworten
-
Guanine and Adenine because purine synthesis is more important for a developing cell
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Cytosine and Thiamine because pyrimidine synthesis is less taxing and therefore proceed more quickly
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The concentration of pyrimidines and purines will be equal regardless of the conditions
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Purines are critical for DNA replication, so purine concentration will be higher
Frage 2
Frage
Which of the following is a nucleotide?
Antworten
-
Image:138px-Adenin.svg (image/png)
Frage 3
Frage
For the previous question why was the correct answer the only nucleotide?
Antworten
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It was the only answer that consisted of a nucleoside bound to a phosphate group
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All of the other answers were sugars
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All of the other answers were bases
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None of the other answers were biologically important molecules
Frage 4
Frage
Which of the following is not a biological function of Nucleotides?
Antworten
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They are precursors to glycogen and other phosphoglycerides
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Nucleotides exclusively compromise the universal energy currency
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They serve as metabolic regulators and mediate the action of many hormones
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Nucleotides entirely make up three major co-enzymes: NADH, FAD, and CoA
Frage 5
Frage
cAMP is a nucleotide that mediates hormones
Antworten
- True
- False
Frage 6
Frage
Purine biosynthesis involves which of the following precursors?
Antworten
-
Glycine
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Glutamine
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Aspartate
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carbon dioxide
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Formyltetrahydrofolate
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All of the above are required atom contributors
Frage 7
Frage
PRPP (Phosphoribosylpyrophosphate) is the source of the ribose sugar in...
Antworten
-
purine de novo synthesis and purine salvage pathways
-
purine de novo synthesis
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purine salvage
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purine and pyrimidine de novo synthesis
Frage 8
Frage
Which describes the committed step for purine de novo synthesis?
Antworten
-
Glutamine-PRPP amido-transferase is the active enzyme
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PRPP feeds into the committed step
-
Glutamine feeds into the step and becomes glutamate
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All of the above
Frage 9
Frage
THF is an enzyme that performs which of the following actions?
Antworten
-
Eliminates an amide group
-
Transfers one carbon from N10-Formyl THF to the growing purine precursor
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Allosterically activates HGRPT
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Facilitates a Glutamine dependent nitrogen tranfer
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Facilitates ring closure of the growing purine
Frage 10
Frage
The base hypoxanthine is described by which of the following statements?
Antworten
-
Inosinic Acid (IMP) is the nucleoside form of hypoxanthine
-
Hypoxanthine is critical only to the conversion of IMP to GMP not IMP to AMP
-
Hypoxanthine is reduced to xanthine during the purine synthesis pathway
-
The oxidation of hypoxanthine to xanthine is blocked by allpurinol
Frage 11
Frage
PRPP impacts which of the following?
Antworten
-
De novo synthesis of purines
-
Direct production of IMP through PRPP's reaction with Hypoxanthine
-
Direct production of GMP through PRPP's reaction with Guanine
-
All of the above are catalyzed by HGPRT and all are true in healthy cells
Frage 12
Frage
Which of the following is deficient in Gout?
Antworten
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HGPRT
-
ADA (adenosine deaminase)
-
PNP (purine nucleoside phosphorylase)
-
You have to be more specific, gout could be the result of numerous enzyme deficiencies
-
XO (xanthine oxidase)
Frage 13
Frage
Lesch Nyhan Syndrome is caused by a deficiency in which of the following?
Antworten
-
PRPP
-
XO (xanthine oxidase)
-
ADA (adenosine deaminase)
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HGPRT
-
You have to provide more information, Lesch Nyhan Syndrome could be caused by the deficiency of a number of different enzymes
Frage 14
Frage
Which is the committed step of Pyrimidine synthesis?
Antworten
-
Aspartate Transcarbamoylase ATCase
-
Dihydroorotase
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OPRT
-
CTP synthetase
Frage 15
Frage
Familial Orotic Aciduria can be treated using which of the following methods?
Antworten
-
There is no curative treatment, simply a management of symptoms
-
Delivery of large doses of orally administered uridine to simply bypass the early steps of pyrimidine synthesis
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Delivery of large doses of the missing/deficient orotate phosphoribosyltransferase (OPRT)
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Delivery of fully synthesized pyrimidines for uptake into the cell
Frage 16
Frage
Which of the following are made by a two enzyme complex (Thymidylate Synthetase and Dihydrofolate reductase) after ribonucleotide reductase acts on freshly minted purines and pyrimidines?
Antworten
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dADP
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dGDP
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dCDP
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dUDP
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dTTP
Frage 17
Frage
dATP is the master negative regulator of Ribonucleotide Reductase.
Antworten
- True
- False
Frage 18
Frage
Which of the following enzymes should I know really well?
Antworten
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Ribosomyl Reductase
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PRPP Synthetase
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Xanthine Oxidase
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Dihydrofolate Reductase
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HGPRT
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Amidophosphoryl Transferase ATase = glutamine PRPP amidotransferase
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I should probably know all of these
Frage 19
Frage
Why do we use "De Novo" instead of saying from scratch?
Antworten
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Because Carl Sagan's famous Apple Pie from scratch comment makes it too awesome to use in any setting other than musing about the universe
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Because De Novo is more descriptive
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To confuse those who are sadly lacking in medical jargon
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Because fancy language is awesome
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