Antifungals

Beschreibung

Random notes on antifugnals; mostly generalized info
Justin Veazey
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Justin Veazey
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Antifungal agent A drug that selective eliminates fungal pathogens
Antifungal relation to Antibacterial? There are far less antifungal agents than antibacterial agents
Major/examples antifungal agents Polyene macrolides Imidazoles Flucytosine Griseofulvin Iodides
Polyene macrolides; Drug names Amphotericin B Nystatin Pimaricin (natamycin)
Polyene macrolides; Mode of Action Bing Sterol-components in phospholipid sterol membranes. [Disrupts membranes]
What's unique about Polyene macrolides at a pH between 6-7.3 Fungicidal>fungistatic
When do you use Amphotericin B? Principally; Systemic mycotic infections
Tx?; Nystatin [Polyene macrolide] Tx/Nystatin: Mucocutaneous (skin, oropharynx, vagina) or Intestinal Candidiasis
Tx:Pimaricin? [Polyene macrolides] Pimaricin: Therapeutic management of mycotic keratitis
Imidazoles-uses Anti-bacterial, Anti-fungal, Anti-protozoal, Anti-helmintic activity
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