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Test

MD3 Disintegration as an underlying step of drug release

Mer Scott 12 preguntas

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Preguntas del test (12)

  1. 1Physical changes that take place during tablet compression begin with [blank_start]physical rearrangement[blank_end], which reduces space taken up by particles. Further compression results in deformation; if the particles stay in this shape it is [blank_start]plastic deformation[blank_end] but if they return to their original shape it is [blank_start]elastic deformation[blank_end]. Brittle fracture or [blank_start]fragmentation[blank_end] may also occur. Lastly, [blank_start]interparticulate bonds[blank_end] form in close quarters eg Van der Waals forces, solid bridges, and mechanical interlocking.
    1. Aphysical rearrangement
    2. Bplastic deformation
    3. Celastic deformation
    4. Dfragmentation
    5. Einterparticulate bonds
  2. 2Disintegration is the breaking of interparticulate bonds formed during compression.
    1. AVerdadero
    2. BFalso
  3. 3Which of these is not a widely used disintegrant?
    1. Acrospovidone (XPVP)
    2. Bcroscarmellose sodium (CCS)
    3. Csodium starch glycolate (SSG)
    4. Dcarboxymethyl cellulose (CMC)
  4. 4Choose the incorrect statement.
    1. AIf you add disintegrant before granulation then disintegration of granules will be faster.
    2. BAdding disintegrant before and after granulation creates a slow release tablet.
    3. CIf you add disintegrant after granulation only, disintegration from a tablet to granules will be fast but disintegration of granules will be slow.
  5. 5During disintegration the liquid penetrating the powder builds [blank_start]capillary bridges[blank_end], which cause an [blank_start]attractive force[blank_end] of adjacent particles. A force has to be generated during disintegration which [blank_start]surpasses[blank_end] the interparticulate [blank_start]forces[blank_end] and disrupts the [blank_start]bonds[blank_end].
    The first and often the [blank_start]rate-determining[blank_end] step in disintegration is [blank_start]wicking[blank_end]; the liquid penetration in the [blank_start]porous[blank_end] powder compact. Liquid penetration does [blank_start]not directly build up[blank_end] the pressure which is necessary to rupture the particle-particle bonds, but it is a [blank_start]prerequisite[blank_end] to initiate other mechanisms like swelling.
    1. Acapillary bridges
    2. Battractive force
    3. Csurpasses
    4. Dforces
    5. Ebonds
    6. Frate-determining
    7. Gwicking
    8. Hporous
    9. Inot directly build up
    10. Jprerequisite
  6. 6Disintegration begins with [blank_start]wicking[blank_end], penetration of the porous powder with liquid. Then one or more of: [blank_start]swelling[blank_end] (omni-directional particle enlargement), [blank_start]strain recovery[blank_end] (uni-directional particle enlargement), and [blank_start]dissolution[blank_end] (of particles from pore walls in direct contact with solution) occur. These cause [blank_start]breaking[blank_end] of interparticulate bonds and finally [blank_start]disintegration[blank_end].
    1. Awicking
    2. Bswelling
    3. Cstrain recovery
    4. Ddissolution
    5. Ebreaking
    6. Fdisintegration
  7. 7Swelling builds up [blank_start]pressure[blank_end], [blank_start]pushes apart[blank_end] adjoining particles, and leads to [blank_start]exertion of stresses[blank_end] on the overall system and finally breaks up the tablet.
    The strain within the tablet is the consequence of [blank_start]forcing[blank_end] macromolecules into a [blank_start]metastable[blank_end] configuration either due to interlocking of the polymer chains or as a result of spontaneous [blank_start]crystallisation[blank_end] during the compaction of a tablet. Strain recovery is the undoing of this.
    In addition, the fluid can dissolve or dislodge excipient particles from pore walls, which can significantly affect the [blank_start]porosity[blank_end] and as a result the disintegration performance.
    1. Apressure
    2. Bpushes apart
    3. Cexertion of stresses
    4. Dforcing
    5. Emetastable
    6. Fcrystallisation
    7. Gporosity
  8. 8Mechanistic understanding of pharmaceutical disintegration has a range of significant problems:
    1. All tablets are [blank_start]unique[blank_end] and have a variety of [blank_start]disintegrating matrices[blank_end].
    2. Formulations containing excipients that [blank_start]swell significantly over time[blank_end] with exposure to the dissolution medium, result in strongly [blank_start]non-linear[blank_end] time and temperature dependence of the swelling process.
    3. The [blank_start]process route[blank_end] (direct compaction, dry or wet granulation, compaction conditions) has a significant impact on the tablet [blank_start]microstructure[blank_end].
    4. Excipient [blank_start]physical changes[blank_end] are not as tightly [blank_start]quality controlled[blank_end] as that of APIs.
    1. Aunique
    2. Bdisintegrating matrices
    3. Cswell significantly over time
    4. Dnon-linear
    5. Eprocess route
    6. Fmicrostructure
    7. Gphysical changes
    8. Hquality controlled
  9. 9Dosage forms where disintegration is important for drug release:
    - Most [blank_start]solid dose forms[blank_end] particularly which need to act quickly eg [blank_start]tablets for analgesia[blank_end]
    - [blank_start]Immediate release[blank_end] tablets
    - [blank_start]Orally dispersible[blank_end] tablets, which are designed to disintegrate in the mouth in [blank_start]less than a minutes[blank_end] before swallowing
    1. Asolid dose forms
    2. Btablets for analgesia
    3. CImmediate release
    4. DOrally dispersible
    5. Eless than a minute
  10. 10The [blank_start]disintegration performance[blank_end] has a direct impact on the [blank_start]therapeutic effect[blank_end] of the medication. Without disintegration only the API near the [blank_start]surface[blank_end] of the tablet would be able to dissolve, and would [blank_start]not achieve[blank_end] a reliable clinical performance of the dosage form.
    1. Adisintegration performance
    2. Btherapeutic effect
    3. Csurface
    4. Dnot achieve

Información

Descripción
(Medicines) PHCY211 Test sobre MD3 Disintegration as an underlying step of drug release, creado por Mer Scott el 10/05/2018.
Idioma
English
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