11679340
Descripción
Test por Nadia Persaud, actualizado hace más de 1 año
|
Creado por Nadia Persaud
hace más de 6 años
|
|
Pregunta 1
Pregunta
Which of the following is NOT indicative of accelerated red cell destruction?
Respuesta
-
decreased RBC, Hgb, Hct
-
increased unconjugated bilirubin, increased LDH
-
increase hemopexin
-
erythoid hyperplasia
-
URINE: increased urobilinogen, free hemoglobin, methemoglobin, hemosiderin
Pregunta 2
Pregunta
Which feature is present in BOTH intra- and extravascular hemolysis?
Respuesta
-
increased retics
-
spherocytes/schistocytes
-
increased unconjugated bilirubin
-
decreased poikilocytosis
-
A, B, and C
-
All of the above.
Pregunta 3
Pregunta
Select all that apply for INTRAVASCULAR hemolysis:
Respuesta
-
significant increase in LDH
-
hemoglobinemia
-
hemosiderinuria
-
IgG antibodies
-
decreased hemopexin
-
spherocytes
Pregunta 4
Pregunta
Select all that apply for EXTRAVASCULAR hemolysis:
Respuesta
-
IgG antibodies
-
presence of gall stones
-
splenomegaly
-
spherocytes
-
fragments
Pregunta 5
Pregunta
Normal adult hemoglobin consists of:
95% - 100% HbA
0% - 2% HbF
0% - 3.5% HbA2
Respuesta
- True
- False
Pregunta 6
Pregunta
Sickle Solubility screening test is a qualitative screening test that dectects the presence of sickling hemoglobins mainly HbA.
Respuesta
- True
- False
Pregunta 7
Pregunta
What are the components of an alkaline hemoglobin electrophoresis?
Respuesta
-
EDTA-borate buffer and cellulose acetate gel
-
pH 10.1
-
enzymatic reactions that move from cathode to anode
-
able to separate HbC from HbE
Pregunta 8
Pregunta
Alkaline electrophoresis runs SDG and CEOA2 together.
Respuesta
- True
- False
Pregunta 9
Pregunta
What techniques can be used to separate hemoglobin?
Respuesta
-
HbA2 ion exchange chromatography
-
HPLC: High Performance Liquid Chromatography
-
IEF: Isoelectric Focusing
-
Capillary Electrophoresis
-
Globin Chain Electrophoresis
-
All of the above
Pregunta 10
Pregunta
A positively charges cellulose attracts a negatively charged hemoglobin molecule. Which separation technique does this describe?
Respuesta
-
HPLC
-
Ion Exchange Chromatography
-
IEF
-
Globin Chain Electrophoresis
Pregunta 11
Pregunta
During HbA2 Column Chromatography, A2 is eluted as the 3mL glycine reagent and the absorbance of the A2 fraction and total hemoglobin are measured to determine the %HbA2.
Respuesta
- True
- False
Pregunta 12
Pregunta
Which hemoglobin fractions is HPLC able to detect and distinguish?
Respuesta
-
HbS
-
HbA2
-
HbF
-
HbA
-
HbC
Pregunta 13
Pregunta
Which hemoglobin separation technique separates fractions based on the difference in charge to size ratio through an electric field?
Respuesta
-
Isoelectric Focusing
-
Gas Chromatogrpahy
-
Ion Exchange Chromatography
-
Capillary Electrophoresis
-
Gel Electrophoresis
Pregunta 14
Pregunta
An increase in HbA2 is associated with which condition?
Respuesta
-
IDA
-
Beta-Thal Major
-
Alpha-Thal Minor
-
Beta-Thal Minor
-
Megaloblastic Anemia
Pregunta 15
Pregunta
The principle behind the Kleihauer-Betke Acid Elution test is eluting HbF out of the solution, making the cells colourless, while HbA are resistant to elution and will stain pink.
Respuesta
- True
- False
Pregunta 16
Pregunta
Which clinical condition is screened for using the sucrose hemolysis test?
Respuesta
-
Hereditary Persistence of Fetal Hemoglobin (HPFH)
-
Paroxymal Nocturnal Hemoglobinuria (PNH)
-
Autoimmune Hemolytic Anemia (AIHA)
-
Filariasis
Pregunta 17
Pregunta
Less than 5% hemolysis indicates that RBCs of PNH are more sensitive to complement on their cell surface.
Respuesta
- True
- False
Pregunta 18
Pregunta
HAM test for PNH is based on:
Respuesta
-
acidified serum
-
neutral serum
-
alkaline serum
Pregunta 19
Pregunta
Which of the following interpretations matches G6PD deficiency screening test?
Respuesta
-
persistant fluorescence
-
weak or no fluorescence
-
NADPH not produced
-
NAD produced
Pregunta 20
Pregunta
The amount of NAD produced is proportional to the amount of PK in patient cells
Respuesta
- True
- False
Pregunta 21
Pregunta
What stain is required to see Heinz bodies?
Respuesta
-
Gram stain
-
Wright stain
-
Supravital stain
-
Eosin stain
Pregunta 22
Pregunta
Cells that are osmotically fragile will start to lyse at:
Respuesta
-
0.85
-
0.55
-
0.45
-
0.95
Pregunta 23
Pregunta
Which of the following is not included in the major hemostatic system?
Respuesta
-
Vascular System
-
Platelet Activity
-
Coagulation System
-
Fibrinolytic System
-
Thrombin System
-
Regulatory System
Pregunta 24
Pregunta
Which of the following is an example of an anticoagulant?
Respuesta
-
VonWillebrande's Factor
-
Thromboplastin
-
Protein S
-
Tissue Plasmimnogen Factor Inhibitor
Pregunta 25
Pregunta
What is needed for platelets to adhere to the sub-endothelium?
Respuesta
-
Thrombin
-
vWF
-
Ca2+
-
Phospholipid
-
Negatively Charged Surface
Pregunta 26
Pregunta
Which of the following is true about thromboxane A2?
Respuesta
-
produced by platelets
-
causes vasoconstriction
-
induces aggregation
-
inhibited by aspirin
-
all of the above are true
Pregunta 27
Pregunta
Which platelet membrane binding site is associated with aggregation?
Respuesta
-
GPIb/IX
-
GPIIb/IIIa
-
vWF Ag
-
Collagen binding site
-
FVIII Ag
Pregunta 28
Pregunta
Which of the following is not a primary hemostasis disorder?
Respuesta
-
Bernard-Soulier Syndrome
-
von Willebrande Disease
-
Gray Platelet Syndrome
-
Glanzmann's Thrombasthenia
-
Hemophilia A
Pregunta 29
Pregunta
Reduced aggregation with Ristocetin is associated with vWD and BSS.
Respuesta
- True
- False
Pregunta 30
Pregunta
Which condition is present if a patient has vWF, but lacks the receptor site on the platelet for it?
Respuesta
-
BSS
-
Glanzmann's Thrombasthenia
-
Grey Platelet Syndrome
-
vWD
-
Storage Pool Disease
Pregunta 31
Pregunta
What is the condition called if the platelets lack the receptor fibrinogen?
Respuesta
-
BSS
-
Glanzmann's Thrombasthenia
-
Gray Platelet Syndrome
-
vWD
-
Storage Pool Disease
Pregunta 32
Pregunta
Which of the following does not contribute to clot formation?
Respuesta
-
Tissue factor
-
Calcium
-
Heparin
-
Phospholipid
-
Thrombin
Pregunta 33
Pregunta
Which of the following does thrombin not have an effect on?
Respuesta
-
FXI activation
-
FVIII activation
-
FXIII activation
-
Fibrinogen --> Fibrin
-
FVII activation
Pregunta 34
Pregunta
Which of the following factors is not Vitamin K dependent?
Respuesta
-
FII
-
FV
-
FVII
-
FIX
-
FX
Pregunta 35
Pregunta
Select all that are TRUE:
Respuesta
-
both VIII:C and VIII:Ag are deficient in hemophilia
-
FVIII is released from vWF by prothrombin
-
FVIII is labile and degrades rapidly when unbound from vWF
-
FVIII is synthesized in the liver
Pregunta 36
Pregunta
vWF is synthesized by:
Respuesta
-
the liver
-
endothelial cells
-
plasma cells
-
Vitamin K
-
bone marrow
Pregunta 37
Pregunta
vWD is associated with a deficiency in:
Respuesta
-
vWF:Rco
-
vWF:Ag
-
vWF:VIII
-
A and B
-
B and C
Pregunta 38
Pregunta
A decreased concentration of fibrinogen leads to bleeding disorders.
Respuesta
- True
- False
Pregunta 39
Pregunta
A congenital deficiency in fibrinogen will result in:
Respuesta
-
Prolonged PT
-
Normal aPTT
-
Normal TT
-
Prolonged aPTT
-
Prolonged TT
Pregunta 40
Pregunta
Which of the Hemophilia conditions is most rare?
Respuesta
-
Hemophilia A (FVIII Deficiency)
-
Hemophilia B (FIX Deficiency)
-
Hemophilia C (FXI Deficiency)
Pregunta 41
Pregunta
Which of the following is not a coagulation regulator?
Respuesta
-
Protein C
-
Thrombin
-
TFPI
-
Plasmin
Pregunta 42
Pregunta
Which of the following regarding Protein C and Protein S is incorrect?
Respuesta
-
activated by thrombin generation by binging to thrombomodulin on endothelial cells
-
inactivates activated V and VIII
-
main regulatory system
-
plasminogen converted Protein C to APC
Pregunta 43
Pregunta
Tissue factor pathway inhibitor only affects the extrinsic pathway.
Respuesta
- True
- False
Pregunta 44
Pregunta
What cofactor does Antithrombin III (AT) need to effectively inhibit IXa, Xa, IIa, and XIa?
Respuesta
-
Warfarin
-
Ca2+
-
Heparin
-
Plasmin
-
vWF
Pregunta 45
Pregunta
Why is fibrinogen important?
Respuesta
-
Prevent thrombi from getting too large
-
Aids in wound healing
-
Prevents thrombosis in undesirable places
-
All of the above
-
None of the above
Pregunta 46
Pregunta
Which of the following are components of the fibrinolytic system?
Respuesta
-
alpha-2 antiplasmin
-
Plasminogen activator inhibitor-1 (PAI-1)
-
Tissue Plasminogen Activator
-
Thrombomodulin
-
Plasmin
Pregunta 47
Pregunta
Thrombocytopenia can be a result of:
Respuesta
-
Hypersplenism
-
Post-splenectomy
-
Acute Blood Loss
-
Proliferation of stem cells
Pregunta 48
Pregunta
Thrombosis refers to:
Respuesta
-
Formation of a blood clot following an injury to a blood vessel
-
Formation of a blood clot inside an intact blood vessel, obstructing the flow of blood
-
Formation of a blood clot that is easily solubilized
-
A portion of a larger clot that breaks free
Pregunta 49
Pregunta
Which of the following would cause a clotting disorder?
Respuesta
-
Protein C deficiency
-
vWD
-
Factor Deficiency
-
Hemophilia A or B
Pregunta 50
Pregunta
Where do the majority of pulmonary emboli originate from?
Respuesta
-
thrombi in arm
-
thrombi in abdomen
-
thrombi in deep leg
-
thrombi in kidney
Pregunta 51
Pregunta
Strokes results from the acute blockage of arterial blood flow in which artery?
Respuesta
-
Pulmonary artery
-
Coronary artery
-
Corotid artery
-
Hepatic artery
Pregunta 52
Pregunta
Which of the following will affect platelet adhesion?
Respuesta
-
Gp IIb receptor on platelet
-
Thromboxane A2
-
Fibrinogen
-
Gp Ib receptor on platelet
Pregunta 53
Pregunta
Which of the following regarding Lupus Anticoagulant is true?
Respuesta
-
causes neutralization of phospholipid reagent in vitro
-
miscarriages are common in SLE
-
LA acts as an antibody to platelet
-
women are more commonly affected
-
followup tests include DRVVT
Pregunta 54
Pregunta
Which of the following regarding DIC is false?
Respuesta
-
begins with excessive clotting stimulated by a substance that enters the blood
-
results in both excessive clotting and excessive bleeding
-
fibrin degradation products are generated
-
DIC is not a systemic problem, localized to specific area
-
plasminogen is consumed as it is converted into plasmin
Pregunta 55
Pregunta
Identify the correct lab results for DIC:
Respuesta
-
increased platelets
-
schistocytes
-
PT and aPTT prolonged
-
D-dimer increased
-
Bleeding Time prolonged
-
Fibrinogen increased
Pregunta 56
Pregunta
D-dimer has a negative predicative value for DIC because:
Respuesta
-
D-dimer measures split products formed after formation of fibrin clot, but is not specific for DIC
-
Usually present in chronic conditions
-
high levels of FDPs are specific for DIC
-
none of the above
Pregunta 57
Pregunta
Which of the following tests is normal in a patient with vWD?
Respuesta
-
Bleeding Time
-
aPTT
-
Platelet count
-
PT
Pregunta 58
Pregunta
Congenital deficiencies of which proteins will cause thrombosis?
Respuesta
-
Deficiency of Thrombin
-
Deficiency of factors
-
Deficiency of Coagulation and Fibrinolytic Regulators
-
Deficiency of Vitamin K
Pregunta 59
Pregunta
How is antithrombin deficiency acquired?
Respuesta
-
Liver disease
-
Nephrotic Syndrome
-
DIC
-
Prolonged heparin therapy
-
all of the above
Pregunta 60
Pregunta
Protein C and Protein S are Vitamin K independent.
Respuesta
- True
- False
Pregunta 61
Pregunta
If APC is added, aPTT is prolonged due to inhibition of coagulation.
Respuesta
- True
- False
Pregunta 62
Pregunta
Which is the most common inherited cause of thrombosis?
Respuesta
-
Protein C or Protein S deficiency
-
Factor V Leiden
-
Plasminogen deficiency
-
Antithrombin deficiency
Pregunta 63
Pregunta
Prothrombin nucleotide 20210 is:
Respuesta
-
A deletion in the gene sequence
-
A single adenine to guanine mutation at position 20210
-
A single guanine to adenine mutation at position 20210
-
A nonsense codon in the sequence
Pregunta 64
Pregunta
FXII deficiency can lead to a bleeding disorder.
Respuesta
- True
- False
Pregunta 65
Pregunta
An increase in plasminogen activator inhibitor 1 will result in
Respuesta
-
a bleeding disorder
-
an increase in fibrinolysis
-
a clotting tendency
-
decrease inhibition of tPA
Pregunta 66
Pregunta
In a mixing study, a prolonged aPTT is corrected with FVIII deficient plasma, but not with FIX deficient plasma. What is the deficiency due to?
Respuesta
-
FVIII
-
FIX
-
Heparin therapy
-
Coumadin therapy
Pregunta 67
Pregunta
A short-filled sodium citrate tube will have what effect on coagulation results?
Respuesta
-
Normal
-
Prolonged for both
-
Only affects PT
-
Only affects aPTT
Pregunta 68
Pregunta
Platelet poor plasma is required for which studies?
Respuesta
-
Coagulation studies
-
Aggregation studies
-
Adhesion studies
-
Fibrinogen studies
Pregunta 69
Pregunta
Which factors would be used up in a clotted specimen?
Respuesta
-
FI
-
FII
-
FV
-
FVII
-
FVIII
-
FXI
-
FXIII
Pregunta 70
Pregunta
Plasma adsorbed with barium sulphate will remove which group of factors?
Respuesta
-
Fibrinogen group factors (I, V, VIII, XIII)
-
Vitamin K dependent factors (II, VII, IX, X)
-
Contact Group Factor (XII, Pre-K, HMWK)
-
TF complex (VII, TF)
Pregunta 71
Pregunta
What is needed to initiate the intrinsic pathway in vitro?
Respuesta
-
Kaolin
-
Tissue factor
-
Phospholipid
-
Calcium
-
Thromboplastin
Pregunta 72
Pregunta
INR is used to monitor heparin therapy.
Respuesta
- True
- False
Pregunta 73
Pregunta
Select all that are true for aPTT:
Respuesta
-
monitors Coumadin therapy
-
screens for defects in the intrinsic and common pathways
-
requires a source of phospholipid
-
required to calculate INR
-
Kaolin is an example of a negatively charged surface needed to activate cascade
Pregunta 74
Pregunta
A mixing studies was performed on a sample and was corrected. To determine if the correction was a result of a factor deficiency or factor antibody, another mixing studies was performed and incubated. The mixing studies results were corrected. This suggests the presence of a factor antibody. Is this interpretation correct?
Respuesta
- True
- False
Pregunta 75
Pregunta
The euglobulin lysis time tests how long it takes for the sample to clot.
Respuesta
- True
- False
Pregunta 76
Pregunta
Which of the following can prolong thrombin time, which looks at how long it takes a sample to clot.
Respuesta
-
Warfarin
-
Heparin
-
FDPs
-
Tissue factor
Pregunta 77
Pregunta
Clot formation time is proportional to the concentration of fibrinogen in the sample plasma.
Respuesta
- True
- False
Pregunta 78
Pregunta
The Clauss method of fibrinogen assay involves
Respuesta
-
extended incubation time
-
using an undiluted plasma sample
-
excess thrombin
-
fibrinogen neutralized by protamine sulphate
Pregunta 79
Pregunta
5M Urea Test involves removing a clot and placing it in 5M urea and incubating it. Which of the following result interpretations are valid?
Respuesta
-
If FII levels are normal, the clot will not dissolve in 24 hours
-
If FXIII is deficient, the clot will not dissolves in 24 hours.
-
If FXIII is normal, the clot will dissolve in 24 hours.
-
If FXIII is deficient, the clot will dissolve in 24 hours.
Pregunta 80
Pregunta
Low Molecular Weight Heparin (LMWH) monitors
Respuesta
-
FVa
-
FVIIa
-
FXa
-
FXIa
Pregunta 81
Pregunta
In a plasma sample with APCr, we expect that
Respuesta
-
Protein C is able to inactive FVa and FVIIIa
-
AT is able to inactivate FVa and FVIIIa
-
Protein C is unable to inactive FVa and FVIIIa
-
AT is unable to inactive FVa and FVIIIa
Pregunta 82
Pregunta
Reptilase time
Respuesta
-
tests for FXIII deficiency
-
compares fibrinogen deficiency and heparin contamination
-
tests for factor antibody (eg. LA)
-
is inhibited by antithrombin
Pregunta 83
Pregunta
Select all that apply to the DRVVT for LA:
Respuesta
-
venom is a potent activator for FX
-
LA binds to phospholipid, inhibiting RVV
-
RVV is affected by deficiency in factors XII, XI, IX, or VIII
-
LA confirmed if DRVVT is corrected in excess phospholipid
Pregunta 84
Pregunta
PT 20s, aPTT 50s, TT 25s
What is the most probably diagnosis?
Respuesta
-
FVII Deficiency
-
FVIII Deficiency
-
FX Deficiency
-
Hypofibrinogenemia
Pregunta 85
Pregunta
Which coagulation test(s) would be abnormal in a vitamin K-dependent patient?
Respuesta
-
PT only
-
aPTT only
-
Both PT and aPTT
-
Fibrinogen level
-
Thrombin time
Pregunta 86
Pregunta
Which of the following is an anticoagulant therapy treatment options?
Respuesta
-
Dabigatran
-
Heparin
-
Anti-platelet (ASA)
-
Warfarin
-
All of the above
Pregunta 87
Pregunta
How does Warfarin (Coumadin) act as a Vitamin K antagonist?
Respuesta
-
Inactivates compound
-
Suppresses reductase activity
-
Competitively binds to Vitamin K
-
None of the above
Pregunta 88
Pregunta
Which factor monitored by Warfarin therapy has the shortest half-life?
Respuesta
-
II
-
VII
-
IX
-
X
-
Protein C
Pregunta 89
Pregunta
If INR low, patient is at risk of bleeding.
Respuesta
- True
- False
Pregunta 90
Pregunta
Which of the following can reduce the effect of Warfarin therapy?
Respuesta
-
Drugs that interfere with Warfarin
-
Increased Vitamin K in diet
-
Taking Warfarin pill at different times every day (not at the same time each day)
-
All of the above
Pregunta 91
Pregunta
Which of the following anti-clotting substances acts on factors V and VIII?
Respuesta
-
Antithrombin III
-
Protein C
-
TFPI
-
Plasmin
-
tPA
Pregunta 92
Pregunta
Which of the following is a cofactor?
Respuesta
-
XII
-
X
-
VIII
-
VII
-
II
Pregunta 93
Pregunta
Heparin activates antithrombin to neutralize serine proteases activated by thrombin.
Respuesta
- True
- False
Pregunta 94
Pregunta
How is Unfractionated Heparin administered?
Respuesta
-
Subcutaneously
-
Intravenously
-
Superficially
-
Orally
Pregunta 95
Pregunta
How is a heparin overdose treated?
Respuesta
-
Warfarin
-
Vitamin K
-
Dialysis
-
Protamine sulfate
Pregunta 96
Pregunta
What side affect may arise as a result of long-term Heparin use?
Respuesta
-
Dyspnea
-
Photophobia
-
Osteoporosis
-
Hypotension
Pregunta 97
Pregunta
Low Molecular Weight Heparin (LMWH) has minimal affect on FIIa activity because it is too short to properly bind IIa.
Respuesta
- True
- False
Pregunta 98
Pregunta
Fondaparinux is a
Respuesta
-
natural drug - pentasaccharide
-
inactivates thrombin by combining with antithrombin
-
intravenous administration
-
requires lab monitoring
Pregunta 99
Pregunta
Which of the following are requires for coagulation in aPTT?
Respuesta
-
Plasma + phospholipid + calcium
-
Plasma + thromboplastin + calcium
-
Plasma + phospholipid + thromboplastin
-
Plasma + thrombin + calcium
Pregunta 100
Pregunta
What is the most common inherited bleeding disorder?
Respuesta
-
TTP
-
Hemophilia A
-
vWD
-
Factor V Leiden
Pregunta 101
Pregunta
Heparin Induced Thrombocytopenia:
Respuesta
-
IgG binds to heparin/PF4 complex
-
leads to coagulation of platelets
-
increases platelet count
-
associated with LMWH
Pregunta 102
Pregunta
Which of the following should be avoided when treating HIT?
Respuesta
-
Streptokinase
-
Urokinase
-
LMWH
-
Hirudin
Pregunta 103
Pregunta
Patients with which of the following diseases may have a normal PTT?
Respuesta
-
vWD
-
Hemophilia A
-
HIT
-
Factor V Leiden
Pregunta 104
Pregunta
Which of the following does not directly inhibit FXa?
Respuesta
-
Apixaban
-
Dabigatran
-
Riveroxaban
-
Edoxaban
Pregunta 105
Pregunta
Which direct thrombin inhibitor is not primarily used to treat HIT?
Respuesta
-
Dabigatran
-
Argatroban
-
Bivalirudin
-
Lepirudin
Pregunta 106
Pregunta
Which of the following are advantages of using Dabigatran?
Respuesta
-
no food interactions (eg. with Vitamin K)
-
no need for routine monitoring
-
reversal of bleeding with charcoal
-
none of the above
-
all of the above
Pregunta 107
Pregunta
Which of the following is false regarding direct FXa inhibitors?
Respuesta
-
requires routine monitoring
-
does not need antithrombin
-
used for the prevention of thrombosis and venous thromboembolism
-
all of the above are true
Pregunta 108
Pregunta
How does Aspirin inhibit platelets from aggregating?
Respuesta
-
Inhibits thrombin
-
Inhibits fibrinogen
-
Inhibits alpha granules
-
Inhibits Thromboxane A2
Pregunta 109
Pregunta
Which condition may thrombolytic therapy be used for?
Respuesta
-
venous thrombosis
-
myocardial infarction
-
Hemophilia A
-
can be administered to any inpatient
Pregunta 110
Pregunta
Which of the following is a "clot buster drug"?
Respuesta
-
Streptokinase
-
tPA
-
Urokinase
-
Thrombin Inhibitors
Pregunta 111
Pregunta
Which of the following is not a thrombolytic therapy?
Respuesta
-
tPA
-
Streptokinase
-
Urokinase
-
Hirudin
-
All of the above are used for thrombolytic therapy
¿Quieres crear tus propios Tests gratis con GoConqr? Más información.