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Daptomycin

Zainab Hassoun Pharmacy idk man Inglés 12 fichas

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1Daptomycin is effective against ______________Staphylococci (like MRSA, MSSA)
Streptococci (like Strep A, D, and Strep viridans)
Anaerobes!
2T/F: Daptomycin's antimicrobial spectrum extends to aerobic and anaerobic gram positive bacteria.True
3What do we use Daptomycin for?hospital acquired pneumonia :///
complicated skin infections
4Is daptomycin time-dependent or concentration dependent?Concentration Dependent!
5What does daptomycin depend on?Activity of daptomycin is affected by the CONCENTRATION of Ca 2+
6ok so how does daptomycin kill bacteria1. it's inserted into the lipid bilayer
2. it aggregates in the cell membrane
3. depolarizes that baby with its potassium efflux (this results in a loss of membrane potential --> inhibition of protein, DNA, & RNA --> nonfunctional cell)
4. cell dead
7Side effects of daptomycininjection site pain, irritation, inflammation
headache, insomnia, fever, rash
nausea, vomiting, diarrhea
8daptomycin + HMG-CoA reductase inhibitors = ???????increased risk for myopathy (muscle weakness)
9T/F: dosage modification is NOT necessary for hemodialysis patientsFALSE
10What effect on clearance does daptomycin have in obese patients?clearance is DECREASED
111. PAE of daptomycin? 2. t 1/2 of daptomycin?1. prolonged PAE = 5-10 hrs
2. t 1/2 = 8-9 hrs
12where does daptomycin primarily get excreted into?URINE