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PROTO-ONCOGENES

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Cancer Biology Mind Map on PROTO-ONCOGENES, created by salu624 on 26/10/2013.
salu624
Mind Map by salu624, updated more than 1 year ago
salu624
Created by salu624 over 10 years ago
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Resource summary

PROTO-ONCOGENES
  1. ONCOGENE
    1. MUTATION
      1. POINT
        1. DELETION
        2. CHROMOSOMAL TRANSLOCATION
          1. AMPLIFICATION
          2. GROWTH FACTORS/RECEPTORS
            1. INTERLEUKIN-2 (CYTOKINE)
              1. T-CELL LEUKEMIAS
              2. HER2/NEU (EGF)
                1. BREAST CANCER
                2. EGFR (TK INHIBITOR)
                  1. GEFITINIB
                3. SIGNALING PROTEINS
                  1. B-Raf MUTATION (MAPKKK)
                    1. MELANOMA
                    2. bcr-abl MUTATION
                      1. CML
                        1. GLEEVEC
                      2. TRANSCRIPTION FACTORS
                        1. Myc (Ras-MAPK pathway)
                          1. LATE NEUROBLASTOMAS
                            1. B-CELL LYMPHOMAS
                          2. CELL CYCLE PROTEINS
                            1. MULTIPLE COPES OF CYCLIN D GENE
                            2. ANTI-APOPTOTIC PROTEINS
                              1. OVER-EXPRESSION OF BCL-2
                                1. CHRONIC LYMPHOBLASTIC LYMPHOMA
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