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Linkage Analysis

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Year 2 Quiz on Linkage Analysis, created by gina_evans0312 on 26/12/2013.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question 1

Question
Metaphase is the most important stage for genetic mapping
Answer
  • True
  • False

Question 2

Question
Recombination cannot be detected in...
Answer
  • Homozygotes
  • Heterozygotes
  • Because both alleles are different
  • Because both alleles are identical

Question 3

Question
What indicates linkage?
Answer
  • The no of recombinants
  • The no of homozygotes
  • The no of heterozygotes

Question 4

Question
A generation bred from parents AB & ab, has 1 recombinant out of 20- is linkage involved
Answer
  • Yes
  • No

Question 5

Question
Recombinant detecting probes can be fooled if double recombination occurs
Answer
  • True
  • False

Question 6

Question
Which of the following gametes tend to recombine more around the centromere?
Answer
  • Spermatocytes
  • Oocytes

Question 7

Question
Oocytes tend to recombine
Answer
  • Around the telomeres
  • Around the centromere
  • More than spermatocytes
  • Less than spermatocytes

Question 8

Question
Most recombination occurs at random
Answer
  • True
  • False

Question 9

Question
What is 1q42.3 referring to?
Answer
  • Short arm of chromosome 1
  • Long arm of chromosome 1
  • Locus position (from telomere to centromere)
  • Locus position (from centromere to telomere)

Question 10

Question
Meiosis is made informative or uninformative depending on whether you can track the diseased allele
Answer
  • True
  • False

Question 11

Question
What must be known for effective meosic analysis?
Answer
  • Grandparent -> Grandchild phenotype
  • Grandchild & all siblings phenotype
  • Parent & all siblings -> Grandchild phenotype

Question 12

Question
Is the following informative for linkage analysis?
Image:
Non-Informative (image/png)
Answer
  • Yes- the child is a recombinant
  • No- the child is heterozygous
  • No- the father is homozygous

Question 13

Question
How would you classify this?
Image:
Informative_Non-Recombinant (image/png)
Answer
  • Uninformative non-recombinant
  • Informative recombinant
  • Informative Non-recombinant

Question 14

Question
This is an informative recombinant
Image:
Informative_Recombinant (image/png)
Answer
  • True
  • False

Question 15

Question
What is true of Recombinant/Human Pedigree Analysis?
Answer
  • The lower the recombination frequency, the more likely the hypothysis is to be correct
  • The higher the recombination frequency, the more likely the hypothysis is to be correct

Question 16

Question
A mother has a disease, and has the alleles M1 & M2- what are the two hypothesis for pedigree analysis?
Answer
  • M1 is diseased M2 is healthy
  • M1 is healthy M2 is diseased
  • M1 & M2 are healthy
  • M1 & M2 are diseased

Question 17

Question
Give the two Recombination frequencies for that above image
Image:
Recombinant_Analysis (image/png)
Answer
  • 0.16 & 0.83
  • 1.66 & 8.33
  • 16.66 & 83.33

Question 18

Question
A higher recombination frequency means alleles are closer together
Answer
  • True
  • False

Question 19

Question
Define a Marker
Answer
  • Any mendelian character that can be used to follow a disease through a pedigree
  • A fluorescent dye used to find particular alleles
  • A mutagen used to create findable mutations
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