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Assessment 1.2 Turning point

Beschreibung

assessment 1.2
Esther Yook
Quiz von Esther Yook, aktualisiert more than 1 year ago
Esther Yook
Erstellt von Esther Yook vor fast 9 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Which of the following statements is not true regarding the need for a dosage form:
Antworten
  • To protect the drug substance from the destructive influences of atmospheric oxygen or humidity
  • To conceal the bitter, salty, or offensive taste or odor of a drug substance.
  • To avoid drug-drug interactions thus providing greater clinical efficacy.
  • To provide for a safe and convenient delivery of accurate dosage

Frage 2

Frage
Which of the following is not true for different crystal polymorphs
Antworten
  • May have different solubility
  • May have different dissolution rate
  • May have different chemical structure
  • May have different melting point
  • May have different physical and chemical stability

Frage 3

Frage
Biopharmaceutics Classification System is used to classify drugs based on
Antworten
  • Melting point and pH
  • Aqueous solubility and bioavailability
  • Aqueous solubility and dissolution rate
  • Intestinal permeability and particle size
  • Dissolution rate and Intestinal permeability
  • Dissolution rate, aqueous solubility and intestinal permeability

Frage 4

Frage
When being incorporated into ointment bases, fine powders such as calamine and zinc oxide are often wetted and smoothed with mineral oil. What name is given to this process
Antworten
  • Attrition
  • Levigation
  • Milling (pulverizing /grinding)
  • Pulverization by intervention
  • trituration

Frage 5

Frage
Which factor does not affect the rate and extent of absorption from immediate release solid dosage froms
Antworten
  • Solubility
  • Dissolution
  • Appearance
  • Permeability
  • Particle size

Frage 6

Frage
Which of the following is NOT a reason for the extemporaneous preparation of a dosage form
Antworten
  • Shortage of a marketed dosage form
  • Need a liquid dosage form for treating a pediatric patient
  • Medication is not commercially available
  • Geriatric patient is able to swallow solid oral dosage form
  • Patient may be allergic to preservative or dyes contained in the drug product

Frage 7

Frage
Which of the following is used in tablet formulations to reduce friction during tablet compression
Antworten
  • Talc powder (Glidant)
  • Lactose (Diluents or Fillers)
  • Gum Acacia (Binders)
  • Magnesium stearate
  • Starch (Disintegrant)
  • Sodium carboxymethyl cellulose (Coatings)

Frage 8

Frage
Before placing a patient onto IV fat emulsions, the pharmacist should confirm that the patient does not have:
Antworten
  • Egg allergies
  • Sensitivities to bisulfate
  • Milk intolerance
  • Lactose intolerance
  • Sensitivities to tartrazine

Frage 9

Frage
Based on the pH partition theory, weakly acidic drugs are most likely to be absorbed from the stomach because:
Antworten
  • The drugs will exist primarily in the unionized, more lipid-soluble form
  • The drugs will exist primarily in the ionized, more water soluble form
  • Weak acids are more soluble in acid media
  • The ionic form of the drug facilitates dissolution
  • Weak acids will further lower the pH

Frage 10

Frage
The passage of drug molecules from a region of high drug concentration to a region of low drug concentration is known as:
Antworten
  • Active transport
  • Bioavailability
  • Biopharmaceutics
  • Simple diffusion
  • Pinocytosis

Frage 11

Frage
A prime consideration in biopharmaceutics is a drug’s “biovavailability” which refers to the relative amount of drug that reaches the :
Antworten
  • small intestine
  • stomach
  • Systemic circulation
  • Liver
  • kidneys

Frage 12

Frage
Which of the following is not true if a physician would like the patient to use a generic product equivalent to the brand-name product
Antworten
  • Both the generic and the brand-name drug products must be pharmaceutical equivalents
  • Both the generic and the brand-name drug products must have the same bioavailability
  • Both the generic and the brand-name drug products must have the same excipients
  • Both the generic and the brand-name drug products must have identical amounts of the API

Frage 13

Frage
Dosage forms of nitroglycerin that are minimally affected by the First-Pass effect include: I. Intravenous II. Transdermal patches III. Sublingual tablets
Antworten
  • I only
  • III only
  • I and II only
  • II and III only
  • I, II and III

Frage 14

Frage
Which of the following is not an advantage of a tablet dosage form:
Antworten
  • Accurate dosage/minimum variability
  • Easiest/cheapest to package and ship
  • Swallowing
  • Patient acceptance
  • Convenience (light and compact)
  • Tamper resistant

Frage 15

Frage
Which of the following IVIVC classes is the intestinal permeability the rate limiting step in systemic drug absorption?
Antworten
  • Class IV
  • Class II
  • Class III
  • Class I

Frage 16

Frage
Which of the following is the primary purpose of orally disintegrating tablet:
Antworten
  • Avoid exposure of content to stomach acid
  • Avoid hepatic first-pass effect
  • Increase drug bioavailability
  • Increase ease of swallowing

Frage 17

Frage
Which of the following organic esters is commonly used in enteric coating of solid dosage forms:
Antworten
  • Phthalate
  • Tannate
  • Succinate
  • Acrylate
  • Phosphate

Frage 18

Frage
Which of the following tablet dosage forms avoids the hepatic first-pass effects?
Antworten
  • Enteric coating
  • Instantly disintegrating
  • Chewable
  • Sublingual
  • Film coated

Frage 19

Frage
The partial or complete separation of the top or bottom crowns of a tablet from the main body of the tablet is known as:
Antworten
  • Lamination
  • Slugging
  • Capping
  • Mottling
  • Picking

Frage 20

Frage
False statement regarding the function of excipients used in tablet manufacture
Antworten
  • Binders promote granulation during the wet granulation process
  • Glidants help promote the flow of the tablet granulation during manufacture
  • Lubricants help patient swallow the tablets
  • Disintegrants are added to tablet formulations to facilitate the disintegration when the tablet contacts water in the gastrointestinal tract.

Frage 21

Frage
Which manufacturing variables would be likely to affect the dissolution of a prednisone tablet in the body?
Antworten
  • The amount and type of binder
  • The amount and type of disintegrant added
  • The force of compression used during tableting
  • All of the above

Frage 22

Frage
If the preparation is compounded from USP/NF ingredients,
Antworten
  • a beyond-use date of 3 months is appropriate
  • a beyond-use date of 6 months is appropriate
  • a beyond-use date of 9 months is appropriate
  • a beyond-use date of 12 months is appropriate

Frage 23

Frage
Inconsistent in-vitro dissolution test results for the same solid oral dosage form of the same drug and strength generally indicate differences in all of the following EXCEPT:
Antworten
  • Dose units containing the same amount of drug but from different manufacturing process by the same manufacturer
  • Dose units from different batches or lots by the same manufacturer
  • Dose units from different manufacturers
  • Dose units from the same batch or lot

Frage 24

Frage
The United States Pharmacopeia (USP) content uniformity test for tablets is used to ensure which quality?
Antworten
  • Bioequivalence
  • Dissolution
  • Potency
  • Purity
  • Toxicity

Frage 25

Frage
Which of the following is most likely to occur with high speed machines that produce ≥ 10,000 tablets per minute?
Antworten
  • Granulation underfilling
  • Excessive tablet hardness
  • Inconsistent tablet weights
  • Capping

Frage 26

Frage
United Stated Pharmacopeia (USP) tests to ensure the quality of drug products in tablet form include all of the following EXCEPT:
Antworten
  • Disintegration
  • Dissolution
  • Hardness and friability
  • Content uniformity
  • Weight variation

Frage 27

Frage
Which of the following is false regarding dusting powders
Antworten
  • Dusted on the skin , no systemic action
  • Must be homogenous, free from potential of causing local irritation
  • Should flow easily, spread uniformly, and cling to the skin upon application
  • Have a systemic action
  • Generally dispensed in sifter-top containers

Frage 28

Frage
Which of the following drug substance property is important for capsule size selection
Antworten
  • Bulk density
  • Particle size
  • Drug substance solubility
  • Melting point

Frage 29

Frage
Which of the following is not part of Capsule Quality Control program
Antworten
  • Drug Content
  • Fill Weight
  • Disintegration
  • Dissolution
  • Hardness
  • Stability
  • Moisture permeation test

Frage 30

Frage
The community pharmacist intends to prepare a fine dusting powder by triturating the components of the formulation in a mortar with a pestle and subsequently passing the mixture through a:
Antworten
  • 80 mesh sieve
  • 60 mesh sieve
  • 20 mesh sieve
  • 8 mesh sieve

Frage 31

Frage
Which of the following can be influenced by Particle Size:
Antworten
  • Dissolution rate
  • Suspendability of suspensions
  • Uniformity of mixtures in powder dosage forms to ensure dose to dose content uniformity
  • Penetrability of particles for inhalation (dry powder inhaler) for deposition deep in the respiratory tract.
  • Nongrittiness of solid particles for ointments, creams, gels
  • All of the above

Frage 32

Frage
When of the following drug substances will soften or liquefy when grinded
Antworten
  • Lactose
  • Starch
  • Camphor
  • Magnesium stearate
  • Sodium carboxy methylcellulose

Frage 33

Frage
Which of the following is NOT an accurate characteristic of the rectum?
Antworten
  • It is approximately 15 – 20 cm in length
  • When void of fecal matter it has a fluid content of 2-3 ml
  • It is non-motile in resting state
  • The mucosal lining contains Goblet cells which release collagen into the lumen

Frage 34

Frage
Of the veins that drain the blood from the rectal area, which one(s) bypass the liver and deliver blood directly to the systemic circulation?
Antworten
  • The inferior and middle rectal veins
  • The inferior and superior rectal veins
  • The middle and superior rectal veins
  • The inferior, middle and superior rectal veins

Frage 35

Frage
Which of the following is NOT an advantage of drug dosing via rectal route?
Antworten
  • It can be used for unconscious patients
  • Rapid and predictable absorption as compared to other regions of GI tract
  • Hepatic first-pass metabolism may be avoided partially or completely
  • Drugs are not exposed to GI membrane enzymatic activity

Frage 36

Frage
The maximum amount of solid that can normally be incorporated into a suppository is ______ of the blank weight.
Antworten
  • 20%
  • 30%
  • 40%
  • 50%

Frage 37

Frage
While preparing a cocoa butter suppository with other ingredients, the melting point is lowered below that of room temperature. To elevate the melting point of the mixture you will add (select all that apply):
Antworten
  • Chloral hydrate
  • Menthol
  • Camphor
  • Beeswax

Frage 38

Frage
Above what molecular weight do PEG polymers change from liquid to solid ?
Antworten
  • 100
  • 500
  • 1000
  • 5000

Frage 39

Frage
The density factors of four drugs for cocoa butter are given below. For which drug would the greatest weight be required in order to displace 1 g of cocoa butter from a formulation ?
Antworten
  • Aminophylline (1.1)
  • Bismuth subnitrate (6.0)
  • Menthol (0.7)
  • Iodoform (4.0)

Frage 40

Frage
Pharmacist patient-counseling points for proper use of rectal suppositories includes all of the following EXCEPT:
Antworten
  • PEG suppositories should not be stored in polystyrene vials because they react with polystyrene.
  • Before insertion PEG suppositories should be moistened with water.
  • Cocoa butter suppositories should be frozen first and then immediately inserted.
  • Suppositories should be inserted in an adult up to the first knuckle depth (~1 inch).

Frage 41

Frage
Compared to the oral route of administration, all of the following are advantages of the rectal route of administration EXCEPT:
Antworten
  • An effective route for treating nausea and vomiting.
  • Drugs are activated by the pH in the rectum to increase absorption.
  • Useful for administering drugs that cause stomach irritation.
  • Avoids first-pass hepatic deactivation.

Frage 42

Frage
When using cocoa butter suppositories, which of the following drugs will result in the slowest drug release?
Antworten
  • Ionized hydrophilic drug
  • Unionized hydrophilic drug
  • Unionized lipophilic drug
  • Salt form of the drug

Frage 43

Frage
Which of the following is NOT a component of the Lacrimal Apparatus?
Antworten
  • Lacrimal gland
  • Lacrimal ducts
  • Lacrimal sac
  • Lacrimal muscle

Frage 44

Frage
Which layer(s) of the cornea offers the greatest barrier(s) to absorption into the eye for hydrophilic drugs?
Antworten
  • Epithelial layer
  • Stroma
  • Endothelial layer
  • 2 and 3 only

Frage 45

Frage
To prevent possible corneal damage, ophthalmic formulations should be buffered in the pH range of:
Antworten
  • 3.5 to 11.5
  • 4.5 to 10.5
  • 5.5 to 9.5
  • 6.5 to 8.5

Frage 46

Frage
Which of the following is NOT an antioxidant that has been found appropriate for use in ophthalmic formulations?
Antworten
  • Ethylenediaminetetra-acetic acid
  • Sodium Bisulfite
  • Thimerosal
  • Sodium metabisulfite

Frage 47

Frage
pH buffers for ophthalmic solutions are designed and intended to provide all of the following EXCEPT:
Antworten
  • Patient comfort
  • Decreasing systemic absorption
  • Increasing drug stability
  • Increasing drug solubility

Frage 48

Frage
The respiratory region of the nasal cavity is believed to be most suitable for drug delivery because:
Antworten
  • It is poorly supplied with blood vessels
  • It has a relatively large surface area
  • It contains stratified keratinized epithelial cells
  • It directly drains into the lungs

Frage 49

Frage
All of the following statements about nasal drug delivery are true EXCEPT:
Antworten
  • Nasal bioavailability of a drug is typically lower than intravenous bioavailability
  • Nasally administered anesthetic agents can get absorbed by the olfactory region
  • Nasally absorbed drugs can bypass extensive hepatic metabolism
  • Nasal congestion does not affect the bioavailability of the drug
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