PHARMACOLOGICAL ASPECTS OF HYPOTHALAMUS / PITUITARY & ADRENAL DISORDERS

physiology
Growth Hormone
1. somatropin,somatrem(synthetic analog)
2. To improve growth in children with GH deficiency
3. Adverse
  1. Carpal tunnel syndrome, hyperglycemia
4. Somatostatin
  1. Somatotropin releasing inhibiting hormone
  2. Synthetic
    1. 1 Octreotide 2 Pegvisomant
    2. uses
      1. Acromegaly. Carcinoid tumors. Pancreatic tumors
    3. Adverse
      1. sludge(gallstone)
ERGOT DERIVATIVES (DOPAMINE AGONIST (D2)
1. Decrease prolactin
2. Bromocriptine
3. USES
  1. Hyperprolactinemia
  2. Parkinsonism
4. effecs
  1. syncope,postural hypotension, psychosis
Vassopressin
1. ADH
2. Uses
  1. Neurogenic DI(pituitary)(central DI)
  2. Nephrogenic DI(impaired renal response to AVP)
  3. Constrict blood vessel
3. Adverse
  1. coronary vasospasm
  2. uterine contraction
Desmopressin
1. selective (V2) agonist
2. Uses
  1. DI(Central,pituitary)(DOC) Bedwetting(children)
Adenocorticosteroids
1. MAGIC drug
  1. Synthesis
  2. uses
    1. ALL Disease usable
      1. Neurologic diseases
      2. Pulmonary diseases
      3. Renal disease
2. Immunosuppression
3. TOXICITY
  1. Acute withdrawal
    1. cerebral edema
    2. fever, myalgia
  2. Prolonged usage
    1. fluid/lyte disturbances, hypertension, hyperglycemia, glycosuria
    2. peptic ulcers, osteoporosis (direct inhibition of osteoblasts) myopathy, cataracts

Resource summary

	Created by Zulhilmi Zainal about 10 years ago