Celiac Disease

Celiac Disease

1. It affects

   • small intestine
     • Anatomy of the small intestine
     • Histology

2. Pathophysiology

3. Associated Conditions

   • Type 1 diabetes mellitus
   • Autoimmune hepatitis
   • Sjögren’s syndrome
   • Multiple Sclerosis
   • Addison disease
   • Arthritis

4. Complications

   • Osteoporosis
   • Lactose intolerance
   • Lymphoma and small bowel cancer
   • Infertility
   • Iron deficiency anemia
     • Causes
       • Blood loss
       • lack of iron in your diet
       • inability to absorb iron
       • Pregnancy
   • steatorrhea
     • Causes
       • cystic fibrosis
       • chronic pancreatitis
       • lactose intolerance
       • Whipple disease

5. The differences with IBS

6. Sign & symptoms

   • Diarrhea
   • Bloating
     • Fatigue
       • Abdominal discomfort
         • weight loss
           • Joint pain
             • GERD and heartburn

7. Part of

   • Malabsorption syndromes
     • Intraluminal
       • Pancreatic insufficiency
       • Bile acid/salt deficiency
     • Brush border
       • Infective enterocolitis
     • Lymphatic transport
       • whipple’s disease
     • It affects
       • GI system
         • Physical examination
           • Introduction
           • Inspection
             • Clubbing, leukunychia
             • Palmar erythema, Duputyren's contracture
             • spider navi, gynecomastia
             • Ascites, campus medusa
           • Palpation & percussion
           • Auscultatoin
           • Rectal Examination

8. Screening

   • Anti – tissue Transglutaminase Antibody
   • (IgA) test
   • anti-DGP
   • Anti-endomysial antibodies
   • Anti-reticulin antibody

9. Investigations

   • Endoscopy
   • Biopsy
   • CBC  anemia
   • Stool fat
   • CT

10. Treatment

    • Lifelong Adherence to the Gluten-Free Diet
      • Avoid
        • Wheat
        • Barley
        • Rye
    • Vitamins and Dietary Supplements
      • , iron, calcium, magnesium, zinc,
      • folate, niacin, riboflavin, vitamin B12, and vitamin D

11. Role of registered dietition

    • Assess nutritional status
    • Counsel
    • Assess Psychosocial status
    • Adress comorbidities

12. Prognosis

    • untreated or unresponsive celiac disease have increased early mortality

13. Epidemiology

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