PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

Question 1 of 13

1

Select from the dropdown lists to complete the text.

( Decreased, Increased ) serum Calcium – sensed by Calcium-sensing Receptor (CaR) in the ( ParaThyroid Gland, Hypothalamus, Thyroid Gland ) triggers release of PTH.

Explanation

Question 2 of 13

1

In response to decreased serum Calcium, PTH is released and goes to which of the following?

Select one or more of the following:

Kidney
Bone
Gut
Muscle
Liver

Explanation

Question 3 of 13

1

Select from the dropdown lists to complete the text.

In the kidney, what PTH has 3 effects. These are:
a: ( Increase, Decrease ) 1,25 (OH)2 D;
b: ( Increase, Decrease ) Ca reabsorption;
c: ( Increase, Decrease ) PO4 reabsorption;

Explanation

Question 4 of 13

1

Select from the dropdown lists to complete the text.

In the bone, PTH has 2 effects. These are:
a: ↑ ( Osteoclasts, Osteoblasts, Osteocytes, Lining Cells );
b: ↑ Bone ( Resorption, Formation ) (releasing Ca).

Explanation

Question 5 of 13

1

PTH-1 is a class-B GPCR. Yeah?

Select one of the following:

Yeah
Nah

Explanation

Question 6 of 13

1

The primary effect of Hyperparathyroidism is:

Select one of the following:

Increase blood Ca
Decrease blood Ca
Increase kidney Ca
Decrease kidney Ca

Explanation

Question 7 of 13

1

PROLONGED increase of PTH results in which of the following:

Select one or more of the following:

Increased osteoclasts
Decreased osteoclasts
Increased osteocytes
Decreased osteocytes
Increased bone resorption
Increased bone formation
Bone loss
Bone gain

Explanation

Question 8 of 13

1

The main effect of INTERMITTENT PTH is:

Select one or more of the following:

Increased osteoblast numbers
Increased osteoclast numbers
Decreased osteoblast numbers
Decreased osteoclast numbers

Explanation

Question 9 of 13

1

True or false: Intermittent PTH has little effect on osteoclasts, although they are necessary for its action.

Select one of the following:

True
False

Explanation

Question 10 of 13

1

Select from the dropdown list to complete the text.

Sclerostin is a ( Negative, Positive ) regulator of bone formation.

Explanation

Question 11 of 13

1

Select from the dropdown list to complete the text.

Mutations that inactivate Sclerostin cause ( Increased, Decreased ) bone mass.

Explanation

Question 12 of 13

1

Sclerostin is produced by which of the following:

Select one or more of the following:

Osteocytes
Osteoclasts
Osteoblasts
Lining Cells
PTH

Explanation

Question 13 of 13

2

Select from the dropdown lists to complete the text.

Intermittent PTH ( Decreases, Increases ) sclerostin. Sclerostin ( Inhibits, Stimulates ) Wnt signaling. Therefore Intermittent PTH has a ( Positive, Negative ) effect on Wnt signalling and results in ( Increased, Decreased ) bone formation (and ( Decreased, Increased ) bone resorption).

	Created by Michael Jardine over 6 years ago

PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

Question 1 of 13

Select from the dropdown lists to complete the text.

Decreased Increased( Decreased, Increased ) serum Calcium – sensed by Calcium-sensing Receptor (CaR) in the ParaThyroid Gland Hypothalamus Thyroid Gland( ParaThyroid Gland, Hypothalamus, Thyroid Gland ) triggers release of PTH.

Explanation

Question 2 of 13

In response to decreased serum Calcium, PTH is released and goes to which of the following?

Select one or more of the following:

Explanation

Question 3 of 13

Select from the dropdown lists to complete the text.

In the kidney, what PTH has 3 effects. These are: a: Increase Decrease( Increase, Decrease ) 1,25 (OH)2 D; b: Increase Decrease( Increase, Decrease ) Ca reabsorption; c: Increase Decrease( Increase, Decrease ) PO4 reabsorption;

Explanation

Question 4 of 13

Select from the dropdown lists to complete the text.

In the bone, PTH has 2 effects. These are: a: ↑ Osteoclasts Osteoblasts Osteocytes Lining Cells( Osteoclasts, Osteoblasts, Osteocytes, Lining Cells ); b: ↑ Bone Resorption Formation( Resorption, Formation ) (releasing Ca).

Explanation

Question 5 of 13

PTH-1 is a class-B GPCR. Yeah?

Select one of the following:

Explanation

Question 6 of 13

The primary effect of Hyperparathyroidism is:

Select one of the following:

Explanation

Question 7 of 13

PROLONGED increase of PTH results in which of the following:

Select one or more of the following:

Explanation

Question 8 of 13

The main effect of INTERMITTENT PTH is:

Select one or more of the following:

Explanation

Question 9 of 13

True or false: Intermittent PTH has little effect on osteoclasts, although they are necessary for its action.

Select one of the following:

Explanation

Question 10 of 13

Select from the dropdown list to complete the text.

Sclerostin is a Negative Positive( Negative, Positive ) regulator of bone formation.

Explanation

Question 11 of 13

Select from the dropdown list to complete the text.

Mutations that inactivate Sclerostin cause Increased Decreased( Increased, Decreased ) bone mass.

Explanation

Question 12 of 13

Sclerostin is produced by which of the following:

Select one or more of the following:

Explanation

Question 13 of 13

Select from the dropdown lists to complete the text.

Explanation

( Decreased, Increased ) serum Calcium – sensed by Calcium-sensing Receptor (CaR) in the ( ParaThyroid Gland, Hypothalamus, Thyroid Gland ) triggers release of PTH.

In the kidney, what PTH has 3 effects. These are:
a: ( Increase, Decrease ) 1,25 (OH)2 D;
b: ( Increase, Decrease ) Ca reabsorption;
c: ( Increase, Decrease ) PO4 reabsorption;

In the bone, PTH has 2 effects. These are:
a: ↑ ( Osteoclasts, Osteoblasts, Osteocytes, Lining Cells );
b: ↑ Bone ( Resorption, Formation ) (releasing Ca).

Sclerostin is a ( Negative, Positive ) regulator of bone formation.

Mutations that inactivate Sclerostin cause ( Increased, Decreased ) bone mass.