HPA - Lactulose | Karteikarten

Frage	Antworten
What is it?	An osmotic laxative
Trade names	Actilax, Duphalac, Genlac, Lac-Dol, Lactour
Pharmacological class	Glycoside
Indications	Chronic constipation hyperammonemia ( caused by hepatic encephalopathy)
Action	Produces an osmotic effect in colon; resulting distension promotes peristalsis. Also decreases blood ammonia level by drawing ammonia from circulation into the colon and through the GIT
Therapeutic effects	Softens stools and removes ammonia from circulation
Absorption and distribution	ABSORPTION: poorly absorbed by GIT DISTRIBUTION: primarily in the colon
Metabolism & excretion	metabolised in the colon by enteric bacteria. Fecal excretion
Half life	1.7 - 2 hours
Precaution	Contraindicated in individuals on low-galactose or lactose-free diets Use cautiously in individuals with DM Be prepared to replace fluid loss
Side effects	Abdominal cramping, flatulence, nausea and vomiting, diarrhoea, dehydration and electrolyte disturbances
Interactions	Antacids, antibiotics: decreased effectiveness of lactulose. Avoid use together.
Education	Instruct patient not to take other laxatives Encourage person to exercise, as tolerated Advise patient to notify prescriber if diarrhoea occurs Educate patient regarding dietary fiber Tell patient to keep up fluids

HPA - Lactulose

	Erstellt von Em J vor fast 6 Jahre