Antibiotics MCQs

1. 1Bactericidal drugs kill bacteria.

   1. ATrue
   2. BFalse
2. 2Which class of drugs slows bacterial growth?

   1. ABactericidal
   2. BBacteriostatic
3. 3When a bacteriostatic drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?

   1. AIncrease
   2. BDecrease
   3. CStay the same
4. 4When a bactericidal drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?

   1. AIncrease
   2. BDecrease
   3. CStay the same
5. 5When a bacteriostatic drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?

   1. AIncrease
   2. BDecrease
   3. CStay the same
6. 6When a bactericidal drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?

   1. AIncrease
   2. BDecrease
   3. CStay the same
7. 7Are the actions of sulphonamides bactericidal or bacteriostatic?

   1. ABactericidal
   2. BBacteriostatic
   3. CConcentration dependent
8. 8Is the action of trimethaprim bactericidal or bacteriostatic?

   1. ABactericidal
   2. BBacteriostatic
   3. CConcentration dependent
9. 9Are the actions of tetracyclines bactericidal or bacteriostatic?

   1. ABactericidal
   2. BBacteriostatic
   3. CConcentration dependent
10. 10Is the action of chloramphenicol bactericidal or bacteriostatic?

    1. ABactericidal
    2. BBacteriostatic
    3. CConcentration dependent

11. 11Is the action of linomycin bactericidal or bacteriostatic?

    1. ABactericidal
    2. BBacteriostatic
    3. CConcentration dependent
12. 12Is the action of erythromycin (macrolides) bactericidal or bacteriostatic?

    1. ABactericidal
    2. BBacteriostatic
    3. CConcentration dependent
13. 13Are the actions of penicillins bactericidal or bacteriostatic?

    1. ABactericidal
    2. BBacteriostatic
    3. CConcentration dependent
14. 14Are the actions of cephalosporins bactericidal or bacteriostatic?

    1. ABactericidal
    2. BBacteriostatic
    3. CConcentration dependent
15. 15Are the actions of fluoroquinolones bactericidal or bacteriostatic?

    1. ABactericidal
    2. BBacteriostatic
    3. CConcentration dependent
16. 16Are the actions of aminoglycosides bactericidal or bacteriostatic?

    1. ABactericidal
    2. BBacteriostatic
    3. CConcentration dependent
17. 17Is the action of metronidazole bactericidal or bacteriostatic?

    1. ABactericidal
    2. BBacteriostatic
    3. CConcentration dependent
18. 18A potentiated sulphonamide refers to which of the following combinations of antibacterial agents?

    1. ASulphonamide and Erythromycin
    2. BSulphonamide and Fluoroquinolone
    3. CSulphonamide and Trimethoprim
    4. DSulphonamide and Chloramphenicol
    5. ESulphonamide and Cephalosporin
19. 19What is the main aim for optimum efficacy of a time dependent drug?

    1. APlasma levels should be above minimum inhibitory concentration (MIC) for as long as possible in each 24 hour period
    2. BPlasma levels should be as high as possible for as long as possible
    3. CThe dosage is irrelevant, but the drug must be in the system for as long as possible
20. 20Which of the following drugs is time dependent?

    1. AAminoglycoside
    2. BPenicillin
    3. CFluoroquinolones
    4. DMetronidazole
21. 21Which of the following drugs is time dependent?

    1. AAminoglycoside
    2. BCephalosporin
    3. CFluoroquinolone
    4. DMetronidazole
22. 22Which of the following drugs are concentration dependent?

    1. APenicillin
    2. BAminoglycoside
    3. CMetronidasole
    4. DCephalosporin
    5. EFluoroquinolone
23. 23Where are NAMA and NAG synthesised?

    1. ACytoplasm
    2. BMembrane
    3. CExtra-membrane
24. 24How many peptides are initially attached to NAMA?

    1. A3
    2. B4
    3. C5
    4. D6
25. 25What is the most important feature for the activity of a penicillin/cephalosporin?

    1. ARing of 2 carbons and 2 nitrogens
    2. BRing of 3 carbons and 1 nitrogen
    3. CRing of 5 carbons
    4. DRing of 5 carbons and 1 nitrogen
    5. ERing of 4 carbons and 2 nitrogens
26. 26What determines the antibacterial activity of β-lactams?

    1. AR side chain
    2. BAbility to bind to peptidyl transferase
    3. CAbility to bind to transpeptidases
    4. DDrug size
    5. EAbility to bind to gamma-glutamyl transpeptidase
27. 27The ability for penicillin to access transpeptidase is limited in gram +ve bacteria.

    1. ATrue
    2. BFalse
28. 28Clavulanic acid has an antibacterial effect when administered alone.

    1. ATrue
    2. BFalse
29. 29Which of the following drugs would be best paired with clavulanic acid?

    1. AMecillinam
    2. BCloxacillin
    3. CBenzylpenicillin
    4. DMethicillin
    5. EAmoxicillin
30. 30Benzylpenicillin has good acid stability.

    1. ATrue
    2. BFalse
31. 31Which of the following drugs are susceptible to β-lactamase activity?

    1. ABenzylpenicillin
    2. BPenicillin V
    3. CCloxacillin
    4. DMethicillin
    5. EAmpicillin
    6. FAmoxicillin
    7. GCarbenicillin
    8. HMecillinam
32. 32Which of the following drugs are not susceptible to β-lactamase activity?

    1. ACloxacillin
    2. BBenzylpenicillin
    3. CMethicillin
    4. DMecillinam
    5. ECarbenicillin
33. 33Which of the following drugs are most effective against Gram +ve cocci?

    1. ABenzylpenicillin
    2. BMecillinam
    3. CPenicillin V
    4. DCloxacillin
    5. EMethicillin
34. 34Which of the following drugs is most active against Gram -ve bacteria?

    1. AMecillinam
    2. BMethicillin
    3. CCloxacillin
    4. DCarbenicillin
35. 35Which of the following drugs is efficacious against pseudomonas?

    1. AMecillinam
    2. BCloxacillin
    3. CCarbenicillin
    4. DMethicillin
36. 36Which generations of cephalosporins are unstable in acid?

    1. A1st generation
    2. B2nd generation
    3. C3rd generation
    4. D4th generation
37. 37Which generation of cephalosporin has the least β-lactamase stability?

    1. A1st generation
    2. B2nd generation
    3. C3rd generation
    4. D4th generation
38. 38Which generations of cephalosporin are least susceptible to β-lactamase activity?

    1. A1st generation
    2. B2nd generation
    3. C3rd generation
    4. D4th generation
39. 39Which of the following drugs is most efficacious against gram +ve bacteria?

    1. ACephalexin
    2. BCefuroxime
    3. CCefovecin
    4. DCefquinome
40. 40Which of the following drugs is most efficacious against gram -ve bacteria?

    1. ACephradine
    2. BCephalexin
    3. CCefquinome
    4. DCefovecin
41. 41Which of the following drugs is efficacious against pseudomonas?

    1. ACephradine
    2. BCefovecin
    3. CCefquinome
    4. DCefuroxime
42. 42Penicillins and cephalosporins are eliminated by the liver.

    1. ATrue
    2. BFalse
43. 43Penicillins do not cross the BBB, despite being widely distributed.

    1. ATrue
    2. BFalse
44. 44Some cephalosporins cross the BBB.

    1. ATrue
    2. BFalse
45. 45Aminoglycosides induce a long lasting mutation in bacteria, so are risky to use given that resistance may easily occur.

    1. ATrue
    2. BFalse
46. 46What type of bacteria are aminoglycosides more efficacious against?

    1. AGram -ve anaerobic bacteria
    2. BGram -ve aerobic bacteria
    3. CGram +ve anaerobic bacteria
    4. DGram +ve aerobic bacteria
47. 47Aminoglycosides are typically bactericidal.

    1. ATrue
    2. BFalse
48. 48Aminoglycosides have poor oral bioavailability.

    1. ATrue
    2. BFalse
49. 49How are aminoglycosides eliminated from the body?

    1. ALiver metabolism
    2. BRenal excretion
    3. CExcreted in bile
    4. DMetabolism in muscles
50. 50How do macrocodes inhibit bacteria protein synthesis?

    1. ABind to ‘A’ site, prevent initiation
    2. BBind to ‘P’ site, prevent translocation
    3. CBind to ‘E’ site, prevent translocation
    4. DBind to ‘A’ site, prevent termination
51. 51What type of bacteria are macrocodes more efficacious against?

    1. AGram -ve
    2. BGram +ve
52. 52Macrocodes have poor oral bioavailability.

    1. ATrue
    2. BFalse
53. 53How are macrolides eliminated from he body?

    1. AMetabolised by liver
    2. BRenal excretion
    3. CExcreted in bile
    4. DMetabolism in muscles
54. 54At doses normally used in veterinary practice, erythromycin is bactericidal.

    1. ATrue
    2. BFalse
55. 55How do lincosamides inhibit bacteria protein synthesis?

    1. ABind to 'A' site, prevent initiation
    2. BBind to 'P' site, prevent elongation
    3. CBind to 'E' site, prevent elongation
    4. DBind to 'E' site, prevent termination
56. 56How do tetracyclines inhibit bacterial protein synthesis?

    1. ABind to 'A' site, prevent initiation
    2. BBind to 'P' site, prevent elongation
    3. CBind to 'E' site, prevent elongation
    4. DBind to 'E' site, prevent termination
57. 57Which class of bacteria are tetracyclines most effective against?

    1. AGram +ve aerobes
    2. BGram +ve anaerobes
    3. CGram -ve aerobes
    4. DGram -ve anaerobes
    5. EWide spectrum against aerobic and anaerobic Gram +ve and –ve bacteria
58. 58Tetracyclines have a bacteriostatic effect.

    1. ATrue
    2. BFalse
59. 59How are tetracyclines eliminated from the body?

    1. AMetabolism by the liver
    2. BRenal excretion
    3. CExcreted in bile
    4. DMetabolism by muscles
60. 60Tetracyclines inhibit mammalian protein synthesis. Why are the side effects not more severe than those observed if this is the case?

    1. AThe drug is delivered directly to the site of action, minimising the systematic effect
    2. BThe concentration is not high enough to affect mammalian cells
    3. CMammalian cells do not efficiently transport tetracyclines across cell membrane
    4. DTetracyclines on affect cells with a cell wall
61. 61How does chloramphenicol inhibit bacterial protein synthesis?

    1. ABinds to 'A' site, inhibits initiation
    2. BBinds to 'P' site, inhibits elongation
    3. CInhibits peptide bond formation
    4. DBinds to 'E' site, inhibits termination
62. 62Chloramphenicol is banned in food-producing animals

    1. ATrue
    2. BFalse
63. 63Chloramphenicol had poor oral bioavailability.

    1. ATrue
    2. BFalse
64. 64Chloramphenicol can cross the BBB.

    1. ATrue
    2. BFalse
65. 65Chloramphenicol has a bacteriocidal effect.

    1. ATrue
    2. BFalse
66. 66How is chloramphenicol eliminated from the body?

    1. ALiver metabolism
    2. BRenal excretion
    3. CExcreted in bile
    4. DMetabolised in muscles
67. 67In which class of bacteria is chloramphenicol most efficacious?

    1. AGram positive aerobes
    2. BGram negative aerobes
    3. CObligate anaerobes
    4. DPenicillinase producing - Staphylococcus
68. 68Which of the following drugs affect folate synthesis?

    1. ACyclosporins
    2. BChloramphenicol
    3. CSulphonamides
    4. DTetracycline
    5. ETrimethoprim
69. 69Which class of bacteria are sulphonamides most efficacious against?

    1. AGram -ve anaerobes
    2. BGram - aerobes
    3. CGram +ve anaerobes
    4. DGram +ve aerobes
    5. EWide spectrum against Gram +ve and –ve bacteria
70. 70Sulphonamides have poor oral bioavailability.

    1. ATrue
    2. BFalse
71. 71Sulphonamides can cross the BBB.

    1. ATrue
    2. BFalse
72. 72How are sulphonamides excreted from the body?

    1. AMetabolised by the liver
    2. BRenal excretion
    3. CExcreted in bile
    4. DMetabolised by muscles
73. 73Sulphonamides have a bacteriostatic effect.

    1. ATrue
    2. BFalse
74. 74How does trimethoprim affect bacterial folate synthesis?

    1. AInhibits uptake of p-aminobenzoic acid (PABA)
    2. BInhibits dihydropteroate synthetase (DHPS)
    3. CInhibits dihydropteroate reductase (DHPR)
    4. DInhibits dihydrofolate synthetase (DHFS)
    5. EInhibits dihydrofolate reductase (DHFR)
75. 75How are fluoroquinolones eliminated form the body?

    1. AMetabolised by liver
    2. BRenal excretion
    3. CExcreted in bile
    4. DMetabolised by muscles
76. 76Fluoroquinolones have poor oral bioavailability

    1. ATrue
    2. BFalse
77. 77Fluoroquinolones have a bactericidal effect.

    1. ATrue
    2. BFalse
78. 78Which class of bacteria is metronidazole most efficacious against?

    1. AGram positive aerobes
    2. BGram negative aerobes
    3. CObligate anaerobes
    4. DPenicillinase producing Staphylococcus
79. 79Metronidazole has good oral bioavailability

    1. ATrue
    2. BFalse
80. 80Metronidazole can cross the BBB.

    1. ATrue
    2. BFalse
81. 81How is metronidazole eliminated from the body?

    1. AMetabolised by the liver
    2. BRenal excretion
    3. CBiliary excretion
    4. DMetabolised by muscles

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Antibiotics MCQs

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