Matthew Coulson
Quiz by , created more than 1 year ago

Multiple Myeloma, AL Amyloidosis, MGUS and Waldenstrom's Macroglobulinaemia

7
1
0
Matthew Coulson
Created by Matthew Coulson about 5 years ago
Close

Myeloma and Other Plasma Cell Disorders

Question 1 of 28

1

Select from the dropdown lists to complete the text.

Immunoglobulins are antibodies produced by B cells/Plasma cells that are made up of ( 2, 1, 3 ) heavy chains and ( 2, 1, 3 ) light chains

Explanation

Question 2 of 28

1

Which of the immunoglobulins has a pentameric structure?

Select one of the following:

  • IgM

  • IgG

  • IgA

Explanation

Question 3 of 28

1

Which of the immunoglobulins has a dimeric structure?

Select one of the following:

  • IgM

  • IgA

  • IgG

Explanation

Question 4 of 28

1

Which of the immunoglobulins have monomeric structures?

Select one or more of the following:

  • IgM

  • IgG

  • IgA

  • IgE

  • IgD

Explanation

Question 5 of 28

1

Fill the blank space to complete the text.

cells have an eccentric 'clock face nucleus' on H&E Stain

Explanation

Question 6 of 28

1

Select from the dropdown list to complete the text.

Plasma cells are characterised by their ( open, closed ) chromatin

Explanation

Question 7 of 28

1

Fill the blank space to complete the text.

Monoclonal immunoglobulins are all derived from clonal expansion of one single B cell. Monoclonal immunoglobulins are also known as

Explanation

Question 8 of 28

1

Select from the dropdown list to complete the text.

Paraproteins = ( Monoclonal, Polyclonal ) Immunoglobulins

Explanation

Question 9 of 28

1

Paraproteins are a marker of an underlying clonal B cell disorder

Select one of the following:

  • True
  • False

Explanation

Question 10 of 28

1

What is the best form of investigation for detecting Paraproteins

Select one of the following:

  • Immunophenotyping by Flow Cytometry

  • Serum Electrophoresis

  • Fluorescence In-Situ Hybridisation

  • Cell Morphology

Explanation

Question 11 of 28

1

Select from the dropdown list to complete the text.

Paraproteins found on Serum Electrophoresis tend to present in the ( Gamma, Beta, Albumin, Alpha-1, Alpha-2 ) band

Explanation

Question 12 of 28

1

Fill the blank space to complete the text.

After serum electrophoresis has been conducted to detect paraproteins, serum should then be conducted in order to classify the abnormal protein band

Explanation

Question 13 of 28

1

Select from the dropdown list to complete the text.

Bence Jones Protein is a monoclonal immunoglobulin light chain which is detected by ( urine, serum, bone marrow, CSF ) electrophoresis

Explanation

Question 14 of 28

1

The presence of Bence Jones Protein in the urine is suggestive of which two of the following conditions?

Select one or more of the following:

  • Multiple Myeloma

  • Waldenström's Macroglobulinemia

  • Monoclonal Gammopathy of Undetermined Significance (MGUS)

  • Alpha heavy chain disease

  • Acute Lymphoblastic Leukaemia

Explanation

Question 15 of 28

1

Which of the following is most common condition causative of paraproteinaemia?

Select one of the following:

  • Multiple Myeloma

  • Monoclonal gammopathy of undetermined significance (MGUS)

  • Waldenstrom's Macroglobulinemia

Explanation

Question 16 of 28

1

Monoclonal gammopathy of undetermined significance (MGUS) is a benign (premalignant) condition which can predispose to Multiple Myeloma

Select one of the following:

  • True
  • False

Explanation

Question 17 of 28

1

Select from the dropdown lists to complete the text.

Myeloma causes ( renal, liver, heart ) failure and increased ( bone breakdown, blood pressure, erythrocytosis, sodium levels )

Explanation

Question 18 of 28

1

Myeloma is classified based on which type of monoclonal antibody is produced. What is the most common type of Myeloma?

Select one of the following:

  • IgG Myeloma

  • IgE Myeloma

  • IgA Myeloma

  • IgD Myeloma

  • IgM Myeloma

Explanation

Question 19 of 28

1

Select from the dropdown list to complete the text.

Due to bone breakdown occurring as part of Myeloma, it also typically causes raised ( Calcium, Sodium, Potassium, Phosphate ) levels in the blood

Explanation

Question 20 of 28

1

Fill the blank space to complete the text.

The paraproteins in Myeloma bring about renal failure by blocking the renal

Explanation

Question 21 of 28

1

Fill the blank space to complete the text.

Paraproteins blocking the renal tubules as part of Myeloma forms small aggregations leading to what is known as nephropathy

Explanation

Question 22 of 28

1

Select from the dropdown list to complete the text.

Myeloma tends to affect those in their ( 60s, 40s, 20s, teens )

Explanation

Question 23 of 28

1

Fill the blank space to complete the text.

Levels of in the blood should be monitored in order to monitor the response of a Myeloma patient to Chemotherapy.

Explanation

Question 24 of 28

1

Which of the following should be avoided in Myeloma patients?

Select one of the following:

  • NSAIDs

  • Amoxicillin

  • Antipsychotics

  • Antiemetics

  • Paracetamol

Explanation

Question 25 of 28

1

Fill the blank space to complete the text.

Which drug type should be given to myeloma patients in order to correct their hypercalcaemia and reduce their bone pain?

Explanation

Question 26 of 28

1

Select from the dropdown lists to complete the text.

Monoclonal gammopathy of undetermined significance (MGUS) can be diagnosed when there is a paraprotein level of ( <30g/l, <20g/l, <50g/l, <60g/l ) and a bone marrow plasma cell level of ( <10%, <20%, <30%, <40%, <50% ). There must also be no evidence of any end organ damage (e.g. renal failure, bone marrow failure, etc)

Explanation

Question 27 of 28

1

Fill the blank space to complete the text.

A plasma cell immunoglobulin disorder is suspected in a patient. When a sample from the patient was stained using Congo Red and placed under polarising light it showed an 'apple-green' birefringence. What condition is the patient suffering from?

Explanation

Question 28 of 28

1

Select from the dropdown list to complete the text.

Waldenstrom’s macroglobulinaemia is a condition which characteristically involves ( IgM, IgG, IgA, IgE, IgD ) Paraproteins

Explanation

Previous
Next