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Created by Leanne van den Berg
over 4 years ago
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What are these intrachromosomal abberations called?
what is the difference between intrachromosomal and inter chromosomal abberations?
What is the difference between a balanced and an unbalanced translocation?
Which 3 steps are required for gene fusions?
Name 3 reasons for gene fusions
What are 3 consequences of oncogenic chromosomal translocations
Which 3 methods can be used to detect translocations and fusions?
Can FISH be done on FFPE or only of FF material
What is the difference between a break apart FISH and a fusion FISH
What chromosomal abberations can be seen with FISH?
Why would you used RNA seq instead of DNA seq (NGS/ Sanger)?
For translocation detection: When do you use RNA seq, and when FISH
How does Archer RNA seq work?
Name 2 pros and 2 cons of Archer
What is Nanostring used for?
Name 2 pros and 2 cons of Nanostring
Name 2 pros and 2 cons of RNA sequencing
What markers are used for the detection of B and T cells in IHC?
BCR rearrangement involves combinations of different fragments. Which fragments are combined in the light and which in the heavy chain
On which region of the BCR gene do primers bind to detect clonality for B cell malignancies?
What are the pitfalls of gene rearrangement analysis using TCR/BCR?
What is the difference between lymphomas and leukemia?
What 3 molecular things are testen in lymphomas
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