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Biochemistry - Lecture 27 - Pyruvate Dehydrogenase and Citric Acid Cycle

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Biochemistry - PreMidterm (Lecture 27 - Pyruvate Dehydrogenase and Citric Acid Cycle) Quiz on Biochemistry - Lecture 27 - Pyruvate Dehydrogenase and Citric Acid Cycle, created by GCS3 on 19/02/2014.
GCS3
Quiz by GCS3, updated more than 1 year ago
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Created by GCS3 almost 12 years ago
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Question 1

Question
In aerobic respiration, where is the pyruvate dehydrogenase complex located in Eukaryotes?
Answer
  • Inner membrane of mitochondria
  • Outer membrane of mitochondria
  • Matrix of mitochondria
  • Cytosol of the cell
  • Intermembrane space of mitochondria

Question 2

Question
What activates pyruvate dehydrogenase complex?
Answer
  • phosphorylation
  • dephosphorylation
  • acetyl CoA
  • protein kinase
  • Glucagon in adipocytes and liver

Question 3

Question
What coenzymes are necessary for pyruvate dehydrogenase complex?
Answer
  • nicotinamide adenine dinucleotide, flavin adenine dinucleotide, coenzme A-SH, lipoic acid, thiamine pyrophosphate
  • PDH, NAD+, FAD, TPP, lipoic acid
  • pyruvate dehydrogenase, dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase
  • pyruvate decarboxylase, NAD+, FAD, TPP, lipoic acid
  • thiamine, riboflavin, pantothenic acid, niacin, lipoic acid

Question 4

Question
From what FOUR vitamins are the coenzymes of the PDH complex derived?
Answer
  • Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B5
  • Niacin, Riboflavin, Vitamin C, lipoic acid
  • Vitamin B12, Vitamin B3, Vitamin B6, thiamine
  • Thiamine, Vitamin B1, Riboflavin, Vitamin B2
  • Thiamine, Riboflavin, Niacin, Vitamin B1

Question 5

Question
In the TCA, which enzymes catalyze forward reactions producing NADH?
Answer
  • Aconitase, Fumarase, Syccinyl CoA synthetase, Isocitrate dehydrogenase
  • Isocitrate dehydrogenase, succinyl CoA synthetase, ketoglutarate dehydrogenase
  • Isocitrate dehydrogenase, succinate dehydrogenase, ketoglutarate dehydrogenase
  • Isocitrate dehydrogenase, malate dehydrogenase, ketoglutarate dehydrogenase
  • Citrate synthase, malate dehydrogenase, ketoglutarate dehydrogenase

Question 6

Question
Carbon dioxide is released in two reactions of the TCA. Which two substrates are produced as a result of the decarboxylation reaction?
Answer
  • Isocitrate, L-Malate
  • Succinyl CoA, Succinate
  • alpha-ketoglutarate, Succinyl CoA
  • Citrate, alpha-ketoglutarate
  • Citrate, Fumarate

Question 7

Question
Which enzymes of the TCA are regulated?
Answer
  • ketoglutarate dehydrogenase, fumarase, aconitase, succinate dehydrogenase
  • Malate dehydrogenase, citrate synthase, ketoglutarate dehydrogenase, isocitrate dehydrogenase
  • Citrate dehydrogenase, isocitrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • citrate synthase, isocitrate dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • succinate thiokinase, citrate synthase, fumarase, aconitase

Question 8

Question
Which enzymes are regulated by Ca2+, ATP and NADH?
Answer
  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • Citrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase
  • Citrate synthase, Isocitrate Dehydrogenase, succinate dehydrogenase

Question 9

Question
What enzymes in the TCA are regulated by other substrates?
Answer
  • Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase
  • Citrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • Citrate synthase, Isocitrate Dehydrogenase, succinate dehydrogenase

Question 10

Question
What enzymes of the TCA are regulated by ADP?
Answer
  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • Citrate synthase, Isocitrate Dehydrogenase, succinate dehydrogenase
  • Citrate synthase, Isocitrate Dehydrogenase, ketoglutarate dehydrogenase
  • Isocitrate Dehydrogenase, ketoglutarate dehydrogenase, succinate dehydrogenase
  • Citrate synthase, ketoglutarate dehydrogenase, succinate dehydrogenase

Question 11

Question
List a cause, symptom and metabolic effect, respectively, of Werneke-Korsakoff syndrome.
Answer
  • thiamine deficiency, memory loss, and lactic acidosis
  • riboflavin deficiency, wet beri-beri, increased ATP
  • niacin deficiency, heart failure, increase NADH
  • thiamine deficiency, cerebral hemorrhage, uncoupled ETC
  • riboflavin deficiency, ataxia (lack of voluntary muscle control), decreased pyruvate

Question 12

Question
What is the mechanism of arsenic poisoning?
Answer
  • Inhibits ketoglurate dehydrogenase by binding to alpha-ketoglutarate.
  • Inhibits dihydrolipoyl transacetylase by binding to lipoic acid.
  • Inhibits PDH by binding to TPP.
  • Inhibits pyruvate decarboxylase by binding to pyruvate.
  • Inhibits dihydrolipoyl dehydrogenase by binding to FAD.

Question 13

Question
What enzyme is inhibited by fluorocitrate?
Answer
  • alpha-ketoglutarate dehydrogenase
  • succinate dehydrogenase
  • aconitase
  • malonate dehydrogenase
  • fumarase

Question 14

Question
What vitamin deficiencies result in malfunctions of the tricarboxylic acid cycle?
Answer
  • Vitamins B1, B2, B3, B5, B12
  • niacin, riboflavin, thamine, pantothenate, lipoic acid
  • NAD+, FAD, lipoic acid, coenzyme A, thiamine pyrophosphate
  • niacin, riboflavin, nicotinamide, malonate, vitamin B12
  • Niacin, vitamin B3, thiamine, vitamin B1, lipoic acid
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