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DF02 Solid State Characters of Drug Powders

Mer Scott 9 preguntas

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Preguntas del test (9)

  1. 1Molecules can arrange themselves in one or more particular ways to form a crystal [blank_start]lattice[blank_end] (3D arrangement of molecules with lots of [blank_start]intermolecular[blank_end] interactions holding the unit cell/crystal together). These different forms are [blank_start]polymorphs[blank_end]. True polymorphs have [blank_start]different[blank_end] 3D arrangements in the crystal lattices and often different [blank_start]melting[blank_end] points; aqueous [blank_start]solubilities[blank_end] & [blank_start]dissolution[blank_end] rates.
    1. Alattice
    2. Bintermolecular
    3. Cpolymorphs
    4. Ddifferent
    5. Emelting
    6. Fsolubilities
    7. Gdissolution
  2. 2Metastable forms are more stable than stable forms, hence moisture or heat can change stable forms into metastable forms.
    1. AVerdadero
    2. BFalso
  3. 3Metastable polymorphs have higher energy than the stable polymorph.
    1. AVerdadero
    2. BFalso
  4. 4A metastable form may have [blank_start]higher[blank_end] solubility ([blank_start]kinetic or metastable[blank_end] solubility) than the most stable form ([blank_start]equilibrium[blank_end] solubility)
    1. Ahigher
    2. Blower
    3. Ckinetic or metastable
    4. Dequilibrium
  5. 5Choose the incorrect statement.
    1. AMetastable forms are less stable than stable forms.
    2. BStable forms are more soluble than metastable forms.
    3. CMetastable forms dissolute faster than stable forms.
  6. 6Sometimes it is possible to make a “saturated” solution using a [blank_start]metastable[blank_end] polymorph, but eventually the [blank_start]stable[blank_end] polymorph may crystallise. The concentration in solution will then will drop to the [blank_start]equilibrium[blank_end] solubility. As a solid [blank_start]crystallises[blank_end] from solution, often it first crystallises as a [blank_start]metastable form[blank_end] which may then change to a more stable form.
    1. Ametastable
    2. Bstable
    3. Cequilibrium
    4. Dcrystallises
    5. Emetastable form
  7. 7A co-crystal is an API with another substance (another [blank_start]API[blank_end] or [blank_start]other substance[blank_end]) often leading to [blank_start]increase[blank_end] in solubility, dissolution rate & [blank_start]bioavailability[blank_end].
    1. AAPI
    2. Bother substance
    3. Cincrease
    4. Dbioavailability
  8. 8[blank_start]Pseudo[blank_end] (false) polymorphs are those drugs which are [blank_start]solvated[blank_end] eg with water, ethanol, acetone, etc. A solvate with water is a [blank_start]hydrate[blank_end].
    1. Asolvated
    2. Bhydrate
    3. CPseudo
  9. 9Choose the incorrect statement.
    1. AProtection from moisture & storage at temperatures
      at usual room temperature or less would be beneficial to prevent changes to a stable form.
    2. BInhibitory polymers could be included in a tablet
      formulation to prevent changes to a stable form.
    3. CAll metastable polymorphs show great tendency to change form.

Información

Descripción
(Formulation) PHCY211 Test sobre DF02 Solid State Characters of Drug Powders, creado por Mer Scott el 28/04/2018.
Idioma
English
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