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HPA - metronidazole
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- 1What is it?A nitromidazole antibiotic
- 2IndicationsGram-positive and Gram-negative anaerobic bacterial infections, eg B. fragilis
Protozoal infections, eg giardiasis, trichomoniasis - 3ActionMetronidazole and tinidazole are metabolised to active metabolites that are thought to interfere with DNA synthesis.
- 4Therapeutic effectsKills bacteria by interfering with synthesis of its DNA - reducing infection and therefore inflammation
- 5AbsorptionAbsorbed well in the GIT - 70 - 90% bioavailability
- 6Metabolism and excretionMetabolised (>70% ) in the liver and excreted through the kidneys
- 7DistributionExcept placenta, metronidazole penetrates well into body tissues and fluids
- 8Half-life6 -8 hours
- 9ContraindicationsContraindicated in individuals hypersensitive to drug or its components (such as parabens) or other nitromidazole derivatives
Use cautiously in individuals with history or evidence of blood dyscrasia and in those with severe hepatic disease - 10Side effectsabdominal pain, n + v, diarrhoea, metallic taste, CNS effects: dizziness, headache
Alcohol interaction: similar to disulfram can cause nausea vomiting, tachycardia SOB and flushing (avoid taking with alcohol) - 11InteractionsAlcohol - avoid use
- 12Nursing assessmentMonitor for adverse affects
BP - 13EducationTake metronidazole tablets with food to reduce stomach upset.
This medicine may make you feel dizzy or confused; avoid driving if you are affected like this.
Avoid alcohol!
Stop taking metronidazole and check with your doctor immediately if you have any numbness, tingling, pain or weakness in hands or feet.
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- El usuario ha eliminado su información de asignaturas Fichas sobre HPA - metronidazole, creado por Usuario eliminado el 10/06/2018.
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- Creado por Em J · 10 jun 2018
- Copiado por Em J · 10 jun 2018
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