Cellular Adaptations & Necrosis

Beschreibung

Medicine Quiz am Cellular Adaptations & Necrosis, erstellt von Trey W am 18/07/2020.
Trey W
Quiz von Trey W, aktualisiert more than 1 year ago
Trey W
Erstellt von Trey W vor fast 4 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Which of the following is not a pattern of cell death in tissues?
Antworten
  • fibrinoid necrosis
  • fat necrosis
  • coagulative necrosis
  • contracture necrosis

Frage 2

Frage
Compare acute cell injury with cellular adaptations.
Antworten
  • Cellular adaptations develop over a brief period of time and are reversible
  • Acute cell injury can be manifested as reversible cell swelling
  • Acute cell injury can be manifested as irreversible necrosis

Frage 3

Frage
What is lipofuscin?
Antworten
  • Blue-pigmented cytoplasmic inclusions in stressed cells
  • A lipid-containing residual body of autophagy
  • An irreversible "wear and tear" pigment
  • A product of cells undergoing decreased cell turnover

Frage 4

Frage
Metatstatic calcification is due to precipitation of calcium at sites of cell/tissue injury
Antworten
  • True
  • False

Frage 5

Frage
Which of the following mechanisms explains the pathogenesis of alcohol-induced fatty liver?
Antworten
  • Increased delivery of free fatty acids
  • Increased lipogenesis
  • Decreased apoprotein synthesis for triglyceride export
  • Increased utilization of triglycerides and oxidation of fatty acids

Frage 6

Frage
Metaplasia can be characterized by which of the following?
Antworten
  • One adult cell type being replaced by another through chronic injury
  • Irreversible change in cells/tissue
  • Decreased risk of malignancy/neoplasia
  • Increase in cell number

Frage 7

Frage
Which is an example of physiologic apoptosis?
Antworten
  • Formation of the esophageal lumen
  • Syndactyly
  • Muscular dystrophy
  • Chronic lymphocytic leukemia

Frage 8

Frage
Apoptosis can result from endogenous OR exogenous causes
Antworten
  • True
  • False

Frage 9

Frage
In a Masson Trichrome stain
Antworten
  • Nucleic acids stain dark blue
  • Connective tissue stains blue
  • Proteins stain light purple

Frage 10

Frage
Which of the following would you expect to see in necrosis?
Antworten
  • A rounded up, fragmented cell morphology
  • Phagocytosis by neutrophils
  • Phagocytosis by macrophages and nonprofessional macrophages
  • Functionally intact cell membrane

Frage 11

Frage
You are examining the tissue of a patient who had a subarachnoid hemorrhage. When looking at the brain tissue microscopically, what would you expect to observe in the area of hemorrhage?
Antworten
  • Pneumonoultramicroscopicsilicovolcanoconiosis
  • Hemosiderosis
  • Steatosis
  • Anthracosis

Frage 12

Frage
At what point in cell injury would you expect to observe hydropic change of the cell?
Antworten
  • < 10 minutes
  • 10-15 minutes
  • 15-60 minutes
  • 4-8 hours

Frage 13

Frage
You know that irreversible cell injury is often characterized by nuclear changes. Which of the nuclear changes describes pyknosis?
Antworten
  • Fragmentation of the nucleus into dense basophilic fragments ("nuclear debris")
  • Dissolution of nuclear fragments
  • Condensation of chromatin
  • Dilation of the endoplasmic reticulum

Frage 14

Frage
In coagulative necrosis, the shapes of cells and tissues change dramatically, but the nuclei/organelles are intact.
Antworten
  • True
  • False

Frage 15

Frage
Where would you expect to see liquefactive necrosis most often?
Antworten
  • Brain
  • Lungs
  • Abscesses
  • GI tract

Frage 16

Frage
Your patient's cells and tissues demonstrate obvious enzymatic necrosis. You immediately know the condition that (likely) caused this is:
Antworten
  • COVID
  • Acute pancreatitis
  • Myocardial infarction
  • Hypercalcemia

Frage 17

Frage
What is the most common cause of caseous necrosis?
Antworten
  • Dry gangrene
  • Wet gangrene
  • Mycobacteria tuberculosis
  • Eating too much cottage cheese

Frage 18

Frage
Fibrinoid necrosis is caused by injury to vessel walls that causes leakage of protein and fibrin from the circulation that becomes entrapped. Which vascular injury might cause this type of necrosis?
Antworten
  • Immune-complex associated vasculitis
  • Accelerated HTN
  • HTN that has slowly developed over 20 years
  • Excessive scarring

Frage 19

Frage
What is a heterophagosome?
Antworten
  • A secondary lysosome involved in digestion of a cell's own organelles
  • A primary lysosome fused with absorptive vesicles originating from the plasma membrane
  • A small vesicle budding from enzymes on the lateral side of the Golgi apparatus

Frage 20

Frage
In your elective oncology rotation, a patient presents with multiple calcified breast tumors. You know this to be a result of metastatic calcification.
Antworten
  • True
  • False

Frage 21

Frage
Upon histological examination, tissue cells demonstrate what looks like "nuclear dust". This is characteristic of
Antworten
  • karyorrhexis
  • karyolysis
  • karyogram
  • pyknosis

Frage 22

Frage
In response to [blank_start]cigarette smoke[blank_end], columnar epithelial cells of the bronchial epithelium undergo squamous [blank_start]metaplasia[blank_end]. Smoking-induced metaplasia may lead to bronchial squamous cell [blank_start]neoplasia[blank_end].
Antworten
  • cigarette smoke
  • sitting for 12 hours/day
  • drinking too much water
  • pulmonary HTN
  • metaplasia
  • hyperplasia
  • neoplasia
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