Breast Pathology II

Question 1 of 37

1

Breast Carcinoma is considered to be which type of carcinoma?

Select one of the following:

Adenocarcinoma
Basal cell carcinoma
Squamous cell carcinoma
Transitional cell carcinoma

Explanation

Question 2 of 37

1

Breast Adenocarcinoma commonly occurs in the epithelial cells of which breast structure?

Select one of the following:

Terminal Duct Lobular Units
Lactiferous Ducts
Areola
Lactiferous Sinus
Breast Vascular Tissues

Explanation

Question 3 of 37

1

Fill the blank spaces to complete the text.

A carcinoma which hasn't yet breached basement membrane is known as an carcinoma
A carcinoma which has breached the basement membrane is known as an carcinoma

Explanation

Question 4 of 37

1

Lobular neoplasias:
❌ = >50% of lobule involved
❌ = <50% of lobule involved
❌ = Typically >50% of lobule involved & breach of basement membrane

Drag and drop to complete the text.

Invasive Carcinoma

Atypical Lobular Hyperplasia

Lobular Carcinoma in situ

Atypical Lobular Hypertrophy

Explanation

Question 5 of 37

1

Fill the blank space to complete the text.

Lobular neoplasms typically grow in response to which hormone?

Explanation

Question 6 of 37

1

The red dots show tumours in a breast. Which shows a multifocal cancer and which shows a multicentric cancer?

Drag an answer into the correct orange point.

multifocal

multicentric

Explanation

Question 7 of 37

1

Select from the dropdown lists to complete the text.

Description of a Lobular In Situ Neoplasia:
Frequently ( multifocal, multicentric, unifocal ) and ( bilateral, unilateral )
Incidence ( decreases, increases ) following menopause
( Is not, Is ) typically palpable
Usually ( incidental, non-incidental ) finding

Explanation

Question 8 of 37

1

How are lobular neoplasms typically managed?

Select one of the following:

Excision following diagnosis
Reassurance and watchful waiting

Explanation

Question 9 of 37

1

A woman has a routine mammography scan conducted as part of the breast screening program. Three small lesions are noticed in the upper outer quadrant of her right breast. If you were to suggest a biopsy of these lesions, which 2 of the following might you consider?

Select one or more of the following:

Core Needle Biopsy
Vacuum Needle Biopsy
Fine Needle Aspiration
Immediate Surgical Excision of Lesions

Explanation

Question 10 of 37

1

In which breast structures do Ductal Carcinoma In Situ originate?

Select one of the following:

Terminal Duct Lobular Unit
Lactiferous Duct
Lactiferous Sinus
Sub-areolar structures
Breast Vasculature

Explanation

Question 11 of 37

1

Ductal carcinoma in situ is typically ❌

Drag and drop to complete the text.

unicentric (affects single duct system)

multicentric (multiple duct systems)

Explanation

Question 12 of 37

1

❌ = Confined within the basement membrane of the duct
❌ = Breached the basement membrane of the duct

Drag and drop to complete the text.

Invasive Ductal Carcinoma

Ductal Carcinoma in situ

Explanation

Question 13 of 37

1

Fill the blank space to complete the text.

Observe the picture. Which condition are you worried about in this woman?
of the breast

Explanation

Question 14 of 37

1

Select from the dropdown list to complete the text.

Paget's Disease of the Breast is typically indicative of an underlying ( Ductal Carcinoma In Situ, Invasive Ductal Carcinoma )

Explanation

Question 15 of 37

1

Which of the following are typical signs of Paget's Disease of the Breast?

Select one or more of the following:

Involuted nipple
Straw-coloured/bloody discharge from nipple
Burning pain sensation in nipple
Eczema on the nipple
Low hanging breast on affected side

Explanation

Question 16 of 37

1

Fill the blank space to complete the text.

In the case of high grade ductal neoplasms such as DCIS, growth of the tumour can outpace the development of the blood supply thus leading to the entire duct becoming plugged with cancerous cells which typically become necrosed. This is known as necrosis.

Explanation

Question 17 of 37

1

How is Ductal Carcinoma In Situ typically managed?

Select one of the following:

Surgical excision +/- radiotherapy
Reassurance & watchful waiting
Core Needle/Vacuum Biopsy to exclude invasive carcinoma then radiotherapy only

Explanation

Question 18 of 37

1

Fill the blank space to complete the text.

Which structure is breached in invasive carcinomas?
The

Explanation

Question 19 of 37

1

Breast cancer is the most commonly diagnosed cancer in females

Select one of the following:

True
False

Explanation

Question 20 of 37

1

Fill the blank space to complete the text.

Which cancer most commonly affects males?
cancer

Explanation

Question 21 of 37

1

Having a child which a woman subsequently breast feeds significantly reduces her risk of developing breast cancer at a later age.

Select one of the following:

True
False

Explanation

Question 22 of 37

1

Nulliparous women are less likely to develop breast cancer

Select one of the following:

True
False

Explanation

Question 23 of 37

1

Select from the dropdown lists to complete the text.

Risk Factors for Breast Cancer Development:
( Early, Late ) menarche
( Late, Early ) menopause

Explanation

Question 24 of 37

1

Hormone therapies such as HRT and the Oral Contraceptive Pill have negligible effects on the risk of breast cancer development

Select one of the following:

True
False

Explanation

Question 25 of 37

1

Women in Western Europe have the highest incidence of breast cancer of any geographical region in the world.

Select one of the following:

True
False

Explanation

Question 26 of 37

1

Which of the following has a greater impact on the risk of breast cancer development?

Select one of the following:

Cigarette Smoking
High Alcohol Consumption

Explanation

Question 27 of 37

1

Select from the dropdown list to complete the text.

Which genetic mutations are the most common indicators of breast cancer risk in women?
( BRCA, BCRF, BCAG ) mutations 1 and 2

Explanation

Question 28 of 37

1

Select from the dropdown list to complete the text.

Statistically, 1 in every ( 8, 6, 12, 20 ) women will develop breast cancer at some point in their lifetime.

Explanation

Question 29 of 37

1

Which of the following is the most common invasive breast carcinoma?

Select one of the following:

Ductal
Lobular
Tubular
Mucinous
Medullary

Explanation

Question 30 of 37

1

Which of the following is the second most common invasive breast carcinoma?

Select one of the following:

Ductal
Lobular
Mucinous
Tubular
Medullary

Explanation

Question 31 of 37

1

Which lymph nodes do breast carcinomas typically metastasize to?

Select one of the following:

Axillary
Para-aortic
Abdominal
Internal Mammary
Supraclavicular

Explanation

Question 32 of 37

1

Fill the blank space to complete the text.

The lymph node is the hypothetical first lymph node or group of nodes in which a tumour drains.

Explanation

Question 33 of 37

1

The more hormone receptors an invasive carcinoma has, the better its prognosis.

Select one of the following:

True
False

Explanation

Question 34 of 37

1

In terms of hormone receptors, 80% of invasive breast carcinomas are positive for ❌ receptors and 67% are positive for ❌ receptors

Drag and drop to complete the text.

progesterone

oestrogen

Explanation

Question 35 of 37

1

Fill the blank space to complete the text.

is an anti-oestrogen prodrug which when given gives rise to compounds which act as oestrogen receptor antagonists, thus preventing the growth and proliferation of cancer cells.

Explanation

Question 36 of 37

1

Tamoxifen should not be given to those with non-invasive breast cancer (e.g. DCIS)

Select one of the following:

True
False

Explanation

Question 37 of 37

1

The primary treatment for invasive breast cancers such as Invasive Ductal Carcinoma is hormone adjuvant therapy

Select one of the following:

True
False

	Created by Matthew Coulson over 5 years ago

Breast apthology II lecture given on the morning of tuesday 8th January

Breast Pathology II

Question 1 of 37

Breast Carcinoma is considered to be which type of carcinoma?

Select one of the following:

Explanation

Question 2 of 37

Breast Adenocarcinoma commonly occurs in the epithelial cells of which breast structure?

Select one of the following:

Explanation

Question 3 of 37

Fill the blank spaces to complete the text.

A carcinoma which hasn't yet breached basement membrane is known as an carcinoma A carcinoma which has breached the basement membrane is known as an carcinoma

Explanation

Question 4 of 37

Lobular neoplasias: ❌ = >50% of lobule involved ❌ = <50% of lobule involved ❌ = Typically >50% of lobule involved & breach of basement membrane

Drag and drop to complete the text.

Explanation

Question 5 of 37

Fill the blank space to complete the text.

Lobular neoplasms typically grow in response to which hormone?

Explanation

Question 6 of 37

The red dots show tumours in a breast. Which shows a multifocal cancer and which shows a multicentric cancer?

Drag an answer into the correct orange point.

Explanation

Question 7 of 37

Select from the dropdown lists to complete the text.

Explanation

Question 8 of 37

How are lobular neoplasms typically managed?

Select one of the following:

Explanation

Question 9 of 37

A woman has a routine mammography scan conducted as part of the breast screening program. Three small lesions are noticed in the upper outer quadrant of her right breast. If you were to suggest a biopsy of these lesions, which 2 of the following might you consider?

Select one or more of the following:

Explanation

Question 10 of 37

In which breast structures do Ductal Carcinoma In Situ originate?

Select one of the following:

Explanation

Question 11 of 37

Ductal carcinoma in situ is typically ❌

Drag and drop to complete the text.

Explanation

Question 12 of 37

❌ = Confined within the basement membrane of the duct ❌ = Breached the basement membrane of the duct

Drag and drop to complete the text.

Explanation

Question 13 of 37

Fill the blank space to complete the text.

Observe the picture. Which condition are you worried about in this woman? of the breast

Explanation

Question 14 of 37

Select from the dropdown list to complete the text.

Paget's Disease of the Breast is typically indicative of an underlying Ductal Carcinoma In Situ Invasive Ductal Carcinoma( Ductal Carcinoma In Situ, Invasive Ductal Carcinoma )

Explanation

Question 15 of 37

Which of the following are typical signs of Paget's Disease of the Breast?

Select one or more of the following:

Explanation

Question 16 of 37

Fill the blank space to complete the text.

In the case of high grade ductal neoplasms such as DCIS, growth of the tumour can outpace the development of the blood supply thus leading to the entire duct becoming plugged with cancerous cells which typically become necrosed. This is known as necrosis.

Explanation

Question 17 of 37

How is Ductal Carcinoma In Situ typically managed?

Select one of the following:

Explanation

Question 18 of 37

Fill the blank space to complete the text.

Which structure is breached in invasive carcinomas? The

Explanation

Question 19 of 37

Breast cancer is the most commonly diagnosed cancer in females

Select one of the following:

Explanation

Question 20 of 37

Fill the blank space to complete the text.

Which cancer most commonly affects males? cancer

A carcinoma which hasn't yet breached basement membrane is known as an carcinoma
A carcinoma which has breached the basement membrane is known as an carcinoma

Lobular neoplasias:
❌ = >50% of lobule involved
❌ = <50% of lobule involved
❌ = Typically >50% of lobule involved & breach of basement membrane

❌ = Confined within the basement membrane of the duct
❌ = Breached the basement membrane of the duct

Observe the picture. Which condition are you worried about in this woman?
of the breast

Paget's Disease of the Breast is typically indicative of an underlying ( Ductal Carcinoma In Situ, Invasive Ductal Carcinoma )

Which structure is breached in invasive carcinomas?
The

Which cancer most commonly affects males?
cancer

Risk Factors for Breast Cancer Development:
( Early, Late ) menarche
( Late, Early ) menopause

Which genetic mutations are the most common indicators of breast cancer risk in women?
( BRCA, BCRF, BCAG ) mutations 1 and 2

Statistically, 1 in every ( 8, 6, 12, 20 ) women will develop breast cancer at some point in their lifetime.