Jess Pope
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Antibiotics MCQs

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Jess Pope
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Antibiotics MCQs

Question 1 of 81

1

Bactericidal drugs kill bacteria.

Select one of the following:

  • True
  • False

Explanation

Question 2 of 81

1

Which class of drugs slows bacterial growth?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

Explanation

Question 3 of 81

1

When a bacteriostatic drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?

Select one of the following:

  • Increase

  • Decrease

  • Stay the same

Explanation

Question 4 of 81

1

When a bactericidal drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?

Select one of the following:

  • Increase

  • Decrease

  • Stay the same

Explanation

Question 5 of 81

1

When a bacteriostatic drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?

Select one of the following:

  • Increase

  • Decrease

  • Stay the same

Explanation

Question 6 of 81

1

When a bactericidal drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?

Select one of the following:

  • Increase

  • Decrease

  • Stay the same

Explanation

Question 7 of 81

1

Are the actions of sulphonamides bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 8 of 81

1

Is the action of trimethaprim bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 9 of 81

1

Are the actions of tetracyclines bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 10 of 81

1

Is the action of chloramphenicol bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 11 of 81

1

Is the action of linomycin bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 12 of 81

1

Is the action of erythromycin (macrolides) bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 13 of 81

1

Are the actions of penicillins bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 14 of 81

1

Are the actions of cephalosporins bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 15 of 81

1

Are the actions of fluoroquinolones bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 16 of 81

1

Are the actions of aminoglycosides bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 17 of 81

1

Is the action of metronidazole bactericidal or bacteriostatic?

Select one of the following:

  • Bactericidal

  • Bacteriostatic

  • Concentration dependent

Explanation

Question 18 of 81

1

A potentiated sulphonamide refers to which of the following combinations of antibacterial agents?

Select one of the following:

  • Sulphonamide and Erythromycin

  • Sulphonamide and Fluoroquinolone

  • Sulphonamide and Trimethoprim

  • Sulphonamide and Chloramphenicol

  • Sulphonamide and Cephalosporin

Explanation

Question 19 of 81

1

What is the main aim for optimum efficacy of a time dependent drug?

Select one of the following:

  • Plasma levels should be above minimum inhibitory concentration (MIC) for as long as possible in each 24 hour period

  • Plasma levels should be as high as possible for as long as possible

  • The dosage is irrelevant, but the drug must be in the system for as long as possible

Explanation

Question 20 of 81

1

Which of the following drugs is time dependent?

Select one of the following:

  • Aminoglycoside

  • Penicillin

  • Fluoroquinolones

  • Metronidazole

Explanation

Question 21 of 81

1

Which of the following drugs is time dependent?

Select one of the following:

  • Aminoglycoside

  • Cephalosporin

  • Fluoroquinolone

  • Metronidazole

Explanation

Question 22 of 81

1

Which of the following drugs are concentration dependent?

Select one or more of the following:

  • Penicillin

  • Aminoglycoside

  • Metronidasole

  • Cephalosporin

  • Fluoroquinolone

Explanation

Question 23 of 81

1

Where are NAMA and NAG synthesised?

Select one of the following:

  • Cytoplasm

  • Membrane

  • Extra-membrane

Explanation

Question 24 of 81

1

How many peptides are initially attached to NAMA?

Select one of the following:

  • 3

  • 4

  • 5

  • 6

Explanation

Question 25 of 81

1

What is the most important feature for the activity of a penicillin/cephalosporin?

Select one of the following:

  • Ring of 2 carbons and 2 nitrogens

  • Ring of 3 carbons and 1 nitrogen

  • Ring of 5 carbons

  • Ring of 5 carbons and 1 nitrogen

  • Ring of 4 carbons and 2 nitrogens

Explanation

Question 26 of 81

1

What determines the antibacterial activity of β-lactams?

Select one of the following:

  • R side chain

  • Ability to bind to peptidyl transferase

  • Ability to bind to transpeptidases

  • Drug size

  • Ability to bind to gamma-glutamyl transpeptidase

Explanation

Question 27 of 81

1

The ability for penicillin to access transpeptidase is limited in gram +ve bacteria.

Select one of the following:

  • True
  • False

Explanation

Question 28 of 81

1

Clavulanic acid has an antibacterial effect when administered alone.

Select one of the following:

  • True
  • False

Explanation

Question 29 of 81

1

Which of the following drugs would be best paired with clavulanic acid?

Select one of the following:

  • Mecillinam

  • Cloxacillin

  • Benzylpenicillin

  • Methicillin

  • Amoxicillin

Explanation

Question 30 of 81

1

Benzylpenicillin has good acid stability.

Select one of the following:

  • True
  • False

Explanation

Question 31 of 81

1

Which of the following drugs are susceptible to β-lactamase activity?

Select one or more of the following:

  • Benzylpenicillin

  • Penicillin V

  • Cloxacillin

  • Methicillin

  • Ampicillin

  • Amoxicillin

  • Carbenicillin

  • Mecillinam

Explanation

Question 32 of 81

1

Which of the following drugs are not susceptible to β-lactamase activity?

Select one or more of the following:

  • Cloxacillin

  • Benzylpenicillin

  • Methicillin

  • Mecillinam

  • Carbenicillin

Explanation

Question 33 of 81

1

Which of the following drugs are most effective against Gram +ve cocci?

Select one or more of the following:

  • Benzylpenicillin

  • Mecillinam

  • Penicillin V

  • Cloxacillin

  • Methicillin

Explanation

Question 34 of 81

1

Which of the following drugs is most active against Gram -ve bacteria?

Select one of the following:

  • Mecillinam

  • Methicillin

  • Cloxacillin

  • Carbenicillin

Explanation

Question 35 of 81

1

Which of the following drugs is efficacious against pseudomonas?

Select one of the following:

  • Mecillinam

  • Cloxacillin

  • Carbenicillin

  • Methicillin

Explanation

Question 36 of 81

1

Which generations of cephalosporins are unstable in acid?

Select one or more of the following:

  • 1st generation

  • 2nd generation

  • 3rd generation

  • 4th generation

Explanation

Question 37 of 81

1

Which generation of cephalosporin has the least β-lactamase stability?

Select one of the following:

  • 1st generation

  • 2nd generation

  • 3rd generation

  • 4th generation

Explanation

Question 38 of 81

1

Which generations of cephalosporin are least susceptible to β-lactamase activity?

Select one or more of the following:

  • 1st generation

  • 2nd generation

  • 3rd generation

  • 4th generation

Explanation

Question 39 of 81

1

Which of the following drugs is most efficacious against gram +ve bacteria?

Select one of the following:

  • Cephalexin

  • Cefuroxime

  • Cefovecin

  • Cefquinome

Explanation

Question 40 of 81

1

Which of the following drugs is most efficacious against gram -ve bacteria?

Select one of the following:

  • Cephradine

  • Cephalexin

  • Cefquinome

  • Cefovecin

Explanation

Question 41 of 81

1

Which of the following drugs is efficacious against pseudomonas?

Select one of the following:

  • Cephradine

  • Cefovecin

  • Cefquinome

  • Cefuroxime

Explanation

Question 42 of 81

1

Penicillins and cephalosporins are eliminated by the liver.

Select one of the following:

  • True
  • False

Explanation

Question 43 of 81

1

Penicillins do not cross the BBB, despite being widely distributed.

Select one of the following:

  • True
  • False

Explanation

Question 44 of 81

1

Some cephalosporins cross the BBB.

Select one of the following:

  • True
  • False

Explanation

Question 45 of 81

1

Aminoglycosides induce a long lasting mutation in bacteria, so are risky to use given that resistance may easily occur.

Select one of the following:

  • True
  • False

Explanation

Question 46 of 81

1

What type of bacteria are aminoglycosides more efficacious against?

Select one of the following:

  • Gram -ve anaerobic bacteria

  • Gram -ve aerobic bacteria

  • Gram +ve anaerobic bacteria

  • Gram +ve aerobic bacteria

Explanation

Question 47 of 81

1

Aminoglycosides are typically bactericidal.

Select one of the following:

  • True
  • False

Explanation

Question 48 of 81

1

Aminoglycosides have poor oral bioavailability.

Select one of the following:

  • True
  • False

Explanation

Question 49 of 81

1

How are aminoglycosides eliminated from the body?

Select one of the following:

  • Liver metabolism

  • Renal excretion

  • Excreted in bile

  • Metabolism in muscles

Explanation

Question 50 of 81

1

How do macrocodes inhibit bacteria protein synthesis?

Select one of the following:

  • Bind to ‘A’ site, prevent initiation

  • Bind to ‘P’ site, prevent translocation

  • Bind to ‘E’ site, prevent translocation

  • Bind to ‘A’ site, prevent termination

Explanation

Question 51 of 81

1

What type of bacteria are macrocodes more efficacious against?

Select one of the following:

  • Gram -ve

  • Gram +ve

Explanation

Question 52 of 81

1

Macrocodes have poor oral bioavailability.

Select one of the following:

  • True
  • False

Explanation

Question 53 of 81

1

How are macrolides eliminated from he body?

Select one of the following:

  • Metabolised by liver

  • Renal excretion

  • Excreted in bile

  • Metabolism in muscles

Explanation

Question 54 of 81

1

At doses normally used in veterinary practice, erythromycin is bactericidal.

Select one of the following:

  • True
  • False

Explanation

Question 55 of 81

1

How do lincosamides inhibit bacteria protein synthesis?

Select one of the following:

  • Bind to 'A' site, prevent initiation

  • Bind to 'P' site, prevent elongation

  • Bind to 'E' site, prevent elongation

  • Bind to 'E' site, prevent termination

Explanation

Question 56 of 81

1

How do tetracyclines inhibit bacterial protein synthesis?

Select one of the following:

  • Bind to 'A' site, prevent initiation

  • Bind to 'P' site, prevent elongation

  • Bind to 'E' site, prevent elongation

  • Bind to 'E' site, prevent termination

Explanation

Question 57 of 81

1

Which class of bacteria are tetracyclines most effective against?

Select one of the following:

  • Gram +ve aerobes

  • Gram +ve anaerobes

  • Gram -ve aerobes

  • Gram -ve anaerobes

  • Wide spectrum against aerobic and anaerobic Gram +ve and –ve bacteria

Explanation

Question 58 of 81

1

Tetracyclines have a bacteriostatic effect.

Select one of the following:

  • True
  • False

Explanation

Question 59 of 81

1

How are tetracyclines eliminated from the body?

Select one or more of the following:

  • Metabolism by the liver

  • Renal excretion

  • Excreted in bile

  • Metabolism by muscles

Explanation

Question 60 of 81

1

Tetracyclines inhibit mammalian protein synthesis. Why are the side effects not more severe than those observed if this is the case?

Select one of the following:

  • The drug is delivered directly to the site of action, minimising the systematic effect

  • The concentration is not high enough to affect mammalian cells

  • Mammalian cells do not efficiently transport tetracyclines across cell membrane

  • Tetracyclines on affect cells with a cell wall

Explanation

Question 61 of 81

1

How does chloramphenicol inhibit bacterial protein synthesis?

Select one of the following:

  • Binds to 'A' site, inhibits initiation

  • Binds to 'P' site, inhibits elongation

  • Inhibits peptide bond formation

  • Binds to 'E' site, inhibits termination

Explanation

Question 62 of 81

1

Chloramphenicol is banned in food-producing animals

Select one of the following:

  • True
  • False

Explanation

Question 63 of 81

1

Chloramphenicol had poor oral bioavailability.

Select one of the following:

  • True
  • False

Explanation

Question 64 of 81

1

Chloramphenicol can cross the BBB.

Select one of the following:

  • True
  • False

Explanation

Question 65 of 81

1

Chloramphenicol has a bacteriocidal effect.

Select one of the following:

  • True
  • False

Explanation

Question 66 of 81

1

How is chloramphenicol eliminated from the body?

Select one of the following:

  • Liver metabolism

  • Renal excretion

  • Excreted in bile

  • Metabolised in muscles

Explanation

Question 67 of 81

1

In which class of bacteria is chloramphenicol most efficacious?

Select one of the following:

  • Gram positive aerobes

  • Gram negative aerobes

  • Obligate anaerobes

  • Penicillinase producing - Staphylococcus

Explanation

Question 68 of 81

1

Which of the following drugs affect folate synthesis?

Select one or more of the following:

  • Cyclosporins

  • Chloramphenicol

  • Sulphonamides

  • Tetracycline

  • Trimethoprim

Explanation

Question 69 of 81

1

Which class of bacteria are sulphonamides most efficacious against?

Select one of the following:

  • Gram -ve anaerobes

  • Gram - aerobes

  • Gram +ve anaerobes

  • Gram +ve aerobes

  • Wide spectrum against Gram +ve and –ve bacteria

Explanation

Question 70 of 81

1

Sulphonamides have poor oral bioavailability.

Select one of the following:

  • True
  • False

Explanation

Question 71 of 81

1

Sulphonamides can cross the BBB.

Select one of the following:

  • True
  • False

Explanation

Question 72 of 81

1

How are sulphonamides excreted from the body?

Select one of the following:

  • Metabolised by the liver

  • Renal excretion

  • Excreted in bile

  • Metabolised by muscles

Explanation

Question 73 of 81

1

Sulphonamides have a bacteriostatic effect.

Select one of the following:

  • True
  • False

Explanation

Question 74 of 81

1

How does trimethoprim affect bacterial folate synthesis?

Select one of the following:

  • Inhibits uptake of p-aminobenzoic acid (PABA)

  • Inhibits dihydropteroate synthetase (DHPS)

  • Inhibits dihydropteroate reductase (DHPR)

  • Inhibits dihydrofolate synthetase (DHFS)

  • Inhibits dihydrofolate reductase (DHFR)

Explanation

Question 75 of 81

1

How are fluoroquinolones eliminated form the body?

Select one or more of the following:

  • Metabolised by liver

  • Renal excretion

  • Excreted in bile

  • Metabolised by muscles

Explanation

Question 76 of 81

1

Fluoroquinolones have poor oral bioavailability

Select one of the following:

  • True
  • False

Explanation

Question 77 of 81

1

Fluoroquinolones have a bactericidal effect.

Select one of the following:

  • True
  • False

Explanation

Question 78 of 81

1

Which class of bacteria is metronidazole most efficacious against?

Select one of the following:

  • Gram positive aerobes

  • Gram negative aerobes

  • Obligate anaerobes

  • Penicillinase producing Staphylococcus

Explanation

Question 79 of 81

1

Metronidazole has good oral bioavailability

Select one of the following:

  • True
  • False

Explanation

Question 80 of 81

1

Metronidazole can cross the BBB.

Select one of the following:

  • True
  • False

Explanation

Question 81 of 81

1

How is metronidazole eliminated from the body?

Select one or more of the following:

  • Metabolised by the liver

  • Renal excretion

  • Biliary excretion

  • Metabolised by muscles

Explanation

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