7990396
Frage 1
Frage
By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a
finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the
minimum number of phases present in a dispersed system?
Antworten
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1
-
2
-
3
Frage 2
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The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of
the dispersed phase?
Antworten
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Solid state
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Particle size
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Molecular weight
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Chemical structure
Frage 3
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Why might a dispersed phase containing drug be formulated in a dispersion medium in which it
was insoluble?
Antworten
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To increase the solubility
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To mask bitter tastes
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To increase the viscosity
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To decrease the viscosity
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None of the above
Frage 4
Frage
Given the equation for Stoke’s law of settling below, by how much you have to increase the
viscosity to offset a particle size increase of a factor of two?
Antworten
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Factor of 1/2
-
Factor of 2
-
Factor of 4
Frage 5
Frage
Given a suspension with a fixed particle size distribution, what would be true if each powder
particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of
dispersion medium)?
Antworten
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The viscosity would be infinite
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The settling rate will be very high
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The settling rate would be zero
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The particle size would approach colloidal dimensions
Frage 6
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The primary mechanism of altering dispersion medium properties is modification of:
Antworten
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Density
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Viscosity
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Dielectric constant
Frage 7
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Which of the following characteristics is NOT desirable in the case of suspension dosage forms?
Antworten
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Flocculation with formulation of loosely bound aggregates
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Flocculation with formulation of strongly bound aggregates
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Formation of loose sediment
Frage 8
Frage
An advantage of a shear thinning formulation includes:
Antworten
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Ease of mixing with relatively mild shaking of the container
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Lower viscosity on standing to prevent settling
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Caking of needle shaped particles
Frage 9
Frage
Under what conditions would you compound a suspension using benzyl alcohol or propylene
glycol for preemies?
Antworten
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Only for acute usage
-
Only for antibiotics
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Never
Frage 10
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You are asked to compound a suspension of a drug normally dispensed as a solid dosage form.
Why is it prudent to determine if a liquid dosage form is also commercially available?
Antworten
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You can save the effort and advise the patient they must wait until you can order the commercial dosage form
-
If a commercial liquid dosage form isn’t available, it may indicate a potential chemical stability problem
-
If a commercial liquid dosage form isn’t available, it may indicate a potential physical stability problem
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Both B and C
Frage 11
Frage
Select the choices that correctly fill the blanks in the following statement: the three minimum
requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) ____ 2)____ 3)____.
Antworten
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1) Components forming at least 2 phases, 2) a component to stabilize the interface between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
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1) At least one solid component 2) amphiphilic surfactant molecules, 3) adjustment to physiologic pH
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1) Component forming liquid crystalline phases, 2) a component to overcome the “double layer between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
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All of the above
Frage 12
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Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically
unstable?
Antworten
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Dispersed phase tends to form aggregates of globules on standing
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Aggregates of the dispersed phase may be re-dispersed by shaking
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Large globules or aggregates of globules rise to the top or fall to the bottom of container forming a concentrated layer of dispersed phase
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All or part of the liquid in the dispersed phase separates to form a distinct layer
Frage 13
Frage
Patients should virtually never be instructed to store an emulsion dosage form:
Antworten
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In the refrigerator
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At room temperature
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In the freezer
Frage 14
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The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase
in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of
Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):
Antworten
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72 and 28% respectively
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28 and 72% respectively
-
None of the above
Frage 15
Frage
A magma is a:
Antworten
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Two phase gel in which the gel mass does not consists of floccules of small distinct particles
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One phase gel in which the gel mass consists of floccules of small distinct particles
-
Two phase gel in which the gel mass consist of floccules of small distinct particles
Frage 16
Frage
In a colloidal dispersion the particle size is:
Antworten
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Much smaller than typical molecule dimensions
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Much larger than typical molecule dimensions
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The same or smaller than typical molecule dimensions
Frage 17
Frage
Which of following is FALSE in case of gel formulation exhibiting syneresis?
Antworten
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A measurable increase in volume of Gel
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A non-measurable change in the volume of Gel
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A measureable decrease in volume of Gel
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A and B
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B and C
Frage 18
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What is a major function of glycerin in the carboxymethylcellulose based gel formulations?
Antworten
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To prevent drying of Gel
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Sweetner
-
Antioxidant
Frage 19
Frage
Which of following if true of aerosol used to provide an airborne mist?
Antworten
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Particle size >50μm
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Particle size <50 μm
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Particle size <1μm
-
None of above
Frage 20
Frage
A properly prepared pharmaceutical suspension should settle slowly and should readily re
dispersed upon gentle shaking on the container
Antworten
- True
- False
Frage 21
Frage
Which of the following excipients should not be used in the formulation of a Carboxymethylcellulose-based gel?
Antworten
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Preservative
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Glycerin
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Alcohol
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None of the above
Frage 22
Frage
Stability is an important consideration in the formulation of emulsions. Which of the following represents an irreversible phenomenon in terms of re-dispersion of emulsion?
Antworten
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Creaming
-
Coalescence of droplets
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Flocculation
-
None of the above
Frage 23
Frage
Given that the API is soluble in water, which of the following type of emulsion is desirable to formulate?
Antworten
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O/W
-
W/O
-
None of the above
Frage 24
Frage
When you decrease the particle size of disperse phase by factor of 10, then the settling velocity will decrease by a factor of:
Antworten
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10
-
100
-
1000
Frage 25
Frage
What is a primary reason to formulate the powders for suspension?
Antworten
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To facilitate transport and ease of administration
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Maintain the stability of API
-
Improve patient compliance
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