Test
Pharmacokinetics Exam 1
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Preguntas del test (29)
1Which of the following is (are) true?
(Choose all that apply)- AVolume of distribution increases as the amount of drug in the body increases
- BVolume of distribution is inversely proportional to the initial plasma concentration
- CVolume of distribution is constant in a given patient taking a given drug
2Two patients are given the same dose of the same drug. Patient A has an initial concentration of 10 mg/L, but Patient B has an initial concentration of 15 mg/L. Why are the concentrations different?
- APatient A is bigger than Patient B.
- BPatient B is bigger than Patient A.
- CIt is not possible to determine anything about the size of the patient.
3Which pharmacokinetic parameters are most often estimated when dosing a patient empirically?
(Choose all that apply)- Ak
- BVd
- CDose
- DF
4Which of the following would be considered pharmacodynamic monitoring?
(Choose all that apply)- ABlood pressure checks
- BBody temperature
- CBlood glucose levels
5When working with plasma concentration vs. time data for a patient, you are calculating which type of pharmacokinetic parameters?
- APatient-based
- BPopulation-based
- CEmpiric
6What factors affect the absolute availability of a drug administered via the oral route?
(Choose all that apply)- ADose administered
- BFirst pass effect
- CDosage form factors
7Which of the following is true for a drug that is extensively bound to plasma protein?
(Choose all that apply)- AThe drug is easily eliminated by the kidney
- BThe drug is easily metabolized by the liver
- CThe drug has restricted distribution
8In general, a drug with a very large volume of distribution would have
- Aa high initial concentration in the blood.
- Ba low initial concentration in the blood.
- CThere is no relationship between the initial concentration and distribution.
9Which of the following determines the type of pharmacokinetic model to use when dosing a drug?
(Choose all that apply)- ARoute of administration
- BNumber of compartments the drug distributes into
- CNumber of compartments the patient contains
- DDose administered
- EVolume of distribution
10Which term best describes the process the drug undergoes following absorption?
- ADistribution
- BElimination
- CDisposition
- DBiopharmaceutics
- EPharmacokinetics
11If the dose is doubled and the plasma concentration more than doubles, the drug will most likely fit which of the following descriptions?
- ANonlinear pharmacokinetics with dose independent elimination
- BNonlinear pharmacokinetics with dose dependent elimination
- CLinear pharmacokinetics with dose independent elimination
- DLinear pharmacokinetics with dose dependent elimination
12Drugs with a wide therapeutic window also have a __________ therapeutic index.
- ALarge
- BIntermediate
- CSmall
13Which of the following is dose dependent?
(Choose all that apply)- AInitial plasma concentration
- BVolume of distribution
- CHalf life
- DAbsolute availability
14The absolute availability of a brand name drug is 0.8. The generic product of the brand name drug A has relative availability of 1.0. If 100 mg of the generic drug is administered to the patient, how much of the administered dose will reach the systemic circulation?
- A100 mg
- B80 mg
- C20 mg
- DNot enough information to determine
15Assume two different drugs are administered at the same dose to the same patient. The plasma concentration vs. time line is steeper for drug A than for drug B. The y intercept for drug A is 14 mg/L, and the y intercept for drug B is 10 mg/L. The curves are plotted on normal graph paper and appear linear. Which of the following is true?
- APatient A has a faster rate of elimination and a smaller volume of distribution than Patient B.
- BPatient B has a faster rate of elimination and a smaller volume of distribution than Patient A.
- CDrug A has a faster rate of elimination and a smaller volume of distribution than drug B.
- DDrug B has a faster rate of elimination and a smaller volume of distribution than drug A.
16Assume the same drug is administered a the same dose to two different patients. The plasma vs. time curve for Patient A is parallel to that for Patient B. The y-intercept for Patient A is 20 mg/L. The y-intercept for Patient B is 30 mg/L. The curves are plotted on semi-logarithmic graph paper and appear linear. Which of the following is true?
- APatient A has the same rate of elimination and a smaller volume of distribution than Patient B.
- BPatient B has the same rate of elimination and a smaller volume of distribution than Patient A.
- CPatient A has the same half-life and a smaller volume of distribution than Patient B.
- DPatient B has the same half-life and a smaller volume of distribution than Patient A.
17Which of the following is true?
- AIf the dose of the generic dosage form is doubled, the relative availability doubles.
- BDosage form factors can affect both relative and absolute availability.
- CDose affects absolute availability.
- DAbsolute availability for oral dosage forms is: F < 1.
- EThe area under the curve is directly related to dose.
18For an IV bolus one-compartment open model with first order elimination, which of the following is true?
- ADistribution does not occur.
- BThe maximum concentration in each tissue is attained at t = 0.
- CA plot of Cp vs. t is a straight line on regular (Cartersian coordinate) graph paper.
- DThe rate of elimination is constant.
19If a drug has zero order elimination, which of the following is true?
(Choose all that apply)- AThe zero order rate constant is the rate of elimination.
- BThe amount of drug eliminated over the preceding hour is constant.
- CHalf life decreases as the amount of drug remaining decreases.
20A patient is taking 200 mg of a drug every twelve hours for a year. How much drug is eliminated every twelve hours?
- A200 mg
- B400 mg
- C600 mg
- D800 mg
21When the IV bolus dose of a drug is doubled, which of the following occurs?
- AAUC doubles
Vd doubles
Cp0 doubles - BAUC stays the same
Vd doubles
Cp0 doubles - CAUC doubles
Vd stays the same
Cp0 doubles - DAUC doubles
Vd doubles
Cp0 stays the same - EAUC stays the same
Vd stays the same
Cp0 doubles
- AAUC doubles
22If the fraction of drug bound to plasma proteins decreases slightly, what happens to the total plasma concentration measured in the blood?
- APlasma concentration increases slightly.
- BPlasma concentration decreases slightly.
- CPlasma concentration stays the same.
23When calculating a patient's IV bolus dose for the first time, what pharmacokinetic parameter(s) must be estimated?
(Choose all that apply)- Ak
- BV
- CF
24If a drug has an empiric volume of distribution of 60 L, what would the estimated volume of distribution be for a 55 kg patient?
- A47.14 L
- B3300 L
- C1.17 L
- D0.86 L
25If a drug has an extensive apparent volume of distribution, what can be said about the drug?
(Choose all that apply)- AThe drug is located primarily in the tissues.
- BThe drug is primarily plasma protein bound.
- CThe drug is located primarily in the plasma.
26In order to calculate the concentration at any given time following IV bolus administration, you must know which of the following?
(Choose all that apply)- Ak
- BVd
- CDose
27A new drug is given in a single IV bolus dose of 5 mg/kg to adult male patients with an average weight of 80 kg. The equation of the curve that best fits the data is: Cp = 20 mg/L x e^(-.24 hr-1 x t)
What is the volume of distribution for this new drug?- A0.25 L
- B4 L
- C20 L
- D15 L
28A new drug is given in a single IV bolus dose of 5 mg/kg to adult male patients with an average weight of 80 kg. The equation of the curve that best fits the data is: Cp = 20 mg/L x e^(-.24 hr-1 x t)
What is the half life for this new drug?- A5.78 hr
- B2.89 hr
- C1.39 hr
- D0.35 hr
29If a drug has a large volume of distribution, you would expect it to have a relatively ________ half-life.
- AShort
- BLong
- CThere is no relationship between half life and volume of distribution.
Información
- Descripción
- Test sobre Pharmacokinetics Exam 1, creado por Rachel Garrity el 05/12/2014.
- Autor
- Rachel Garrity
- Idioma
- English
- Visitas
- 24
- Valoración
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