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Test

MD10 Photolysis and Isomerisation + Polymerisation

Mer Scott 13 preguntas

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Preguntas del test (13)

  1. 1Which of these drugs is NOT prone to photolysis?
    1. AHydrocortisone
    2. BPrednisolone
    3. CRiboflavin
    4. DAscorbic acid
    5. EFolic acid
    6. FEscitalopram
  2. 2Choose the incorrect statement about photolysis
    1. AGenerally yields numerous products through complex pathways
    2. BIs often accompanied by oxidation in the presence of oxygen
    3. CCan cause loss of potency of API
    4. DCan occur during storage and handling, but not after administration
  3. 3The primary photochemical reaction is the drug molecule itself [blank_start]absorbing[blank_end] radiation and degrading, ie [blank_start]D → D*[blank_end]. Drug is then in an [blank_start]excited[blank_end] state and must lose the energy.
    Energy can be lost by:
    - Radiative mechanism; [blank_start]D* → D + h.v'[blank_end] (causes fluorescence)
    - Radiationless mechanisms;
    1. Loss of heat, physical decay - [blank_start]D* → D + heat[blank_end]
    2. Quenching, physical decay - [blank_start]D* + D → 2.D[blank_end]
    3. Decomposition, chemical decay - [blank_start]D* → products[blank_end]
    1. AD → D*
    2. Bexcited
    3. Cabsorbing
    4. DD* → D + h.v'
    5. ED* → D + heat
    6. FD* + D → 2.D
    7. GD* → products
  4. 4Colourless drugs absorb wavelengths from the visible spectrum and coloured drugs absorbed from the UV range.
    1. AVerdadero
    2. BFalso
  5. 5Primary photodegradation is when the [blank_start]drug[blank_end] itself absorbs light and degrades. Secondary photodegradation is when an [blank_start]excipient[blank_end] which is photosensitive ([blank_start]photosensitisers[blank_end]) absorbs radiation and then [blank_start]transfers[blank_end] the absorbed energy to the drug, causing it to degrade.
    1. Adrug
    2. Bexcipient
    3. Cphotosensitisers
    4. Dtransfers
  6. 6Which of these functional groups do NOT introduce photo-reactivity? Select all.
    1. AAromatic rings
    2. BB-lactam rings
    3. CAmides
    4. DSulfoxides
    5. ESulfides
    6. FCarboxylic acids
    7. GEsters
    8. HMethyls
    9. IAlcohols
  7. 7Any overlap of the absorption spectrum with solar spectrum has the potential to lead to photochemical change.
    1. AVerdadero
    2. BFalso
  8. 8Which of these is not a factor affecting photolysis?
    1. AFormulation pH
    2. BBuffers in formulation
    3. CTemperature
    4. DExcipients and solvents of formulation
    5. EDrug concentration
    6. FDrug half life
  9. 9The intensity of the transmitted bream through a glass bottle will affect how much light reaches the stored drug. The intensity of the transmitted beam depends on 1) how intense the [blank_start]incident beam[blank_end] is, 2) how much light intensity was [blank_start]absorbed by the glass[blank_end], and 3) how much light was [blank_start]reflected[blank_end] at the two glass-air interfaces. As an equation this is It = [blank_start]Io[blank_end] - ([blank_start]Ia + Ir + Ir[blank_end])
    Ia depends on thickness and absorptivity of the glass. If we increase thickness Ia will [blank_start]increase[blank_end], and the more clear the glass is the [blank_start]smaller[blank_end] Ia is. The minimum glass thickness is [blank_start]2[blank_end] mm.
    1. Aincident beam
    2. Babsorbed by the glass
    3. Creflected
    4. DIo
    5. EIa + Ir + Ir
    6. Fincrease
    7. Gsmaller
    8. H2
    9. I5
  10. 10Amber glass excludes light of wavelength <370 nm.
    1. AVerdadero
    2. BFalso

Información

Descripción
(Medicines) PHCY211 Test sobre MD10 Photolysis and Isomerisation + Polymerisation, creado por Mer Scott el 14/05/2018.
Idioma
English
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7
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