Matthew Coulson
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Perinatal adaptions I lecture given on the monday morning of week 5

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Matthew Coulson
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Perinatal Adaptions Lecture I

Question 1 of 33

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In neonates, the patent blood vessel that shunts blood from the pulmonary artery to the aorta is known as the

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Question 2 of 33

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At what point in gestation do the alveoli develop?
( 36 weeks, 30 weeks, 34 weeks ) gestation

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Question 3 of 33

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Later in the pregnancy, the amniotic fluid is mostly made up of which fluid produced by the foetus?
Foetal

Explanation

Question 4 of 33

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Which organ(s), which allow processing of amniotic fluid when swallowed by the foetus, plays an important role in amniotic fluid recycling?

Select one of the following:

  • The kidneys

  • The liver

  • The stomach

  • The pancreas

Explanation

Question 5 of 33

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Which maternal antibody is passed from mother to baby via the placenta?

Select one of the following:

  • IgG

  • IgA

  • IgE

  • IgD

Explanation

Question 6 of 33

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The ductus venosus allows bypassing of which organ by the foetal blood before birth?
The

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Question 7 of 33

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The foramen ovale, which closes after birth, causes a ( right to left, left to right ) shunting of blood whilst the foetus is still inside the uterus

Explanation

Question 8 of 33

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No blood whatsoever is transported to the lungs in the growing foetus

Select one of the following:

  • True
  • False

Explanation

Question 9 of 33

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In adults, the remnant of the ductus venosus is called the of the liver

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Question 10 of 33

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In adults, the remnant of the ductus arteriosus is known as the

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Question 11 of 33

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Unlike anywhere else in the body, ( oxygen, nitrogen, carbon dioxide ) acts as a vasoconstrictor in the ductus arteriosus thus contributing towards its closure following birth.
( A reduction, An increase ) in the level of prostaglandins in the blood also contributes towards ductus arteriosus closure following birth

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Question 12 of 33

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Oxygen typically acts as a ( vasodilator, vasoconstrictor ) in the body's blood vessels

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Question 13 of 33

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The foramen in the foetal heart allowing right to left shunting of blood via the atria is called the foramen

Explanation

Question 14 of 33

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Which form of fat is produced in excess by the foetus in the final stages of pregnancy in order to facilitate thermogeneration upon entrance to the world?

Select one of the following:

  • White fat

  • Brown fat

Explanation

Question 15 of 33

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Fat Types:
= Good for energy storage
= Good for quick breakdown and energy release (e.g. thermogeneration)

Select option below to complete the highlighted text

    Brown fat
    White fat

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Question 16 of 33

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The fat pad that typically generates between the scapulae of the foetus in late pregnancy typically consists of which type of fat?
( Brown, White ) fat

Explanation

Question 17 of 33

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One of the main worries for the baby during late pregnancy/labour/birth is the development of hypoxia. Hypoxia in a foetus would likely lead to ...

Select one of the following:

  • Metabolic acidosis

  • Metabolic alkalosis

  • Respiratory acidosis

  • Respiratory alkalosis

Explanation

Question 18 of 33

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Persistence of the foetal circulation (patent foramen ovale/ductus arteriosus/etc) can lead to the pulmonary vessels not opening properly thus causing persistent pulmonary ( hypertension, hypotension ) of the newborn (PPHN)

Explanation

Question 19 of 33

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Persistent Pulmonary Hypertension of the Newborn is investigated by measuring the oxygen saturations of the hands and feet.
In a case of PPHN:
The ( hands, feet ) will have a near normal O2 saturation
The ( feet, hands ) will have an abnormal O2 saturation

Explanation

Question 20 of 33

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Management of PPHN is via multiple processes, one of which is ventilation using oxygen and which other vasodilating molecule?

Explanation

Question 21 of 33

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Inotropes such as ( adrenaline, oxytocin, oxygen, magnesium sulphate ) are also given in order to raise the ( systemic, pulmonary ) blood pressure above the ( pulmonary, systemic ) pressure thus allowing the blood to force itself into the pulmonary circulation, hopefully solving the problem.

Explanation

Question 22 of 33

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Transient occurs in infants when there is insufficient clearing of fluid from the foetal lungs

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Question 23 of 33

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Neonates typically do not shiver in order to produce heat. Preterm neonates are therefore more likely to become hypothermic due to a lower content of ( brown fat, white fat, glycogen )

Explanation

Question 24 of 33

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The dark green substance forming the first faeces of a newborn infant is called the

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Question 25 of 33

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When something touches a neonate's mouth, it instinctively opens it's mouth and tries to latch onto it. What is this reflex called?
The reflex

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Question 26 of 33

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Noramly breastfeeding should involve the neonate's tongue pushing the nipple against the ( soft, hard ) palate in order to facilitate lactation

Explanation

Question 27 of 33

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Foetal blood is ( more, less ) concentrated in haemoglobin than adult blood

Explanation

Question 28 of 33

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For which of the following reasons does Foetal Haemoglobin have a higher affinity for oxygen?

Select one of the following:

  • It does not interact with 2,3-DPG

  • It does interact with 2,3-DPG

  • It does not respond to changes in temperature

  • It does respond to changes in temperature

  • It does not respond to changes in CO2 content of the foetal blood

  • It does respond to changes in CO2 content of the foetal blood

Explanation

Question 29 of 33

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Foetal haemoglobin is produced in the
Adult haemoglobin is produced in the

Explanation

Question 30 of 33

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Newborns can typically become anaemic as the foetal haemoglobin is broken down faster than the adult haemoglobin can be produced to replace it

Select one of the following:

  • True
  • False

Explanation

Question 31 of 33

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Haemoglobin breakdown yields which substance?

Explanation

Question 32 of 33

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Accumulation of bilirubin in the foetal circulation causes neonatal

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Question 33 of 33

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Foetal jaundice is a case of accumulation of ( unconjugated, conjugated ) bilirubin

Explanation