chirality

Beschreibung

chirality in drug design
Sam Watkins
Quiz von Sam Watkins, aktualisiert more than 1 year ago
Sam Watkins
Erstellt von Sam Watkins vor etwa 8 Jahre
152
0

Zusammenfassung der Ressource

Frage 1

Frage
enantiomers are non identical mirror images with a plane of symettry
Antworten
  • True
  • False

Frage 2

Frage
enantiomers are a pair of stereoisomers that are non identical mirror images of eachother
Antworten
  • True
  • False

Frage 3

Frage
diastereoisomers are
Antworten
  • a pair of non identical stereoisomers that are not mirror images of eachother
  • a pair of non identical stereoisomers that are mirror images of eachother
  • a pair of identical mirror images with a plane of symettry

Frage 4

Frage
when describing chiral centres.. (select all that are true)
Antworten
  • R/S classifies a chiral centre by the groups around it
  • D/L classifies a chiral centre by comparison to a reference compound glyceraldehyde
  • d/l classifies a molecule by the direction it rotates polarised light d is clockwise
  • +/- is the same as R/S. R = + S = -

Frage 5

Frage
Biosynthesis (synthesis of molecules in a biological system) is often stereoselective
Antworten
  • True
  • False

Frage 6

Frage
Chiral synthesis in the laboratory is often very [blank_start]difficult[blank_end]. It is even harder to scale up to industrial scale. Two approaches to obtaining pure chiral molecules are [blank_start]Chiral separation[blank_end] (use a physical method e.g chromatography to separate the desired stereoisomer from a mixture) and [blank_start]The Chiral Pool[blank_end] (use a starting material that already contains a chriral centre.)
Antworten
  • difficult
  • straightforward
  • fast
  • Chiral separation
  • chiral synthesis
  • HPLC/MS
  • The Chiral Pool
  • The chemical pool
  • chiral separation
  • chiral splitting

Frage 7

Frage
about 25% of drugs are administered as a racemate - an equal mixture of stereoisomers
Antworten
  • True
  • False

Frage 8

Frage
some drugs are given as a single isomer which means a larger dose is required
Antworten
  • True
  • False

Frage 9

Frage
which of the following is FALSE
Antworten
  • for a pair of stereoisomers the one with the greater activity is the eutomer
  • for a pair of stereoisomers the one with the lesser activity is the distomer
  • the ratio between the distomer and the eutomer is the disumic ratio

Frage 10

Frage
select which apply about the ADME of stereoisomers:
Antworten
  • during ABSORPTION by transmembrane proteins stereoisomers of chiral drugs can absorb differently
  • during ABSORPTION by passive diffusion stereoisomers of chiral drugs absorb differently
  • DISTRIBUTION leads to the stereoisomers having different effects because they bind to the plasma proteins
  • METABOLISM causes stereoisomers to be the broken down same as the same enzymes are used for both R and S forms of the drug

Frage 11

Frage
The development of a [blank_start]single[blank_end] isomer drug from a previously marketed [blank_start]racemate[blank_end] is known as the [blank_start]chiral switch[blank_end]
Antworten
  • single
  • R-
  • multi
  • racemate
  • eutomer
  • tablet
  • distomer
  • chiral switch
  • chiral pool
  • chiral centre

Frage 12

Frage
which are advantages of the chiral switch?
Antworten
  • improved biological activity
  • opportunity to market a new product
  • reduced side effects
  • simpler pharmacokinetics
Zusammenfassung anzeigen Zusammenfassung ausblenden

ähnlicher Inhalt

AQA GCSE Product Design Questions
Bella Statham
ART NOUVEAU
Britknee52
How Sewing Machines Work
faithkateridarli
Costume History Slidshow
Jemi Armstrong
Product Design
adamwood451
PHARMACOLOGY BLOCK 1- basic intro
wallacejr@hotmail.co
A LEVEL PRODUCT DESIGN - MODERN MANUFACTURING SYSTEMS
charlotte-clayto
GCSE Textiles - Design
Nicola Lees
PUBLIC HEALTH
Zinab Keshk
Exam 1 Medications
tera_alise