Mak Sch
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Biologie Quiz on Neurodeg3AD, created by Mak Sch on 30/11/2017.

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Neurodeg3AD

Question 1 of 12

1

Cognitive features impaired in AD are:

Select one of the following:

  • Attentional and executive deficits

  • Anterograde episodic memory

  • Semantics

  • All of the above

Explanation

Question 2 of 12

1

Question 2
Working memory is:
(multiple answers are possible)

Select one or more of the following:

  • A. a cognitive system that is responsible for the transient holding, processing, and manipulation of information

  • B. an executive controller that interacts with separate short-term stores for auditory-verbal and visuo-spatial information

  • C. a cognitive system where information can be stored for long periods of time

  • D. a limited capacity system that is capable of briefly storing and manage information involved in the performance of complex cognitive tasks such as reasoning, comprehension and certain types of learning

Explanation

Question 3 of 12

1

Synaptic loss is a prominent early pathological feature of AD, and closely associated to cognitive decline, it is mainly localized:
Answers:

Select one of the following:

  • A. Hippocampus

  • B. Diffuse in all the brain

  • C. Mainly in Cortices

  • D. Entorhinal cortex

Explanation

Question 4 of 12

1

Described by Braak and Braak, tangles sequentially appear in the following specific regions as AD progresses:

Select one or more of the following:

  • A. Limbic-Isocortical-Transentorihnal

  • B. Transetorihnal-Limbic-Isocortical

  • C. Isocortical-Transentorihnal- Limbic

  • D. Transentorihnal- Isocortical-Limbic

Explanation

Question 5 of 12

1

In Anterograde Amnesia: (multiple answers possible)
Answers:


Select one or more of the following:

  • A. Memories created prior to the event that caused the amnesia are lost while new memories can still be created.

  • B. There is loss of the ability to create new memories after the event that caused the amnesia, leading to a partial or complete inability to recall the recent past

  • C. New memories can still be created.

  • D. Long-term memories from before the event remain intact

Explanation

Question 6 of 12

1

Question 6
One of the earliest pathological changes on AD is the increase in tangle Tau formation in:

Select one of the following:

  • A. Transenthorhinal region

  • B. Striatum

  • D. Parietal cortex

  • C. Prefrontal cortex

Explanation

Question 7 of 12

1

The most common familial early onset AD is related to:



Select one or more of the following:

  • A. Presenilin 2 gene at Chromosome 1

  • B. Apolipoprotein E gene at Chromosome 19

  • C. Presenilin 1 gene at Chromosome 14

  • D. Amyloid protein precursor at Chromosome 21

Explanation

Question 8 of 12

1

Question 8
Studies of AD patients with FDG-PET + MRI coregistration (Positron emission tomography with fluoro-2-deoxy-D-glucose in combination to Magnetic Resonance Imaging) revealed the importance of the following structures in the site of early pathology in AD
(multiple answers possible)

Select one or more of the following:

  • A. Posterior cingulate

  • D. Mediotemporal lobe

  • C. Mammillary bodies and thalamus,

  • B. Retrosplenial cortex

Explanation

Question 9 of 12

1

Question 9
Other early pathological changes on AD is the increase in amyloid plaques in:
(multiple answer possible)

Select one or more of the following:

  • A. Transenthorhinal region

  • D. Parietal cortex

  • B. Posterior cinguate cortex

  • C. Frontal and association cortices

Explanation

Question 10 of 12

1

Question 10
The greatest risk factors for Alzheimer's are: (multiple answers possible)

Select one or more of the following:

  • A. Gender

  • B. Age

  • C. Genetics

  • D. Head injury

Explanation

Question 11 of 12

1

Hallmarks of Alzheimer's include: (multiple answer possible)

Select one or more of the following:

  • A. Degeneration of hippocampal and cortical neurons

  • B. Reduced cholinergic transmission

  • C. Neuritic plaques

  • D. Neurofibrillary Tangles

Explanation

Question 12 of 12

1

The following are the aims of AD treatment active and possible at the present time:
(multiple answers possible)

Select one or more of the following:

  • A. Neuroregeneration (reversal of symptomatic decline)

  • B. Augmentation (delay of symptomatic decline)

  • C. Neuroprotection (slowing of symptomatic decline)

  • D. Suppression (inhibition of symptomatic decline)

Explanation

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