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Quiz

DF13 Tablet manufacturing and defects affecting therapy

Mer Scott 8 Fragen

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Fragen in diesem Quiz (8)

  1. 1Particulate system:
    Step 1: Particulate ingredients are [blank_start]fed into a die[blank_end]
    Step 2: Particulates are [blank_start]compressed between punches[blank_end]
    Step 3: Compacted mass is [blank_start]ejected[blank_end] from the die

    So therefore prerequisites:
    Prerequisite 1: Particles must be [blank_start]free flowing[blank_end]
    Prerequisite 2: Particles must [blank_start]cohere on compression[blank_end]
    Prerequisite 3: Tablet [blank_start]must not adhere[blank_end] to punches of die and must [blank_start]remain coherent[blank_end] after ejection
    1. Afed into a die
    2. Bcompressed between punches
    3. Cejected
    4. Dfree flowing
    5. Ecohere on compression
    6. Fmust not adhere
    7. Gremain coherent
  2. 2Manufacturing processes:
    1. [blank_start]Direct compression[blank_end]
    - Powder particles are directly compressed into tablets
    2. Compression of granules
    - Powder particles are formulated as granules [blank_start]prior[blank_end] to
    the compression into tablets
    2.a) Dry granulation
    - Using [blank_start]pressure[blank_end] (often with binders)
    2.b) Wet granulation
    - Using [blank_start]solvents[blank_end] (often containing binders)
    1. ADirect compression
    2. Bpressure
    3. Csolvents
    4. Dprior
  3. 3Select all correct statements.
    1. AMicrocrystalline cellulose (MCC) (Avicel®) is a common excipient used as a filler and binder in direct compression.
    2. BStarch and pregelatinised starch is a filler, binder, and disintegrant for direct compression.
    3. CSodium dodecyl sulphate is used as a drying agent in granulation.
    4. DAerosil (colloidal silicon dioxide) is a common glidant.
    5. EMixtures of tartaric acid or citric acid and sodium bicarbonate
      or calcium carbonate produce CO in contact with moisture.
  4. 4Granulation is done:
    1. To [blank_start]improve flow[blank_end] properties and [blank_start]reduce weight variation[blank_end] of tablets.
    Powders usually have poor flow property due to large surface area of small particles and their irregular size, shape and surface characteristics.
    2. To improve [blank_start]compression characteristics[blank_end].
    Solute migration occurs during post granulation drying resulting in binder rich granule surface that assists the consolidation of weakly bonding material which are difficult to compact.
    3. To increase [blank_start]bulk density[blank_end] of product.
    1. Aimprove flow
    2. Breduce weight variation
    3. Ccompression characteristics
    4. Dbulk density
  5. 5Put the steps of dry granulation in order.
    [blank_start]Mixing[blank_end] → [blank_start]First compression[blank_end] → [blank_start]Milling and sieving[blank_end] → [blank_start]Mixing (2)[blank_end] → [blank_start]Second compression[blank_end].
    1. AMixing
    2. BFirst compression
    3. CMilling and sieving
    4. DMixing (2)
    5. ESecond compression
  6. 6Put the steps of wet granulation in order.
    [blank_start]Mixing[blank_end] → [blank_start]Wetting[blank_end] → [blank_start]Granulation[blank_end] → [blank_start]Drying[blank_end] → [blank_start]Sieving[blank_end] → [blank_start]Mixing (2)[blank_end] → [blank_start]Compression[blank_end].
    1. AMixing
    2. BWetting
    3. CGranulation
    4. DDrying
    5. ESieving
    6. FMixing (2)
    7. GCompression
  7. 7Granulation liquids for wet granulation:
    If dry binder is [blank_start]mixed[blank_end], the granulating liquid is added alone [blank_start]afterwards[blank_end], or a binder can be added as [blank_start]solution[blank_end].
    Water is commonly used as granulating fluid, because it is [blank_start]cheap and ecological[blank_end]. However it is unsafe for [blank_start]moisture sensitive[blank_end] drugs and prolongs drying time which is deleterious for [blank_start]heat sensitive[blank_end] drugs.
    Organic solvents such as [blank_start]ethanol or isopropanol[blank_end] are also used as granulating fluid because they offer [blank_start]rapid[blank_end] drying and are safe for moisture sensitive drugs. However, it may require [blank_start]flame-proof[blank_end] equipment.
    1. Amixed
    2. Bafterwards
    3. Csolution
    4. Dcheap and ecological
    5. Emoisture sensitive
    6. Fheat sensitive
    7. Gethanol or isopropanol
    8. Hrapid
    9. Iflame-proof
  8. 8Select the additives to granules which are super disintegrates.
    1. ACross-carmellose sodium
    2. BCross povidone
    3. CSodium starch glycolate (4%)
    4. DStarch (10%)
    5. EAginic acid, alginates

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Beschreibung
PHCY211 (Formulation) Quiz am DF13 Tablet manufacturing and defects affecting therapy, erstellt von Mer Scott am 29/04/2018.
Sprache
English
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9
Schlagwörter
phcy211formulation
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