Woody Payne
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Subcategory of Circadian Endocrinology

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Woody Payne
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Melatonin

Question 1 of 9

1

Melatonin exerts its effects by:

Select one or more of the following:

  • Acting as an ultradian hormone.

  • Acting as an antioxidant.

  • Acting upon melatonin receptors.

  • Acting upon adrenergic receptors.

  • Acting to protect mitochondrial and nuclear DNA.

Explanation

Question 2 of 9

1

Melatonin is produced by which of the following pathways.

Substances:
1.Serotonin
2.Melatonin
3.L-Tryptophan
4.N-Acetyl Serotonin
5.5-HTP

Enzymes:
A.tryptophan 5-hydroxylase
B.acetylserotonin O-methyltransferase
C.AANAT
D.5-HTP decarboxylase

Select one of the following:

  • 1B4D2A3C5

  • 3A5D1C4B2

  • 3A1C5D4B2

  • 1B4D3C2A5

Explanation

Question 3 of 9

1

Bioavailability and Half-Life of Melatonin

Select one of the following:

  • 30-50% and 30-50 Minutes.

  • 40-60% and 20 to 30 Minutes.

  • 15-25% and 60 to 90 Minutes.

  • 60-80% and 90 to 120 Minutes.

Explanation

Question 4 of 9

1

Melatonin is regulated by Norepinephrine by which pathway:

Substance:
1.Norepinephrine

Enzyme:
A.PKA
B.AANAT

Receptor:
a.Beta Adrenergic

Select one of the following:

  • 1aBA

  • Ba1A

  • AB1a

  • 1aAB

Explanation

Question 5 of 9

1

Light of which of the following wavelength criteria will not inhibit melatonin

Select one of the following:

  • Under 530 nm.

  • Over 480 nm.

  • Over 530 nm.

  • Under 480 nm.

Explanation

Question 6 of 9

1

Dopamine plays a role in Melatonin secretion by:

Select one of the following:

  • Providing negative feedback to Melatonin formation.

  • Upregulating Melatonin receptors.

  • Enhancing the effects of Norepinephrine on Melatonin secretion.

  • Increasing in response to Melatonin binding with receptors.

Explanation

Question 7 of 9

1

5HT has which of the following functions and changes:

Select one or more of the following:

  • It decreases Serotonin production.

  • It is decreased by AANAT to be converted to Melatonin.

  • It is produced only during the day.

  • Its production leads to increased sympathetic activity and receptor activation on the pineal gland, ultimately leading to decreased Melatonin synthesis.

  • Dopamine activation of the D4 receptor heteromeres decreases 5HT in the morning.

Explanation

Question 8 of 9

1

The Pineal Gland is located outside of the blood brain barrier.

Select one of the following:

  • True
  • False

Explanation

Question 9 of 9

1

Melatonin affects the following hormones by:

Select one or more of the following:

  • Increasing LH.

  • Decreasing FSH.

  • Decreasing Leptin.

  • Increasing Prolactin and Cytokines.

  • Decreasing Corticosterone.

Explanation

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