Mak Sch
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Biologie Quiz on Neurodeg2, created by Mak Sch on 30/11/2017.

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Question 1 of 11

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Question 1. Infection-like process related to assembled Aβ, tau and α-synuclein has the following characteristics

Select one of the following:

  • A. Protein misfolding begins in specific regions

  • B. Pathological assemblies of misfolded protein spread to other areas

  • C. Prion-like process

  • D. All of the above

Explanation

Question 2 of 11

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Question 2. The following are the main risk factors for cognitive decline and dementia, except:

Select one of the following:

  • A. Traumatic brain injury

  • B. Obesity and diabetes

  • C. Hypertension

  • D. Education

Explanation

Question 3 of 11

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Question 3. In some individuals at early stages of Alzheimer disease
there is a:

Select one of the following:

  • A. Severe loss of parietal cortical neurons

  • B. Severe loss of entorihnal cortex neurons

  • C. Severe loss of occipital cortical neurons

  • D. Severe loss of all cortical neurons

Explanation

Question 4 of 11

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Question 4. The author of this lecture proposes a glial hypothesis of the origin of normal aging. This hypothesis says that:

Select one of the following:

  • A. Synaptic atrophy is driven by astrocyte activation

  • B. Increase of transcription of GFAP

  • C. Age impairment of neurite growth reversed
    by SiRNA diminishing GFAP in old astrocytes

  • D. All of the above

Explanation

Question 5 of 11

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Question 5. Age and Alzheimer changes in amyloidosis and neurodegeneration are related to the presence of the number of copies of a cholesterol transporter :

Select one of the following:

  • ApoE4

  • PS1

  • APP

  • PS2

Explanation

Question 6 of 11

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Recent research proposes that aging cortical atrophy is most probably due to:

Select one or more of the following:

  • A. Loss of a huge number of small neurons

  • B. Neuron schrinkage

  • C. Loss of large neurons

  • D. Astrocyte loss

Explanation

Question 7 of 11

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Question 7. Supported by strong evidence we recognize now as main factors to decrease risk of cognitive decline and dementia:
(more than one answer possible)

Select one or more of the following:

  • B. Education

  • C. Being vegetarian

  • D. Physical activity

  • A. Moderate Alcohol consumption

Explanation

Question 8 of 11

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Question 8. Normal aging includes the decline of all these processes, except:

Select one of the following:

  • A. Eye-blinking conditioning

  • B. EEG response time auditory response to auditory stimulus

  • C. Axonal conduction speed

  • D. Verbal memory

Explanation

Question 9 of 11

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Question 9. During normal aging in the cerebral cortex:

Select one of the following:

  • A. Decrease the numbers of astrocytes

  • B. Decrease the numbers of entorhinal cells

  • C. Increase the number of astrocytes

  • D. Increase the number of olygodendrocytes

Explanation

Question 10 of 11

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Question 10. Normal aging of the brain includes:
(more than one answer possible)

Select one or more of the following:

  • A. Atrophy of cerebral cortex

  • B. Fast loss of cognitive of processes

  • C. Loss of synapses

  • D. Accumulation of amyloid

Explanation

Question 11 of 11

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Question 11. Which of the following Alzheimer related genes are not involved in familiar early onset of the disease:

Select one or more of the following:

  • D. Chromosome 21 APP gene

  • C. Chromosome 19 ApoE gene

  • B. Chromosome 14 PS-1 gene

  • A. Chromosome 1 PS-2 gene

Explanation

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