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T2DM - HPA
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- 1What is T2DMA condition in which the body slowly becomes resistant to insulin and/or slowly loses the capacity to produce enough insulin to meet BGL demand
- 2What are the risk factors?- Increasing age
- Obesity/increased amount of abdominal fat
- Physical inactivity
- Hypertension
- High cholesterol and/or triglyceride level
- Occurs more frequently in women that have a history of gestational diabetes, polycystic ovary syndrome or delivering a baby weighing more than 4.1kg
- Strong genetic predisposition - 3CausesNot well known, links to obesity are strong but research is not clear on the exact cause of the pathophys of the disease
- 4PathophysiologyProgressive condition in which the body becomes resistant to the normal effects of insulin and/or gradually loses the capacity to produce enough insulin in the pancreas. Type II DM is a condition of fasting hyperglycaemia despite the availability of endogenous insulin.
Insulin resistance forces the pancreas to work harder and produce more insulin, but when demand exceeds supply, DM results. There is insufficient insulin to prevent the breakdown of fats with resultant ketosis. Therefore Type II is a nonketotic form of diabetes. - 5Symptoms2 Ps - polydipsia and polyuria
Blurred vision, fatigue, paraesthesia, skin infections - all the result of hyperglycaemia. - 6Medications & treatmentPeople with type II are usually able to control glucose levels with diet and/or an oral hypoglycaemic medication.
If control is inadequate, insulin may be required. Insulin (such as Actrapid) is introduced when beta-cell function declines
Oral hypoglycaemic meds: - Gliclazide & Metformin
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- El usuario ha eliminado su información de asignaturas Fichas sobre T2DM - HPA, creado por Usuario eliminado el 10/06/2018.
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- Creado por Em J · 9 jun 2018
- Copiado por Em J · 10 jun 2018
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