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Biochemistry - PreMidterm (Lecture 27 - Pyruvate Dehydrogenase and Citric Acid Cycle) Quiz on Biochemistry - Lecture 27 - Pyruvate Dehydrogenase and Citric Acid Cycle, created by GCS3 on 02/19/2014.

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Biochemistry - Lecture 27 - Pyruvate Dehydrogenase and Citric Acid Cycle

Biochemistry - Lecture 27 - Pyruvate Dehydrogenase and Citric Acid Cycle

Question 1 of 14 Question 1 of 14

1

In aerobic respiration, where is the pyruvate dehydrogenase complex located in Eukaryotes?

Select one of the following:

  • Intermembrane space of mitochondria

  • Matrix of mitochondria

  • Inner membrane of mitochondria

  • Outer membrane of mitochondria

  • Cytosol of the cell

Explanation

Question 2 of 14 Question 2 of 14

1

What activates pyruvate dehydrogenase complex?

Select one of the following:

  • Glucagon in adipocytes and liver

  • protein kinase

  • phosphorylation

  • dephosphorylation

  • acetyl CoA

Explanation

Question 3 of 14 Question 3 of 14

1

What coenzymes are necessary for pyruvate dehydrogenase complex?

Select one of the following:

  • thiamine, riboflavin, pantothenic acid, niacin, lipoic acid

  • PDH, NAD+, FAD, TPP, lipoic acid

  • pyruvate decarboxylase, NAD+, FAD, TPP, lipoic acid

  • pyruvate dehydrogenase, dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase

  • nicotinamide adenine dinucleotide, flavin adenine dinucleotide, coenzme A-SH, lipoic acid, thiamine pyrophosphate

Explanation

Question 4 of 14 Question 4 of 14

1

From what FOUR vitamins are the coenzymes of the PDH complex derived?

Select one of the following:

  • Thiamine, Vitamin B1, Riboflavin, Vitamin B2

  • Thiamine, Riboflavin, Niacin, Vitamin B1

  • Niacin, Riboflavin, Vitamin C, lipoic acid

  • Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B5

  • Vitamin B12, Vitamin B3, Vitamin B6, thiamine

Explanation

Question 5 of 14 Question 5 of 14

1

In the TCA, which enzymes catalyze forward reactions producing NADH?

Select one of the following:

  • Citrate synthase, malate dehydrogenase, ketoglutarate dehydrogenase

  • Aconitase, Fumarase, Syccinyl CoA synthetase, Isocitrate dehydrogenase

  • Isocitrate dehydrogenase, succinyl CoA synthetase, ketoglutarate dehydrogenase

  • Isocitrate dehydrogenase, malate dehydrogenase, ketoglutarate dehydrogenase

  • Isocitrate dehydrogenase, succinate dehydrogenase, ketoglutarate dehydrogenase

Explanation

Question 6 of 14 Question 6 of 14

1

Carbon dioxide is released in two reactions of the TCA. Which two substrates are produced as a result of the decarboxylation reaction?

Select one of the following:

  • Succinyl CoA, Succinate

  • Citrate, alpha-ketoglutarate

  • Isocitrate, L-Malate

  • Citrate, Fumarate

  • alpha-ketoglutarate, Succinyl CoA

Explanation

Question 7 of 14 Question 7 of 14

1

Which enzymes of the TCA are regulated?

Select one of the following:

  • Citrate dehydrogenase, isocitrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • Malate dehydrogenase, citrate synthase, ketoglutarate dehydrogenase, isocitrate dehydrogenase

  • ketoglutarate dehydrogenase, fumarase, aconitase, succinate dehydrogenase

  • citrate synthase, isocitrate dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • succinate thiokinase, citrate synthase, fumarase, aconitase

Explanation

Question 8 of 14 Question 8 of 14

1

Which enzymes are regulated by Ca2+, ATP and NADH?

Select one of the following:

  • Citrate synthase, Isocitrate Dehydrogenase, succinate dehydrogenase

  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • Citrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase

Explanation

Question 9 of 14 Question 9 of 14

1

What enzymes in the TCA are regulated by other substrates?

Select one of the following:

  • Citrate synthase, Isocitrate Dehydrogenase, succinate dehydrogenase

  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase

  • Citrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase

Explanation

Question 10 of 14 Question 10 of 14

1

What enzymes of the TCA are regulated by ADP?

Select one of the following:

  • Citrate synthase, Isocitrate Dehydrogenase, succinate dehydrogenase

  • Citrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase

  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase

Explanation

Question 11 of 14 Question 11 of 14

1

List a cause, symptom and metabolic effect, respectively, of Werneke-Korsakoff syndrome.

Select one of the following:

  • thiamine deficiency, memory loss, and lactic acidosis

  • niacin deficiency, heart failure, increase NADH

  • riboflavin deficiency, ataxia (lack of voluntary muscle control), decreased pyruvate

  • thiamine deficiency, cerebral hemorrhage, uncoupled ETC

  • riboflavin deficiency, wet beri-beri, increased ATP

Explanation

Question 12 of 14 Question 12 of 14

1

What is the mechanism of arsenic poisoning?

Select one of the following:

  • Inhibits pyruvate decarboxylase by binding to pyruvate.

  • Inhibits dihydrolipoyl dehydrogenase by binding to FAD.

  • Inhibits ketoglurate dehydrogenase by binding to alpha-ketoglutarate.

  • Inhibits PDH by binding to TPP.

  • Inhibits dihydrolipoyl transacetylase by binding to lipoic acid.

Explanation

Question 13 of 14 Question 13 of 14

1

What enzyme is inhibited by fluorocitrate?

Select one of the following:

  • aconitase

  • fumarase

  • malonate dehydrogenase

  • alpha-ketoglutarate dehydrogenase

  • succinate dehydrogenase

Explanation

Question 14 of 14 Question 14 of 14

1

What vitamin deficiencies result in malfunctions of the tricarboxylic acid cycle?

Select one of the following:

  • Vitamins B1, B2, B3, B5, B12

  • NAD+, FAD, lipoic acid, coenzyme A, thiamine pyrophosphate

  • niacin, riboflavin, nicotinamide, malonate, vitamin B12

  • niacin, riboflavin, thamine, pantothenate, lipoic acid

  • Niacin, vitamin B3, thiamine, vitamin B1, lipoic acid

Explanation

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