456616
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor mehr als 10 Jahre
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Frage 1
Frage
What is done in pairwise alignment?
Antworten
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Two sequences are stuck on top of each others and the common areas lined up
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Two sequences are aligned from the beginning and their similarity analysed
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Two sequences are aligned and their similarity analysed
Frage 2
Frage
Local alignment assigns correspondences to all residues in the sequence, leaving gaps if necessary
Antworten
- True
- False
Frage 3
Antworten
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An indel
-
A mismatch
Frage 4
Antworten
- True
- False
Frage 5
Frage
What can sequence identity be used for?
Antworten
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DNA sequence
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Amino acid sequence
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Gene sequence
Frage 6
Frage
Sequence identity can be how specific?
Antworten
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Global
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Local
Frage 7
Frage
What are GAPS?
Antworten
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Spaces in part of the sequence that allows other areas to align better
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Areas with a high density of indels
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Proteins that align when sequences are swapped over
Frage 8
Frage
What is the scoring system that determines an optimal alignment?
Antworten
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+2 Match -1 Indel -2 Mismatch
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+2 Mismatch -1 Match -2 Indel
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+2 Match -1 Mismatch -2 Indel
Frage 9
Frage
Needleman and Wunsch algorithms find the highest scoring path across a matrix
Antworten
- True
- False
Frage 10
Antworten
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Light- Remote homologues Dark - Close homologues
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Light- Close homologues Dark- Remote homologues
Frage 11
Frage
PAM matrices used varies depending on the S.I
Antworten
- True
- False
Frage 12
Frage
PAM250 scoring is used for remote homologues
Antworten
- True
- False
Frage 13
Frage
In PAM250 scoring, scores are given based on what?
Antworten
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The residue rarity
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The properties of the replacing residue- i.e. is one small hydrophobic residue replacing another
Frage 14
Frage
What does BLAST stand for?
Antworten
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Basic Loci Alignment Search Tools
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Basic Loci Alignment Sequencing Tools
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Basic Local Alignment Search Tools
Frage 15
Frage
What is different about BLAST techniques?
Antworten
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The compare residue 'words' instead of single residues/bases
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They work in areas of less than 50bp long
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They cover the whole genome very rapdily
Frage 16
Frage
A 'word' is 3bp or 11 aa long
Antworten
- True
- False
Frage 17
Frage
Once the words have been found in the sequence, they are compared to the database- why?
Antworten
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To find exact matches
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To find evolutionary relationships
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To detect how common the words are
Frage 18
Frage
An E value is expectation, not probability
Antworten
- True
- False
Frage 19
Frage
What is the range and significance for the E value?
Smaller values are more likely
Antworten
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0-10
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1-2
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0-1
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0.5
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5
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0.005
Frage 20
Frage
The E value is the probability of getting a result by change in a database of this size
Antworten
- True
- False
Frage 21
Frage
What is the difference between P and E values
Antworten
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Both are values for 'What is the probability of getting this result by chance alone?', but P accounts for database size
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Both are values for 'What is the probability of getting this result by chance alone?', E accounts for database size
Frage 22
Frage
In P values, <0.05 is significant
Antworten
- True
- False
Frage 23
Frage
P value relies on a normal distribution
Antworten
- True
- False
Frage 24
Frage
What are the limits of P?
Antworten
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0-0.1
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0-1
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0-10
Frage 25
Frage
An E of 4 is equal to - in a database of this size, I could get 4 matches by chance alone
Antworten
- True
- False
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