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PHSI3012 01-1 Cell Proliferation

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Preguntas del test (14)

  1. 1What is the difference between cell growth and cell proliferation?
    1. ACell growth = increase in ONE cell's mass/size; Cell proliferation = increase in cell numbers.
    2. BCell growth = increase in cell numbers; Cell proliferation = increase in ONE cell's mass/size.
    3. CNo meaningful distinction.
      (/ distinction without substantial difference)
      (/ fuck all)
  2. 2Which of the following is true?
    1. AControl of cell proliferation is intrinsically linked to cell growth.
    2. BControl of cell growth is intrinsically linked to cell proliferation.
  3. 3The order of the rough phases of the cell cycle are as follows:
    G1 > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] (then back to G1 again)
    1. AS
    2. BG2
    3. CM
    4. DCytokinesis
  4. 4G1 phase stands for, and involves, what?
    1. AGrowth phase
    2. BGap phase
    3. CCell growth
    4. DMonitoring
    5. EMitosis
  5. 5G2 phase stands for, and involves, what?
    1. AGrowth phase
    2. BGap phase
    3. CCell growth
    4. DMonitoring
    5. EMitosis
  6. 6S phase stands for, and involves, what?
    1. ADNA synthesis
    2. BSelectivity
    3. CCell growth
    4. DMitosis
    5. EStretching
  7. 7M phase stands for, and involves, what?
    1. AMitosis
    2. BMeiosis
    3. CMonitoring
    4. DDNA synthesis
    5. ECell division
  8. 8Cdks (Cyclin-Dependent KinaseS) are regulated by:
    1. ACyclins
    2. BPhosphorylation
    3. CBoth of the above
    4. D[none of the above]
  9. 9Mitogens are:
    1. AThings that stimulate cell division (e.g. hormones, cytokines).
    2. BStimulate migration.
  10. 10Disordered signaling in cancer.
    Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation.
    e.g. a mutation may lead to independence from mitogen-dependence.

    Acquiring the ability to synthesise mitogens (resulting in autocrine stimulation) is one way this can happen. Some examples of this are:
    1. APDGF, TGFα - glioblastomas & osteosarcoma
    2. BEGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)

Información

Descripción
Learning objectives: * Understand the difference between cell growth and proliferation * Describe the major events of the cell cycle * Appreciate the roles of cyclins and cyclin-dependent kinases in regulating cell cycle progression * Provide examples of disordered signaling in cancer * Describe checkpoints and how they regulate the correct expression of the cell cycle * Understand the role of apoptosis in preventing inappropriate cell proliferation
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