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Quiz von mariam Butt, aktualisiert more than 1 year ago
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Erstellt von mariam Butt
vor fast 3 Jahre
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Frage 1
Frage
The graft is a graft from 1 place to another in the same individual
Antworten
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right
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wrong
Frage 2
Frage
Should blood group compatibility between donor and recipient be determined before kidney transplantation
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yes
-
no
Frage 3
Frage
3. Classical MHC class II antigens (HLA-DR, DQ) have a more limited distribution than MHC class I antigens
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yes
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no
Frage 4
Frage
4. The most suitable cells for HLA compatibility testing are lymphocytes derived from the patient's peripheral blood
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yes
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no
Frage 5
Frage
After blood transfusions, pregnancy and previous transplants can form
circulating antibodies
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yes
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no
Frage 6
Frage
The acute rejection reaction of the transplanted organ is manifested:
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3 years
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5-6 months
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up to 3 months
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up to 1-2 weeks
Frage 7
Frage
Rejection of the transplant is a manifestation of
Antworten
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Cell-mediated immunity
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An important process in allograft rejection is humoral-mediated immunity
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Hypersensitivity of type 3 (immune complexes)
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Complement-dependent cytotoxicity
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can damage the graft through its prancreatic enzymes.
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The immune response to the allograft may also include antibodies- igD
Frage 8
Frage
Graft reaction against the host (GVH)
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-It manifests itself in different MHC antigens between donor and recipient
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GVH response does require suppressor T cells
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-May be the result of an infusion of blood products containing viable lymphocytes into immunologically incompetent recipient
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(GVH) is caused by the destruction of cells or tissues of immunocompetent recipient of immunocompetent stem cells
Frage 9
Frage
During transplantation, the preformed cytotoxic antibodies in the recipient
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Are responsible for the super-sharp rejection
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Cytotoxic antibodies of class IgA and IgD lead to an over-acute rejection reaction
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Can be directed against HLA or ABO antigens of the graft
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all are correct
Frage 10
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Immunological follow-up of an organ transplant patient requires examination of
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Changes in lymphocyte populations and subpopulations
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n acute rejection is dominated by CD3 + T lymphocytes
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Donor-specific AT
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Serum levels of cytokines
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serum levels of interferons
Frage 11
Frage
In recipients with repeated kidney transplants, graft survival compared to
that in recipients with a first kidney transplant is:
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reduced
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increased
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recurrent antigenic incompatibilities (especially DR) between donor and recipient in repeated kidney transplants have a positive effect on graft survival.
Frage 12
Frage
Prevention of hemolytic disease of the newborn due to compatibility with maternal Rhesus (RhD) factor includes
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passive maternal immunization to remove Rh antigen
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active maternal immunization to remove Rh antigen
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infusion done after 72hours after the first birth
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infusion of anti-RhD antibodies to the Rh (+) mother
Frage 13
Frage
If the mother develops IgG AT to A and B erythrocyte antigens of the fetus, hemolytic disease of the newborn will appear in children from:
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- 0 mother and AB father
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AB mother and 0 father
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A mother and ab father
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0 mother and A father
Frage 14
Frage
Which of the following AGs are rich in cell membranes of B-lymphocytes
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MHC class II antigens
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MHC class I antigens
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all are correct
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none are correct
Frage 15
Frage
Class III MHC regions in the major human tissue compatibility complex contain genes which encode
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- components of the complement system
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heat shock proteins and cytokines
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none are correct
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components of cellular immunity
Frage 16
Frage
Antimetabolites that suppress the immune response are the purine antagonists are
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involved in dna synthesis
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mercapturin
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azathioprine
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involved in mRna synthesis
Frage 17
Frage
Hypersensitivity graft rejection is associated with
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preformed cytotoxic antibodies
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complement activation
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cellular immunity
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nantural resistance
Frage 18
Frage
The accelerated rejection reaction involves the following immunological factors and
mechanisms of
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sensitized T cells preformed by HLA AT formed during immune response to graft or AZKC
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activated b cells
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complement system
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all are correct
Frage 19
Frage
Molecular genetic methods for HLA typing in clinical transplant practice
include
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elisa
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electrophoresis
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immunoblot
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pcr
Frage 20
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The cells infiltrating the graft in the acute rejection reaction are predominantly
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CD4 +
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CD3 +
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CD16 +
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CD8+
Frage 21
Frage
Allogeneic transplantation
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bone marrow transplantation from mother to daughter
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bone marrow transplantation from daughter to mother
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bone marrow transplantation from mother to son
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bone marrow transplantation from father to daughter
Frage 22
Frage
Autologous transplantation
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transplantation of skin from the thigh to the face of the same individual
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transplantation of skin from the thigh to the face of the different individual
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transplantation of skin from the thigh of a twin to the face of the other twin individual
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done to replace cicatrix for cosmetic procedure
Frage 23
Frage
Syngenna
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bone marrow transplantation from same individual
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bone marrow transplantation between twins
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bone marrow transplantation between family members
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bone marrow transplantation between two compatible donor and recipient
Frage 24
Frage
Sources of stem cells
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serum
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peripheral blood
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pancreas
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umbilical cord
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bone marrow
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epiphysis
Frage 25
Frage
Gene loci of the HLA-class II region (3 correct)
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dp
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rt
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dq
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dr
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ds
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located in the long arm of the sixth chromosome in humans
Frage 26
Frage
Hormones: luteinizing (LH), follicle-stimulating (FSH), inhibin B and estradiol, are tested in serum to assess ovarian reserve in women with reproductive disorders
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yes
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no
Frage 27
Frage
Recurrent abortions are not associated with defects in coagulation factors or circulating anticoagulants (lupus-like anticoagulants)
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correct
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incorrect
Frage 28
Frage
Women with positive anti-ovarian antibodies have an increased chance of becoming pregnant
after birth control in vitro fertilization or embryo transfer compared to women in whom no such was found antibodies
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no
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yes
Frage 29
Frage
Antibodies in women with reproductive disorders are tested by serum
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yes
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no
Frage 30
Frage
Antiphospholipid syndrome is associated with the presence of anticardiolipin antibodies, loss of
fetal, arterial and venous thrombosis
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no
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yes
Frage 31
Frage
which hormone is secreted by the granulosa cells of the ovary and controls the series of
follicle-stimulating hormone from the pituitary gland
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fsh
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lh
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inhibin b
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estradiol
Frage 32
Frage
Which immune indicators are associated with premature decline in ovarian function
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rbc,wbc,anti-dna
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ca19-9, anti phospholipid,antithyroid
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- antiphospholipid, antinuclear, antithyroid and anti-ovarian AT
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none of the above
Frage 33
Frage
The study of the reproductive immunophenotype in women with reproductive problems includes
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T-lymphocytes CD3 +, CD4 +, CD8 +
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B-lymphocytes CD19 +
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NK cells CD3 CD56 +, CD16 +
Frage 34
Frage
Immunological manifestations in patients with endometriosis and reproductive problems are
demonstrated
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increased serum levels of antiphospholipid and antinuclear antibodies
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activated reproductive phenotype and increased NK-cell cytotoxicity
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increase in CA125
Frage 35
Frage
In patients with previous abortions, monitoring and prognosis of the current
pregnancy includes a study of serum concentrations of
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FSH
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- beta human chorionic gonadotropin
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LH
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pituitary gland
Frage 36
Frage
HLA-G antigens are expressed in
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myoblast
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osteoblasts
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trophoblasts
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lymphokines
Frage 37
Frage
The main functions of HLA-G antigens are (SPECIFY THE WRONG ANSWER)
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inhibiting the antitrophoblast activity of maternal NK cells
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protecting the fetus from the mother's immune response against the paternal antigens in it
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inducing frequent abortions
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protection of the fetus from transplant infections
Frage 38
Frage
Elevated NK cells in women with frequent abortions (SPECIFY THE WRONG ANSWER)
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secrete tumor necrosis factor (TNF)
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are examined by peripheral venous blood in an anticoagulant
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are cytotoxic to the placental trophoblast
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they don't matter
Frage 39
Frage
The immunological examination of anti-phospholipid syndrome in pregnant women includes
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- anticardiolipin antibodies
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-antibodies to phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid, phosphatidylglycerol, phosphatidylserine, phosphatidylcholine
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anti-beta-2-glycoprotein I AT
Frage 40
Frage
Anti-ovarian antibodies include AT versus (2 correct)
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antigens of the pellucid zone
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antigens of steroid-producing granulosa-luteinizing cells
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Antibodies against the pellucid zone are also important in specifying cases of cervical cancer
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Antibodies against the pellucid zone are also important in specifying cases of cystic disease.
Frage 41
Frage
The normal development of pregnancy is due to the predominance of
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Th1 cytokines
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Th2 cytokines
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