Leishmania control innate immune response: Sandfly commensal bacteria promote Leishmania human infection

Sandfly gut microbes prime host cell inflammasome
- Sand flies have commensal bacterial in their saliva/gut, transmit bacteria with saliva + promastigote secretory gel, activate inflammasome-> draws out immune cells (neutrophil infiltration)
- Inflammasome derived IL-1β keeps neutrophils at bite sites
Antibiotics:
- Treating sandfly with antibiotics before transmission blocks neutrophil infiltration- Antibiotic clears the commensal bacteria
- Impairs Leishmania dissemination (parasite transmission without inflammation- lower level of transmission)

	Created by Chloe Cavarretta over 7 years ago

Immunology L19

10. Pathogens vs Immune System