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Antibiotics MCQs

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Antibiotics MCQs
Jess Pope
Quiz by Jess Pope, updated more than 1 year ago
Jess Pope
Created by Jess Pope over 7 years ago
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Question 1

Question
Bactericidal drugs kill bacteria.
Answer
  • True
  • False

Question 2

Question
Which class of drugs slows bacterial growth?
Answer
  • Bactericidal
  • Bacteriostatic

Question 3

Question
When a bacteriostatic drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?
Answer
  • Increase
  • Decrease
  • Stay the same

Question 4

Question
When a bactericidal drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?
Answer
  • Increase
  • Decrease
  • Stay the same

Question 5

Question
When a bacteriostatic drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?
Answer
  • Increase
  • Decrease
  • Stay the same

Question 6

Question
When a bactericidal drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?
Answer
  • Increase
  • Decrease
  • Stay the same

Question 7

Question
Are the actions of sulphonamides bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 8

Question
Is the action of trimethaprim bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 9

Question
Are the actions of tetracyclines bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 10

Question
Is the action of chloramphenicol bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 11

Question
Is the action of linomycin bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 12

Question
Is the action of erythromycin (macrolides) bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 13

Question
Are the actions of penicillins bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 14

Question
Are the actions of cephalosporins bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 15

Question
Are the actions of fluoroquinolones bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 16

Question
Are the actions of aminoglycosides bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 17

Question
Is the action of metronidazole bactericidal or bacteriostatic?
Answer
  • Bactericidal
  • Bacteriostatic
  • Concentration dependent

Question 18

Question
A potentiated sulphonamide refers to which of the following combinations of antibacterial agents?
Answer
  • Sulphonamide and Erythromycin
  • Sulphonamide and Fluoroquinolone
  • Sulphonamide and Trimethoprim
  • Sulphonamide and Chloramphenicol
  • Sulphonamide and Cephalosporin

Question 19

Question
What is the main aim for optimum efficacy of a time dependent drug?
Answer
  • Plasma levels should be above minimum inhibitory concentration (MIC) for as long as possible in each 24 hour period
  • Plasma levels should be as high as possible for as long as possible
  • The dosage is irrelevant, but the drug must be in the system for as long as possible

Question 20

Question
Which of the following drugs is time dependent?
Answer
  • Aminoglycoside
  • Penicillin
  • Fluoroquinolones
  • Metronidazole

Question 21

Question
Which of the following drugs is time dependent?
Answer
  • Aminoglycoside
  • Cephalosporin
  • Fluoroquinolone
  • Metronidazole

Question 22

Question
Which of the following drugs are concentration dependent?
Answer
  • Penicillin
  • Aminoglycoside
  • Metronidasole
  • Cephalosporin
  • Fluoroquinolone

Question 23

Question
Where are NAMA and NAG synthesised?
Answer
  • Cytoplasm
  • Membrane
  • Extra-membrane

Question 24

Question
How many peptides are initially attached to NAMA?
Answer
  • 3
  • 4
  • 5
  • 6

Question 25

Question
What is the most important feature for the activity of a penicillin/cephalosporin?
Answer
  • Ring of 2 carbons and 2 nitrogens
  • Ring of 3 carbons and 1 nitrogen
  • Ring of 5 carbons
  • Ring of 5 carbons and 1 nitrogen
  • Ring of 4 carbons and 2 nitrogens

Question 26

Question
What determines the antibacterial activity of β-lactams?
Answer
  • R side chain
  • Ability to bind to peptidyl transferase
  • Ability to bind to transpeptidases
  • Drug size
  • Ability to bind to gamma-glutamyl transpeptidase

Question 27

Question
The ability for penicillin to access transpeptidase is limited in gram +ve bacteria.
Answer
  • True
  • False

Question 28

Question
Clavulanic acid has an antibacterial effect when administered alone.
Answer
  • True
  • False

Question 29

Question
Which of the following drugs would be best paired with clavulanic acid?
Answer
  • Mecillinam
  • Cloxacillin
  • Benzylpenicillin
  • Methicillin
  • Amoxicillin

Question 30

Question
Benzylpenicillin has good acid stability.
Answer
  • True
  • False

Question 31

Question
Which of the following drugs are susceptible to β-lactamase activity?
Answer
  • Benzylpenicillin
  • Penicillin V
  • Cloxacillin
  • Methicillin
  • Ampicillin
  • Amoxicillin
  • Carbenicillin
  • Mecillinam

Question 32

Question
Which of the following drugs are not susceptible to β-lactamase activity?
Answer
  • Cloxacillin
  • Benzylpenicillin
  • Methicillin
  • Mecillinam
  • Carbenicillin

Question 33

Question
Which of the following drugs are most effective against Gram +ve cocci?
Answer
  • Benzylpenicillin
  • Mecillinam
  • Penicillin V
  • Cloxacillin
  • Methicillin

Question 34

Question
Which of the following drugs is most active against Gram -ve bacteria?
Answer
  • Mecillinam
  • Methicillin
  • Cloxacillin
  • Carbenicillin

Question 35

Question
Which of the following drugs is efficacious against pseudomonas?
Answer
  • Mecillinam
  • Cloxacillin
  • Carbenicillin
  • Methicillin

Question 36

Question
Which generations of cephalosporins are unstable in acid?
Answer
  • 1st generation
  • 2nd generation
  • 3rd generation
  • 4th generation

Question 37

Question
Which generation of cephalosporin has the least β-lactamase stability?
Answer
  • 1st generation
  • 2nd generation
  • 3rd generation
  • 4th generation

Question 38

Question
Which generations of cephalosporin are least susceptible to β-lactamase activity?
Answer
  • 1st generation
  • 2nd generation
  • 3rd generation
  • 4th generation

Question 39

Question
Which of the following drugs is most efficacious against gram +ve bacteria?
Answer
  • Cephalexin
  • Cefuroxime
  • Cefovecin
  • Cefquinome

Question 40

Question
Which of the following drugs is most efficacious against gram -ve bacteria?
Answer
  • Cephradine
  • Cephalexin
  • Cefquinome
  • Cefovecin

Question 41

Question
Which of the following drugs is efficacious against pseudomonas?
Answer
  • Cephradine
  • Cefovecin
  • Cefquinome
  • Cefuroxime

Question 42

Question
Penicillins and cephalosporins are eliminated by the liver.
Answer
  • True
  • False

Question 43

Question
Penicillins do not cross the BBB, despite being widely distributed.
Answer
  • True
  • False

Question 44

Question
Some cephalosporins cross the BBB.
Answer
  • True
  • False

Question 45

Question
Aminoglycosides induce a long lasting mutation in bacteria, so are risky to use given that resistance may easily occur.
Answer
  • True
  • False

Question 46

Question
What type of bacteria are aminoglycosides more efficacious against?
Answer
  • Gram -ve anaerobic bacteria
  • Gram -ve aerobic bacteria
  • Gram +ve anaerobic bacteria
  • Gram +ve aerobic bacteria

Question 47

Question
Aminoglycosides are typically bactericidal.
Answer
  • True
  • False

Question 48

Question
Aminoglycosides have poor oral bioavailability.
Answer
  • True
  • False

Question 49

Question
How are aminoglycosides eliminated from the body?
Answer
  • Liver metabolism
  • Renal excretion
  • Excreted in bile
  • Metabolism in muscles

Question 50

Question
How do macrocodes inhibit bacteria protein synthesis?
Answer
  • Bind to ‘A’ site, prevent initiation
  • Bind to ‘P’ site, prevent translocation
  • Bind to ‘E’ site, prevent translocation
  • Bind to ‘A’ site, prevent termination

Question 51

Question
What type of bacteria are macrocodes more efficacious against?
Answer
  • Gram -ve
  • Gram +ve

Question 52

Question
Macrocodes have poor oral bioavailability.
Answer
  • True
  • False

Question 53

Question
How are macrolides eliminated from he body?
Answer
  • Metabolised by liver
  • Renal excretion
  • Excreted in bile
  • Metabolism in muscles

Question 54

Question
At doses normally used in veterinary practice, erythromycin is bactericidal.
Answer
  • True
  • False

Question 55

Question
How do lincosamides inhibit bacteria protein synthesis?
Answer
  • Bind to 'A' site, prevent initiation
  • Bind to 'P' site, prevent elongation
  • Bind to 'E' site, prevent elongation
  • Bind to 'E' site, prevent termination

Question 56

Question
How do tetracyclines inhibit bacterial protein synthesis?
Answer
  • Bind to 'A' site, prevent initiation
  • Bind to 'P' site, prevent elongation
  • Bind to 'E' site, prevent elongation
  • Bind to 'E' site, prevent termination

Question 57

Question
Which class of bacteria are tetracyclines most effective against?
Answer
  • Gram +ve aerobes
  • Gram +ve anaerobes
  • Gram -ve aerobes
  • Gram -ve anaerobes
  • Wide spectrum against aerobic and anaerobic Gram +ve and –ve bacteria

Question 58

Question
Tetracyclines have a bacteriostatic effect.
Answer
  • True
  • False

Question 59

Question
How are tetracyclines eliminated from the body?
Answer
  • Metabolism by the liver
  • Renal excretion
  • Excreted in bile
  • Metabolism by muscles

Question 60

Question
Tetracyclines inhibit mammalian protein synthesis. Why are the side effects not more severe than those observed if this is the case?
Answer
  • The drug is delivered directly to the site of action, minimising the systematic effect
  • The concentration is not high enough to affect mammalian cells
  • Mammalian cells do not efficiently transport tetracyclines across cell membrane
  • Tetracyclines on affect cells with a cell wall

Question 61

Question
How does chloramphenicol inhibit bacterial protein synthesis?
Answer
  • Binds to 'A' site, inhibits initiation
  • Binds to 'P' site, inhibits elongation
  • Inhibits peptide bond formation
  • Binds to 'E' site, inhibits termination

Question 62

Question
Chloramphenicol is banned in food-producing animals
Answer
  • True
  • False

Question 63

Question
Chloramphenicol had poor oral bioavailability.
Answer
  • True
  • False

Question 64

Question
Chloramphenicol can cross the BBB.
Answer
  • True
  • False

Question 65

Question
Chloramphenicol has a bacteriocidal effect.
Answer
  • True
  • False

Question 66

Question
How is chloramphenicol eliminated from the body?
Answer
  • Liver metabolism
  • Renal excretion
  • Excreted in bile
  • Metabolised in muscles

Question 67

Question
In which class of bacteria is chloramphenicol most efficacious?
Answer
  • Gram positive aerobes
  • Gram negative aerobes
  • Obligate anaerobes
  • Penicillinase producing - Staphylococcus

Question 68

Question
Which of the following drugs affect folate synthesis?
Answer
  • Cyclosporins
  • Chloramphenicol
  • Sulphonamides
  • Tetracycline
  • Trimethoprim

Question 69

Question
Which class of bacteria are sulphonamides most efficacious against?
Answer
  • Gram -ve anaerobes
  • Gram - aerobes
  • Gram +ve anaerobes
  • Gram +ve aerobes
  • Wide spectrum against Gram +ve and –ve bacteria

Question 70

Question
Sulphonamides have poor oral bioavailability.
Answer
  • True
  • False

Question 71

Question
Sulphonamides can cross the BBB.
Answer
  • True
  • False

Question 72

Question
How are sulphonamides excreted from the body?
Answer
  • Metabolised by the liver
  • Renal excretion
  • Excreted in bile
  • Metabolised by muscles

Question 73

Question
Sulphonamides have a bacteriostatic effect.
Answer
  • True
  • False

Question 74

Question
How does trimethoprim affect bacterial folate synthesis?
Answer
  • Inhibits uptake of p-aminobenzoic acid (PABA)
  • Inhibits dihydropteroate synthetase (DHPS)
  • Inhibits dihydropteroate reductase (DHPR)
  • Inhibits dihydrofolate synthetase (DHFS)
  • Inhibits dihydrofolate reductase (DHFR)

Question 75

Question
How are fluoroquinolones eliminated form the body?
Answer
  • Metabolised by liver
  • Renal excretion
  • Excreted in bile
  • Metabolised by muscles

Question 76

Question
Fluoroquinolones have poor oral bioavailability
Answer
  • True
  • False

Question 77

Question
Fluoroquinolones have a bactericidal effect.
Answer
  • True
  • False

Question 78

Question
Which class of bacteria is metronidazole most efficacious against?
Answer
  • Gram positive aerobes
  • Gram negative aerobes
  • Obligate anaerobes
  • Penicillinase producing Staphylococcus

Question 79

Question
Metronidazole has good oral bioavailability
Answer
  • True
  • False

Question 80

Question
Metronidazole can cross the BBB.
Answer
  • True
  • False

Question 81

Question
How is metronidazole eliminated from the body?
Answer
  • Metabolised by the liver
  • Renal excretion
  • Biliary excretion
  • Metabolised by muscles
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