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Oncology

James Sante Pharmacy NAPLEX Inglés 45 fichas

Fichas del conjunto (45)

  1. 1ANC Formula[ ( % segs + % bands ) / 100 ] x WBC
  2. 2BSA FormulaSq Rt of [ ( kg x cm ) / 3600 ]
  3. 3Inches (in) --> Centimeters (cm)in x 2.54 = cm
  4. 4Pounds (lb) --> Kilograms (kg)lb / 2.2 = kg
  5. 5Drugs associated w/ pneumonitis & pulmonary fibrosisBleomycin; Busulfan; Methotrexate
  6. 6Brand of busulfanBusulfex
  7. 7Brand of methotrexateTrexall; Rheumatrex
  8. 8Brand of bleomycinBlenoxane
  9. 9Generic of Platinol-AQcisplatin
  10. 10Generic of Adriamycindoxorubicin
  11. 11CardiomyopathiesDoxorubicin (Adriamycin)
  12. 122 "types" of dexrazoxaneZinecard = Prophylaxis of doxorubicin-induced cardiomyopathy; Totect = Treatment of anthracycline extravasation
  13. 13Cell Cycle Specific AgentsVincas; Taxanes; Topo-Inhibitors; Pyrimidines; Folate Antimetabolites
  14. 14Vinca Alkaloids ("Vincas")Vinblastine; Vincristine; Vinorelbine
  15. 15VincristineTop3 TidBits = (1) 2 mg/dose cap; (2) Constipation; (3) Use WARM compresses [not cold] if extravasation
  16. 16VinblastineTop2 TidBits = (1) Myelosuppressive [as well as vinorelbine]; (2) Use WARM compresses
  17. 17TaxanesDocetaxel; Paclitaxel
  18. 18Docetaxel = TaxotereTop3 TidBits = (1) Severe fluid retention; (2) Infusion-related HSR; (3) Peripheral sensory neuropathies
  19. 19Paclitaxel = TaxolTop2 TidBits = (1) Premedicate w/ diphenhydramine, corticosteroid, H2RA; (2) Albumin-bound version "Abraxane" needs no premedication [i.e. low allergic reaction]
  20. 20Topoisomerase I Inhibitors (Topo1-Inhibitors)Irinotecan; Topotecan
  21. 21Irinotecan = CamptosarTop4 TidBits = (1) N/V/*D*; (2) Homozygous for UGT1A1*28 at inc. risk for neutropenia, delayed diarrhea; (3) Use only when ANC > 1,500; (4) Myelosuppression
  22. 22Topotecan = HycamtinTop2 TidBits = (1) Use only when ANC > 1,500 and PLT > 100,000; (2) Myelosuppression
  23. 23Topoisomerase II Inhibitors (Topo2-Inhibitors)Etoposide CAPSULES; Etoposide IV; Etoposide Phosphate
  24. 24Etoposide CAPSULES = VePesidRequire refrigeration (RARE!); Divide doses > 200 mg; Myelo; HSR
  25. 25Etoposide IV = ToposarRate-related hypotension (i.e. infuse over 30-60 minutes); Non-PVC bag/tubing due to DEHP leaching
  26. 26Pyrimidine Analog Antimetabolites ("Pyrimidines")Fluorouracil ("5-FU"); Capecitabine; Cytarabine; Gemcitabine
  27. 27Fluorouracil (5-FU) = AdrucilTop3 TidBits = (1) Given w/ LEUCOVORIN to inc. EFFICACY (think *booster*); (2) DPD deficiency inc. risk of severe toxicity; (3) "Efudex" brand also used for BCC
  28. 28Capecitabine = XelodaTop3 TidBits = (1) C/I in CrCL < 30 mL/min); (2) PO prodrug of 5-FU; (3) ***HAND-FOOT SYNDROME***
  29. 29Cytarabine = "ara-C""Cytarabine Syndrome" (fever, flu-like, myalgia, bone pain, rash); Pulmonary toxicity; ***HAND-FOOT SYNDROME***
  30. 30Folate AntimetabolitesMethotrexate (MTX); Pemetrexed
  31. 31MTX = Trexall; Rasuvo; etc."High-Dose MTX" (> 500 mg/m^2) requires LEUCOVORIN "rescue"; *HYDRATION* & *NaHCO3* to dec. nephrotoxicity risk; Glucarpidase (Voraxaze) is the expensive rescue agent
  32. 32METHOTREXATE DOSINGCancer Dosing is MUCH HIGHER than Rheumatoid Arthritis or Psoriasis Dosing --> Daily v. Weekly (respectively)
  33. 33Pemetrexed = AlimtaGive folic acid, vit. B12, dexamethasone to dec. risk of side effects
  34. 34INTRATHECAL administration of MTX...Use ONLY the ***Preservative-Free*** formulation!!!
  35. 35M Phase Agents --> (These inhibit microtubule function...)Vincas (vinblastine, vincristine); Taxanes (docetaxel, paclitaxel)
  36. 36S Phase AgentsTopo1-Inhibitors (irinotecan, topotecan); Pyrimidines (5-FU, capecitabine, cytarabine, gemcitabine); Folate Antimetabolites (MTX, pemetrexed)
  37. 37G2 Phase Agents --> (There is only one...)Topo2-Inhibitors (etoposide)
  38. 38Any phase-specific cancer drug that can cause pulmonary complications (e.g. pneumonitis, fibrosis, toxicity, etc.)Bleomycin; Busulfan; MTX; Cytarabine (*toxicity*)
  39. 39Phase-specific cancer drugs in which a "dose cap" or "pre-requisite" should be associatedVincristine (2 mg/dose cap); Irinotecan = Camptosar (ANC must > 1,500); Topotecan = Hycamtin (ANC must > 1,500; PLT must > 100,000); Capecitabine = Xeloda (C/I in CrCL < 30); MTX (>500 mg dose BSA req. Leucovovrin and/or Glucarpidase = Voraxaze)
  40. 40"Rare capsules" that require refrigerationEtoposide = VePesid
  41. 41Biggest culprit of hand-foot syndromeCapecitabine = Xeloda; Cytarabine = "ara-C"
  42. 42LEUCOVORIN pairings...If leuco is given w/ 5-FU = ***BOOSTER***
    If leuco is given w/ MTX = ***RESCUER***
  43. 43Which of the Taxanes typically requires pre-medication?Paclitaxel = Taxol
    [However, albumin-bound Abraxane needs no pre-medication!]
  44. 44The AE profile of Platinol-AQ (cisplatin)...N/*V*/D; Dose-limiting nephrotoxicity; Ototoxicity (e.g. tinnitus); Neurotoxicity
  45. 45Maximum Lifetime Dose of Adriamycin (doxorubicin)?550 mg dose BSA

Información

Descripción
A review flashcard set of all things ONCOLOGY (e.g. side effect management, common cancer types, treatment, etc.)
Creado por
James Sante
Visitas
22
Etiquetas
oncology
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