3818318
| Question | Answer |
| LOSARTAN Very selective angiotensin receptor antagonist works in AT1 on AG2 orally efficacious 50 mg qd (maintenance 25-100mg) effective in reducing ACE cough | |
| VALSARTAN Angiotensin Receptor Antagonist predominantly AT1 80-320mg/day | |
| Irbesartan 150-300mg/day | |
| CANDESARTAN as low as 2mg/day (typically 8-32mg) good bioavailability cascading prodrug 67% feces 33% urine dont need renal fnc to elim | |
| TELMISARTAN carboxylate gives it affinity a little more potent 20-80mg/day | |
| EPROSARTAN AT1 blocker 400-800mg/day no particular benefit | |
| OLMESARTAN Cascading prodrug used w/o adjustment in renal or hepatic problems 50/50 in urine and deces .3-.5% angioedema (greater with ACE inhibitors) but can be life threatening | |
| OMAPATRILAT | |
| ALISKIREN 150-300mg/day orally or in cominations not in 2nd and 3rd trimester (affects kidney development in fetus) | |
| RESERPINE Inhibition of active transport of NE into storage vesicles post ganglionic sympathetic inhibition depression is a big side effect |
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