1777239
Description
Flashcards by aliroussel, updated more than 1 year ago
|
Created by aliroussel
almost 12 years ago
|
|
| Question | Answer |
| SN2 Leaving Groups | TosO, I, Br, Cl |
| SN2 Solvents | HMPA, CH3CN, DMF, DMSO Polar aprotic surround the cation but not the nucleophile |
| SN2 Substrates | Methyl, 1*, 2*, 3* due to steric hinderance and its role in mechanism |
| SN1 Substrates | 3*, 2*=Benzyl=allylic, 1*, methyl |
| SN1 Leaving Group | H20, TosO=I, Br, Cl, OH Easily removable for carbocation formation |
| SN1 Nucleophile | Does not effect reaction rate Non basic to prevent elimination |
| SN1 Solvent | H2O, Water/Ethanol, Ethanol Stabilizes carbocation |
| E2 Definition | Alkyl Halide + Strong Base No intermediates Periplanar geometry non-Zaitsev product in rings |
| Zaitsev's Rule | More substituted alkene will form |
| E1 Reaction | Alkyl Halide + Strong Base Carbocation formed Base forces loss of adjacent hydrogen and formation of double bond |
| E1 and SN1 happen together with... | Protic solvent nonbasic nucleophile both reactions have the same preferable substrates |
| Primary Alkyl Halides | SN2 if good nucleophile (regular strong base, negative) E2 f strong sterically hindered base |
| SN2 Nucleophile | Basic, negatively charged nucleophiles |
Want to create your own Flashcards for free with GoConqr? Learn more.