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Question 1
Question
Question 1. Infection-like process related to assembled Aβ, tau and α-synuclein has the following characteristics
Answer
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A. Protein misfolding begins in specific regions
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B. Pathological assemblies of misfolded protein spread to other areas
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C. Prion-like process
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D. All of the above
Question 2
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Question 2. The following are the main risk factors for cognitive decline and dementia, except:
Answer
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A. Traumatic brain injury
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B. Obesity and diabetes
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C. Hypertension
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D. Education
Question 3
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Question 3. In some individuals at early stages of Alzheimer disease
there is a:
Answer
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A. Severe loss of parietal cortical neurons
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B. Severe loss of entorihnal cortex neurons
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C. Severe loss of occipital cortical neurons
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D. Severe loss of all cortical neurons
Question 4
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Question 4. The author of this lecture proposes a glial hypothesis of the origin of normal aging. This hypothesis says that:
Answer
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A. Synaptic atrophy is driven by astrocyte activation
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B. Increase of transcription of GFAP
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C. Age impairment of neurite growth reversed by SiRNA diminishing GFAP in old astrocytes
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D. All of the above
Question 5
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Question 5. Age and Alzheimer changes in amyloidosis and neurodegeneration are related to the presence of the number of copies of a cholesterol transporter :
Answer
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ApoE4
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PS1
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APP
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PS2
Question 6
Question
Recent research proposes that aging cortical atrophy is most probably due to:
Answer
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A. Loss of a huge number of small neurons
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B. Neuron schrinkage
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C. Loss of large neurons
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D. Astrocyte loss
Question 7
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Question 7. Supported by strong evidence we recognize now as main factors to decrease risk of cognitive decline and dementia:
(more than one answer possible)
Answer
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B. Education
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C. Being vegetarian
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D. Physical activity
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A. Moderate Alcohol consumption
Question 8
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Question 8. Normal aging includes the decline of all these processes, except:
Answer
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A. Eye-blinking conditioning
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B. EEG response time auditory response to auditory stimulus
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C. Axonal conduction speed
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D. Verbal memory
Question 9
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Question 9. During normal aging in the cerebral cortex:
Answer
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A. Decrease the numbers of astrocytes
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B. Decrease the numbers of entorhinal cells
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C. Increase the number of astrocytes
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D. Increase the number of olygodendrocytes
Question 10
Question
Question 10. Normal aging of the brain includes:
(more than one answer possible)
Answer
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A. Atrophy of cerebral cortex
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B. Fast loss of cognitive of processes
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C. Loss of synapses
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D. Accumulation of amyloid
Question 11
Question
Question 11. Which of the following Alzheimer related genes are not involved in familiar early onset of the disease:
Answer
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D. Chromosome 21 APP gene
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C. Chromosome 19 ApoE gene
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B. Chromosome 14 PS-1 gene
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A. Chromosome 1 PS-2 gene
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